Continuation of the Chronic Renal Insufficiency Cohort (CRIC)

慢性肾功能不全队列 (CRIC) 的延续

• 批准号: 10730902
• 负责人: Amanda Hyre Anderson
• 金额: $ 100万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-28 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10730902
• 关键词: Adult; Affect; Ancillary Study; Arrhythmia; Biological; Biometry; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Chronic Kidney Failure; Chronic Kidney Insufficiency; Chronic Phase; Clinical; Clinical Trials; Cohort Studies; Communities; Complex; Data; Data Collection; Data Coordinating Center; Data Sources; Development; Disease Progression; Eligibility Determination; Enrollment; Ensure; Epidemiology; Evaluation; Event; Evolution; Funding; Future; Goals; Heterogeneity; Home; Individual; Infrastructure; Institution; Intervention; Investigation; Kidney Diseases; Kidney Failure; Leadership; Link; Measurement; Measures; Medical; National Institute of Diabetes and Digestive and Kidney Diseases; Observational Study; Observational epidemiology; Outcome; Output; Participant; Pathway interactions; Patient Care; Patient-Focused Outcomes; Pennsylvania; Persons; Phase; Phenotype; Physiological; Process; Productivity; Prospective Studies; Prospective cohort; Protocols documentation; Renal function; Research; Research Personnel; Resources; Risk Factors; Sampling; Source; Translational Research; United States; Universities; Visit; adjudication; adverse outcome; clinical center; clinical epidemiology; cohort; comorbidity; data acquisition; data exchange; data integration; design; epidemiology study; ethnic diversity; experience; follow-up; health data; innovation; novel; participant enrollment; phenotypic data; premature; programs; prospective; racial diversity; renal damage; repository; social; tool

PROJECT SUMMARY This application is submitted by the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania to serve as the Scientific and Data Coordinating Center (SDCC) for Phase 5 of the Chronic Renal Insufficiency Cohort (CRIC) Study. Since its inception in 2001, the CRIC Study has enrolled and followed a racially and ethnically diverse cohort of 5,625 individuals with reduced kidney function at 7 Clinical Centers across the United States. As the landmark prospective evaluation of CKD, the CRIC Study has performed extensive and deep biological, physiological, and social phenotyping, and ascertained longitudinal clinical and patient-centered outcomes across multiple domains. Findings from the CRIC Study have defined trajectories of CKD progression, catalogued development and evolution of comorbidities in CKD, and identified a diverse array of factors and pathways that explain the progression and complications of CKD in adults. Through its highly productive Ancillary Studies and Opportunity Pool Programs, both the scientific scope of the CRIC Study and the community of kidney disease researchers have been markedly expanded. During the most recent funding cycle (Phase 4: 2018-2023), three innovative subprotocol studies were implemented to enrich CRIC data with highly granular home-based assessments of kidney function and cardiovascular measures. During the fifth and final phase of the CRIC Study, the major goals will be to (1) ascertain the clinical outcomes for all participants including those enrolled in the Phase 4 subprotocols, (2) perform analyses linking the subprotocol measurements to clinical outcomes, (3) integrate data from multiple domains to identify subphenotypes underlying the heterogeneity in CKD progression outcomes, (4) conduct final study visits for the full CRIC cohort eligible for Phase 5, (5) create mechanisms for future data collection via linkages with external sources of health data, and (6) generate tools and resources to facilitate ongoing use of CRIC data and biospecimens by a broad group of investigators after the CRIC Study has formally ended. An important product of the Phase 5 analytical activities will be a data-driven holistic CKD framework that will depict the complex interplay of contributors to CKD progression and cardiovascular complications, inform patient care, and guide the design of future clinical trials. The SDCC, led by a highly experienced team of investigators from the University of Pennsylvania, Tulane University, and Northwestern University, will provide scientific and operational leadership to ensure that the CRIC Study Group achieves these goals. The proposed activities, coordinated between the Clinical Centers and the SDCC, will generate new scientific output and successfully transition the CRIC Study from its active, prospective cohort phase to a long-lasting resource for supporting ongoing and future mechanistic, epidemiologic, and translational investigations.

项目总结

项目成果

Envelope method with ignorable missing data.

• DOI: 10.1214/21-ejs1881
• 发表时间: 2021-01
• 期刊: Electronic journal of statistics
• 影响因子: 1.1
• 作者: Linquan Ma;Lan Liu;Wei Yang

Efficacy, Safety, and Tolerability of Oral Furosemide Among Patients Receiving Hemodialysis: A Pilot Study.

• DOI: 10.1016/j.ekir.2022.07.003
• 发表时间: 2022-10
• 期刊: KIDNEY INTERNATIONAL REPORTS
• 影响因子: 6
• 作者: Flythe, Jennifer E.;Assimon, Magdalene M.;Tugman, Matthew J.;Narendra, Julia H.;Singh, Simran K.;Jin, Wanting;Li, Quefeng;Bansal, Nisha;Hostetter, Thomas H.;Dember, Laura M.
• 通讯作者: Dember, Laura M.

Dysnatremias, Mortality, and Kidney Failure in CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.

• DOI: 10.1016/j.xkme.2022.100554
• 发表时间: 2022-12
• 期刊: KIDNEY MEDICINE
• 影响因子: 3.9
• 作者: Hassanein, Mohamed;Arrigain, Susana;Schold, Jesse D.;Nakhoul, Georges N.;Navaneethan, Sankar D.;Mehdi, Ali;Sekar, Arjun;Tabbara, Jad;Taliercio, Jonathan J.;CRIC Investigators, C. R. I. C. Investigators
• 通讯作者: CRIC Investigators, C. R. I. C. Investigators

Regional Variation in Hemoglobin Distribution Among Individuals With CKD: the ISN International Network of CKD Cohorts.

• DOI: 10.1016/j.ekir.2023.07.032
• 发表时间: 2023-10
• 期刊: KIDNEY INTERNATIONAL REPORTS
• 影响因子: 6
• 作者: Canney, Mark;Induruwage, Dilshani;Tang, Mila;de Pinho, Natalia Alencar;Er, Lee;Zhao, Yinshan;Djurdjev, Ognjenka;Ahn, Yo Han;Behnisch, Rouven;Calice-Silva, Viviane;Chesnaye, Nicholas C.;de Borst, Martin H.;Dember, Laura M.;Dionne, Janis;Ebert, Natalie;Eder, Susanne;Fenton, Anthony;Fukagawa, Masafumi;Furth, Susan L.;Hoy, Wendy E.;Imaizumi, Takahiro;Jager, Kitty J.;Jha, Vivekanand;Kang, Hee Gyung;Kitiyakara, Chagriya;Mayer, Gert;Oh, Kook-Hwan;Onu, Ugochi;Pecoits-Filho, Roberto;Reichel, Helmut;Richards, Anna;Schaefer, Franz;Schaeffner, Elke;Scheppach, Johannes B.;Sola, Laura;Ulasi, Ifeoma;Wang, Jinwei;Yadav, Ashok K.;Zhang, Jianzhen;Feldman, Harold, I;Taal, Maarten W.;Stengel, Benedicte;Levin, Adeera
• 通讯作者: Levin, Adeera

Dynamic Remodeling of Human Arteriovenous Fistula Wall Obtained From Magnetic Resonance Imaging During the First 6 Months After Creation.

• DOI: 10.1016/j.ekir.2022.05.016
• 发表时间: 2022-08
• 期刊: KIDNEY INTERNATIONAL REPORTS
• 影响因子: 6
• 作者: Li, Yingnan;He, Yong;Falzon, Isabelle;Fairbourn, Brayden;Tingey, Spencer;Imrey, Peter B.;Radeva, Milena K.;Beck, Gerald J.;Gassman, Jennifer J.;Roy-Chaudhury, Prabir;Berceli, Scott A.;Cheung, Alfred K.;Shiu, Yan-Ting
• 通讯作者: Shiu, Yan-Ting