Miami-ECHO: A Diverse Cohort of Mothers, Children and Fathers in Miami-Dade County

迈阿密-ECHO：迈阿密-戴德县的母亲、儿童和父亲的多元化群体

• 批准号: 10746614
• 负责人: Michael John Paidas
• 金额: $ 235.49万
• 依托单位: UNIVERSITY OF MIAMI CORAL GABLES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10746614
• 关键词: Address; Affect; African American population; African Caribbean; Age; Area; Asian population; Automobile Driving; Biological; Biological Process; Birth; Caring; Child; Child Development; Child Health; Childhood; Cohort Studies; Communities; Complex; Conceptions; County; Data; Discipline; Discrimination; Disease susceptibility; Disparity; Disparity population; Economics; Elderly; Environmental Risk Factor; Ethnic Origin; Ethnic Population; Family Planning; Fathers; Florida; Funding; Genes; Genome; Goals; Haitian; Health; Hispanic; Home; Individual; Inequity; Infant Health; Infrastructure; Insurance Coverage; Language; Latino Population; Life Experience; Linguistics; Maternal and Child Health; Mediating; Minority; Minority Women; Morbidity - disease rate; Mothers; Not Hispanic or Latino; Outcome; Parents; Perinatal; Persons; Population; Population Distributions; Population Heterogeneity; Poverty; Pregnancy; Pregnant Women; Protocols documentation; Race; Research; Role; Science; Scientific Advances and Accomplishments; Shapes; Social Environment; Social Identification; Social support; Stress; United States National Institutes of Health; Woman; Work; cohort; disorder risk; early childhood; ethnic diversity; ethnic minority; ethnic minority population; experience; global health; health disparity; improved; infant death; member; metropolitan; middle childhood; multi-racial; multidisciplinary; neurodevelopment; offspring; outcome disparities; perinatal period; prenatal; programs; psychologic; racial diversity; racial minority; racial minority population; racial population; racism; recruit; skin color; social; social genomics; social health determinants; social stressor; socioeconomic adversity

PROJECT SUMMARY/ABSTRACT Disparities in maternal-child health increase generationally because stress experienced by mothers can be transferred to their children, with both biological and psychological consequences. Without clear understanding of factors driving these disparate outcomes and without longitudinal assessments across racial and ethnic groups, inequities will persist. The Environmental influences on Child Health Outcomes (ECHO) Program aims to understand the effects of early environmental factors on child health and development, and therefore needs a diverse cohort of children and their parents who represent the variety of U.S. populations, especially racial and ethnic minority populations who often are at the intersection of socioeconomic adversity and social stressors related to race/ethnicity. We propose to establish the Miami-ECHO cohort of racially and ethnically diverse mothers, children, and fathers. We will recruit and retain a racially and ethnically diverse cohort of pregnant women (N=1,250), their offspring, and the conceiving father from Miami-Dade County (MDC), Florida. In addition, we will recruit and retain 60-80% of the cohort mothers into the ECHO preconception pilot protocol. MDC is a minority-majority county with a population of 69.4% Hispanic/Latinos (including Afro-Caribbeans), 17.7% African Americans, 12.9% Non-Hispanic Whites, 3% Asians, and 1.3% multi-racial individuals.to one of the most ethnically and culturally diverse U.S. populations. MDC, however, is not yet represented in the ECHO Program. Our diverse, multi-disciplinary team has access to the largest populations of pregnant women and those giving birth in MDC, and to community-based infrastructures caring for the most vulnerable women in the region for over 40 years. Furthermore, to advance ECHO science, we will address these aims: A) Examine social environment and placental genome influences on children's neurodevelopment and global health. We will determine whether the placental genome mediates the relationship between pre- and perinatal social environment and children's neurodevelopment and global health during early and middle childhood; and identify the interactive (gene x epigene x social environment) effects on children's neurodevelopment and global health during early and middle childhood. B) Identify factors that protect against the effects of discrimination on children's neurodevelopment and global health. We will distinguish the effects of maternal and paternal discrimination – separately and in combination – on children's neurodevelopment and global health from early to middle childhood; and determine the degree to which the social environment, social identity (race, ethnicity, skin color, nativity), and social support mediate the effects of discrimination on children's neurodevelopment and global health. C) Identify the effects of modifiable social determinants of health and access to family planning during the pre-conception period on subsequent pregnancy morbidity and birth outcomes.

项目摘要/摘要 母子健康的差异在产生中增加，因为母亲所经历的压力可能是 转移到孩子，既有生物学和心理后果。没有明确的理解 推动这些不同结果的因素，没有种族和种族的纵向评估 团体，不平等将持续存在。环境对儿童健康成果的影响（ECHO）计划的目的 了解早期环境因素对儿童健康和发展的影响，因此需要 多样化的儿童及其父母代表了各种各样的美国人口，尤其是种族和 经常在社会经济广告和社会压力源的交汇处的少数民族人口 与种族/种族有关。我们建议建立大致和种族的迈阿密校园队列 母亲，孩子和父亲。我们将招募和保留大致和种族多样的孕妇队列 妇女（n = 1,250），其后代和来自佛罗里达州迈阿密戴德县（MDC）的构想父亲。此外， 我们将招募并将60-80％的同类母亲招募到Echo先入率的试点方案中。 MDC是一个 少数族裔多数人数为69.4％的西班牙裔/拉丁美洲人（包括非洲加勒比海），非洲人为17.7％ 美国人，12.9％的非西班牙裔白人，3％的亚洲人和1.3％的多种族个人。 种族和文化上的美国人口。但是，MDC尚未在ECHO程序中代表。 我们的潜水员多学科团队可以使用最大的孕妇人群 MDC的出生以及基于社区的基础设施，照顾该地区最脆弱的妇女 超过40年。此外，为了推进回声科学，我们将解决这些目标：a）检查社会 环境和胎盘基因组对儿童神经发育和全球健康的影响。我们 将确定位置基因组是否介导了前和围产期社会之间的关系 童年和中期的环境和儿童神经发育和全球健康；并确定 互动式（基因X Epigene X社会环境）对儿童神经发育和全球健康的影响 在童年和中期。 b）确定防止歧视对影响的因素 儿童神经发育和全球健康。我们将区分母校和父亲的影响 从早期开始的歧视 - 分别和组合 - 关于儿童的神经发育和全球健康 到童年；并确定社会环境，社会身份（种族，种族， 肤色，诞生）和社会支持介导歧视对儿童神经发育和 全球健康。 c）确定可修改的社会决定者的健康和与家人的机会的影响 在概念前的计划，以随后的怀孕发病率和出生结果。