Miami-ECHO: A Diverse Cohort of Mothers, Children and Fathers in Miami-Dade County

项目总结/摘要 母婴健康的差距会随着世代而增加，因为母亲所经历的压力可能会 转移到他们的孩子身上，造成生物和心理后果。没有明确的认识 没有跨种族和族裔的纵向评估， 不平等将继续存在。环境对儿童健康结果的影响（ECHO） 了解早期环境因素对儿童健康和发育的影响，因此需要 一个多样化的儿童和他们的父母群体，代表了美国人口的多样性，特别是种族和 少数民族人口往往处于社会经济逆境和社会压力的交叉点 与种族/民族有关。我们建议建立迈阿密-ECHO队列， 母亲孩子和父亲我们将招募并保留一批不同种族和民族的孕妇， 女性（N= 1，250），她们的后代，以及来自佛罗里达迈阿密-戴德县（MDC）的怀孕父亲。此外，本发明还提供了一种方法， 我们将招募并保留60-80%的队列母亲参加ECHO孕前试点方案。MDC是一个 少数民族占多数的县，人口69.4%为西班牙裔/拉丁裔（包括非洲裔加勒比人），17.7%为非洲人 美国人，12.9%非西班牙裔白人，3%亚洲人，1.3%多种族individuals.to 种族和文化多样的美国人口。然而，争取民主变革运动尚未参加欧共体人道处方案。 我们多元化的多学科团队能够接触到最多的孕妇和孕妇， 在MDC分娩，并以社区为基础的基础设施照顾该地区最脆弱的妇女， 超过40年此外，为了推进ECHO科学，我们将解决这些目标：A）检查社会 环境和胎盘基因组对儿童神经发育和全球健康的影响。我们 将决定胎盘基因组是否介导产前和围产期社会关系， 儿童早期和中期的环境和儿童的神经发育和全球健康;并确定 互动（基因x表观基因x社会环境）对儿童神经发育和全球健康的影响 在童年早期和中期。B）查明保护妇女免受歧视影响的因素， 儿童神经发育与全球健康我们将区分母亲和父亲的影响 歧视-单独和组合-对儿童神经发育和全球健康的影响 到童年中期;并确定社会环境，社会身份（种族，民族， 肤色、出生地）和社会支持介导了歧视对儿童神经发育的影响， 全球健康。C）确定可改变的健康和获得家庭服务的社会决定因素的影响 在怀孕前阶段就随后的怀孕发病率和生育结果进行规划。

PROJECT SUMMARY/ABSTRACT Disparities in maternal-child health increase generationally because stress experienced by mothers can be transferred to their children, with both biological and psychological consequences. Without clear understanding of factors driving these disparate outcomes and without longitudinal assessments across racial and ethnic groups, inequities will persist. The Environmental influences on Child Health Outcomes (ECHO) Program aims to understand the effects of early environmental factors on child health and development, and therefore needs a diverse cohort of children and their parents who represent the variety of U.S. populations, especially racial and ethnic minority populations who often are at the intersection of socioeconomic adversity and social stressors related to race/ethnicity. We propose to establish the Miami-ECHO cohort of racially and ethnically diverse mothers, children, and fathers. We will recruit and retain a racially and ethnically diverse cohort of pregnant women (N=1,250), their offspring, and the conceiving father from Miami-Dade County (MDC), Florida. In addition, we will recruit and retain 60-80% of the cohort mothers into the ECHO preconception pilot protocol. MDC is a minority-majority county with a population of 69.4% Hispanic/Latinos (including Afro-Caribbeans), 17.7% African Americans, 12.9% Non-Hispanic Whites, 3% Asians, and 1.3% multi-racial individuals.to one of the most ethnically and culturally diverse U.S. populations. MDC, however, is not yet represented in the ECHO Program. Our diverse, multi-disciplinary team has access to the largest populations of pregnant women and those giving birth in MDC, and to community-based infrastructures caring for the most vulnerable women in the region for over 40 years. Furthermore, to advance ECHO science, we will address these aims: A) Examine social environment and placental genome influences on children's neurodevelopment and global health. We will determine whether the placental genome mediates the relationship between pre- and perinatal social environment and children's neurodevelopment and global health during early and middle childhood; and identify the interactive (gene x epigene x social environment) effects on children's neurodevelopment and global health during early and middle childhood. B) Identify factors that protect against the effects of discrimination on children's neurodevelopment and global health. We will distinguish the effects of maternal and paternal discrimination – separately and in combination – on children's neurodevelopment and global health from early to middle childhood; and determine the degree to which the social environment, social identity (race, ethnicity, skin color, nativity), and social support mediate the effects of discrimination on children's neurodevelopment and global health. C) Identify the effects of modifiable social determinants of health and access to family planning during the pre-conception period on subsequent pregnancy morbidity and birth outcomes.