Continuation of the Chronic Renal Insufficiency Cohort (CRIC)

慢性肾功能不全队列 (CRIC) 的延续

• 批准号: 10730902
• 负责人: Amanda Hyre Anderson
• 金额: $ 100万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-28 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10730902
• 关键词: Adult; Affect; Ancillary Study; Arrhythmia; Biological; Biometry; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Chronic Kidney Failure; Chronic Kidney Insufficiency; Chronic Phase; Clinical; Clinical Trials; Cohort Studies; Communities; Complex; Data; Data Collection; Data Coordinating Center; Data Sources; Development; Disease Progression; Eligibility Determination; Enrollment; Ensure; Epidemiology; Evaluation; Event; Evolution; Funding; Future; Goals; Heterogeneity; Home; Individual; Infrastructure; Institution; Intervention; Investigation; Kidney Diseases; Kidney Failure; Leadership; Link; Measurement; Measures; Medical; National Institute of Diabetes and Digestive and Kidney Diseases; Observational Study; Observational epidemiology; Outcome; Output; Participant; Pathway interactions; Patient Care; Patient-Focused Outcomes; Pennsylvania; Persons; Phase; Phenotype; Physiological; Process; Productivity; Prospective Studies; Prospective cohort; Protocols documentation; Renal function; Research; Research Personnel; Resources; Risk Factors; Sampling; Source; Translational Research; United States; Universities; Visit; adjudication; adverse outcome; clinical center; clinical epidemiology; cohort; comorbidity; data acquisition; data exchange; data integration; design; epidemiology study; ethnic diversity; experience; follow-up; health data; innovation; novel; participant enrollment; phenotypic data; premature; programs; prospective; racial diversity; renal damage; repository; social; tool

PROJECT SUMMARY This application is submitted by the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania to serve as the Scientific and Data Coordinating Center (SDCC) for Phase 5 of the Chronic Renal Insufficiency Cohort (CRIC) Study. Since its inception in 2001, the CRIC Study has enrolled and followed a racially and ethnically diverse cohort of 5,625 individuals with reduced kidney function at 7 Clinical Centers across the United States. As the landmark prospective evaluation of CKD, the CRIC Study has performed extensive and deep biological, physiological, and social phenotyping, and ascertained longitudinal clinical and patient-centered outcomes across multiple domains. Findings from the CRIC Study have defined trajectories of CKD progression, catalogued development and evolution of comorbidities in CKD, and identified a diverse array of factors and pathways that explain the progression and complications of CKD in adults. Through its highly productive Ancillary Studies and Opportunity Pool Programs, both the scientific scope of the CRIC Study and the community of kidney disease researchers have been markedly expanded. During the most recent funding cycle (Phase 4: 2018-2023), three innovative subprotocol studies were implemented to enrich CRIC data with highly granular home-based assessments of kidney function and cardiovascular measures. During the fifth and final phase of the CRIC Study, the major goals will be to (1) ascertain the clinical outcomes for all participants including those enrolled in the Phase 4 subprotocols, (2) perform analyses linking the subprotocol measurements to clinical outcomes, (3) integrate data from multiple domains to identify subphenotypes underlying the heterogeneity in CKD progression outcomes, (4) conduct final study visits for the full CRIC cohort eligible for Phase 5, (5) create mechanisms for future data collection via linkages with external sources of health data, and (6) generate tools and resources to facilitate ongoing use of CRIC data and biospecimens by a broad group of investigators after the CRIC Study has formally ended. An important product of the Phase 5 analytical activities will be a data-driven holistic CKD framework that will depict the complex interplay of contributors to CKD progression and cardiovascular complications, inform patient care, and guide the design of future clinical trials. The SDCC, led by a highly experienced team of investigators from the University of Pennsylvania, Tulane University, and Northwestern University, will provide scientific and operational leadership to ensure that the CRIC Study Group achieves these goals. The proposed activities, coordinated between the Clinical Centers and the SDCC, will generate new scientific output and successfully transition the CRIC Study from its active, prospective cohort phase to a long-lasting resource for supporting ongoing and future mechanistic, epidemiologic, and translational investigations.

项目摘要 该申请由大学临床流行病学和生物统计学中心提交 宾夕法尼亚州作为慢性的第5阶段的科学和数据协调中心（SDCC） 肾功能不全队列（CRIC）研究。自2001年成立以来，CRIC研究已经招收， 跟随5,625名肾功能降低的种族和种族多样性的队列，在7个临床上 在美国的中心。作为对CKD的具有里程碑意义的预期评估，CRIC研究已有 进行了广泛而深层的生物学，生理和社会表型，并确定了纵向 跨多个领域的临床和以患者为中心的结果。 CRIC研究的发现定义了 CKD进展的轨迹，CKD合并症的开发和进化的轨迹，并确定 各种因素和途径解释了成人CKD的进展和并发症。 通过其高生产力的辅助研究和机会池计划，既是科学范围 CRIC研究和肾脏疾病研究人员的社区已显着扩大。在 最近的最新资助周期（第4阶段：2018-2023），实施了三项创新的子协议研究 富含肾功能和心血管的基于颗粒状家庭的评估的浓缩cric数据 措施。在CRIC研究的第五阶段也是最后一个阶段中，主要目标是（1）确定 所有参与者的临床结果，包括参加第4阶段子协议的参与者，（2）进行分析 将子协议测量与临床结果联系起来，（3）整合来自多个领域的数据以识别 CKD进展结果中异质性的基础型亚表格，（4）进行最终研究访问 完整的CRIC队列有资格获得第5阶段的资格，（5）通过与 健康数据的外部来源，以及（6）生成工具和资源，以促进不断使用CRIC数据 在CRIC研究正式结束后，一群研究人员的生物测量。一个重要的 第5阶段分析活动的产品将是数据驱动的整体CKD框架，将描绘 CKD进展和心血管并发症的贡献者的复杂相互作用，告知患者护理， 并指导未来临床试验的设计。 SDCC由经验丰富的调查人员团队的领导 宾夕法尼亚大学，杜兰大学和西北大学将提供科学和 运营领导才能确保CRIC研究小组实现这些目标。提议的活动， 临床中心和SDCC之间的协调将产生新的科学输出，并成功地 过渡CRIC研究从其活跃的前瞻性队列阶段转变为支持的持久资源 正在进行的和未来的机械，流行病学和翻译研究。

项目成果

Envelope method with ignorable missing data.

• DOI: 10.1214/21-ejs1881
• 发表时间: 2021-01
• 期刊: Electronic journal of statistics
• 影响因子: 1.1
• 作者: Linquan Ma;Lan Liu;Wei Yang

Efficacy, Safety, and Tolerability of Oral Furosemide Among Patients Receiving Hemodialysis: A Pilot Study.

• DOI: 10.1016/j.ekir.2022.07.003
• 发表时间: 2022-10
• 期刊: KIDNEY INTERNATIONAL REPORTS
• 影响因子: 6
• 作者: Flythe, Jennifer E.;Assimon, Magdalene M.;Tugman, Matthew J.;Narendra, Julia H.;Singh, Simran K.;Jin, Wanting;Li, Quefeng;Bansal, Nisha;Hostetter, Thomas H.;Dember, Laura M.
• 通讯作者: Dember, Laura M.

Dysnatremias, Mortality, and Kidney Failure in CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.

• DOI: 10.1016/j.xkme.2022.100554
• 发表时间: 2022-12
• 期刊: KIDNEY MEDICINE
• 影响因子: 3.9
• 作者: Hassanein, Mohamed;Arrigain, Susana;Schold, Jesse D.;Nakhoul, Georges N.;Navaneethan, Sankar D.;Mehdi, Ali;Sekar, Arjun;Tabbara, Jad;Taliercio, Jonathan J.;CRIC Investigators, C. R. I. C. Investigators
• 通讯作者: CRIC Investigators, C. R. I. C. Investigators

Regional Variation in Hemoglobin Distribution Among Individuals With CKD: the ISN International Network of CKD Cohorts.

• DOI: 10.1016/j.ekir.2023.07.032
• 发表时间: 2023-10
• 期刊: KIDNEY INTERNATIONAL REPORTS
• 影响因子: 6
• 作者: Canney, Mark;Induruwage, Dilshani;Tang, Mila;de Pinho, Natalia Alencar;Er, Lee;Zhao, Yinshan;Djurdjev, Ognjenka;Ahn, Yo Han;Behnisch, Rouven;Calice-Silva, Viviane;Chesnaye, Nicholas C.;de Borst, Martin H.;Dember, Laura M.;Dionne, Janis;Ebert, Natalie;Eder, Susanne;Fenton, Anthony;Fukagawa, Masafumi;Furth, Susan L.;Hoy, Wendy E.;Imaizumi, Takahiro;Jager, Kitty J.;Jha, Vivekanand;Kang, Hee Gyung;Kitiyakara, Chagriya;Mayer, Gert;Oh, Kook-Hwan;Onu, Ugochi;Pecoits-Filho, Roberto;Reichel, Helmut;Richards, Anna;Schaefer, Franz;Schaeffner, Elke;Scheppach, Johannes B.;Sola, Laura;Ulasi, Ifeoma;Wang, Jinwei;Yadav, Ashok K.;Zhang, Jianzhen;Feldman, Harold, I;Taal, Maarten W.;Stengel, Benedicte;Levin, Adeera
• 通讯作者: Levin, Adeera

Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort.

• DOI: 10.1093/cdn/nzac111
• 发表时间: 2022-08
• 期刊: Current developments in nutrition
• 影响因子: 4.8