Miami-ECHO: A Diverse Cohort of Mothers, Children and Fathers in Miami-Dade County

迈阿密-ECHO：迈阿密-戴德县的母亲、儿童和父亲的多元化群体

• 批准号: 10746614
• 负责人: Michael John Paidas
• 金额: $ 235.49万
• 依托单位: UNIVERSITY OF MIAMI CORAL GABLES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10746614
• 关键词: Address; Affect; African American population; African Caribbean; Age; Area; Asian population; Automobile Driving; Biological; Biological Process; Birth; Caring; Child; Child Development; Child Health; Childhood; Cohort Studies; Communities; Complex; Conceptions; County; Data; Discipline; Discrimination; Disease susceptibility; Disparity; Disparity population; Economics; Elderly; Environmental Risk Factor; Ethnic Origin; Ethnic Population; Family Planning; Fathers; Florida; Funding; Genes; Genome; Goals; Haitian; Health; Hispanic; Home; Individual; Inequity; Infant Health; Infrastructure; Insurance Coverage; Language; Latino Population; Life Experience; Linguistics; Maternal and Child Health; Mediating; Minority; Minority Women; Morbidity - disease rate; Mothers; Not Hispanic or Latino; Outcome; Parents; Perinatal; Persons; Population; Population Distributions; Population Heterogeneity; Poverty; Pregnancy; Pregnant Women; Protocols documentation; Race; Research; Role; Science; Scientific Advances and Accomplishments; Shapes; Social Environment; Social Identification; Social support; Stress; United States National Institutes of Health; Woman; Work; cohort; disorder risk; early childhood; ethnic diversity; ethnic minority; ethnic minority population; experience; global health; health disparity; improved; infant death; member; metropolitan; middle childhood; multi-racial; multidisciplinary; neurodevelopment; offspring; outcome disparities; perinatal period; prenatal; programs; psychologic; racial diversity; racial minority; racial minority population; racial population; racism; recruit; skin color; social; social genomics; social health determinants; social stressor; socioeconomic adversity

PROJECT SUMMARY/ABSTRACT Disparities in maternal-child health increase generationally because stress experienced by mothers can be transferred to their children, with both biological and psychological consequences. Without clear understanding of factors driving these disparate outcomes and without longitudinal assessments across racial and ethnic groups, inequities will persist. The Environmental influences on Child Health Outcomes (ECHO) Program aims to understand the effects of early environmental factors on child health and development, and therefore needs a diverse cohort of children and their parents who represent the variety of U.S. populations, especially racial and ethnic minority populations who often are at the intersection of socioeconomic adversity and social stressors related to race/ethnicity. We propose to establish the Miami-ECHO cohort of racially and ethnically diverse mothers, children, and fathers. We will recruit and retain a racially and ethnically diverse cohort of pregnant women (N=1,250), their offspring, and the conceiving father from Miami-Dade County (MDC), Florida. In addition, we will recruit and retain 60-80% of the cohort mothers into the ECHO preconception pilot protocol. MDC is a minority-majority county with a population of 69.4% Hispanic/Latinos (including Afro-Caribbeans), 17.7% African Americans, 12.9% Non-Hispanic Whites, 3% Asians, and 1.3% multi-racial individuals.to one of the most ethnically and culturally diverse U.S. populations. MDC, however, is not yet represented in the ECHO Program. Our diverse, multi-disciplinary team has access to the largest populations of pregnant women and those giving birth in MDC, and to community-based infrastructures caring for the most vulnerable women in the region for over 40 years. Furthermore, to advance ECHO science, we will address these aims: A) Examine social environment and placental genome influences on children's neurodevelopment and global health. We will determine whether the placental genome mediates the relationship between pre- and perinatal social environment and children's neurodevelopment and global health during early and middle childhood; and identify the interactive (gene x epigene x social environment) effects on children's neurodevelopment and global health during early and middle childhood. B) Identify factors that protect against the effects of discrimination on children's neurodevelopment and global health. We will distinguish the effects of maternal and paternal discrimination – separately and in combination – on children's neurodevelopment and global health from early to middle childhood; and determine the degree to which the social environment, social identity (race, ethnicity, skin color, nativity), and social support mediate the effects of discrimination on children's neurodevelopment and global health. C) Identify the effects of modifiable social determinants of health and access to family planning during the pre-conception period on subsequent pregnancy morbidity and birth outcomes.

项目摘要/摘要 母婴健康方面的差距代际增加，因为母亲所经历的压力可能是 转移到他们的孩子身上，造成生理和心理上的后果。没有明确的认识 驱动这些不同结果的因素，而不是跨种族和民族的纵向评估 但是，不平等现象仍将持续存在。环境对儿童健康结果的影响(ECHO)项目目标 了解早期环境因素对儿童健康和发育的影响，因此需要 代表美国人口的多样性的儿童和他们的父母的队列，特别是种族和 少数民族人口往往处于社会经济逆境和社会压力的交汇点 与种族/民族有关。我们建议建立迈阿密回声的种族和民族多元化队列 母亲、孩子和父亲。我们将招募和保留一批不同种族和民族的孕妇 来自佛罗里达州迈阿密-戴德县(MDC)的妇女(N=1,250)及其后代和怀孕的父亲。此外, 我们将招募和保留60%-80%的队列母亲加入ECHO先孕试点方案。MDC是一种 少数民族占多数的县，人口69.4%为西班牙裔/拉丁裔(包括非洲裔加勒比人)，17.7%为非洲人 美国人，12.9%的非西班牙裔白人，3%的亚洲人，1.3%的多种族个人。 种族和文化多元化的美国人口。然而，MDC还没有出现在ECHO计划中。 我们多元化、多学科的团队可以接触到最大规模的孕妇和那些 在争取民主变革运动中出生，以及以社区为基础的基础设施，照顾该区域最脆弱的妇女 40多年了。此外，为了促进回声科学，我们将解决这些目标：a)审查社会 环境和胎盘基因组对儿童神经发育和全球健康的影响。我们 将决定胎盘基因组是否在产前和围产期社会关系中起中介作用 儿童早期和中期的环境与儿童的神经发展和全球健康； 交互作用(基因x后生x社会环境)对儿童神经发育和全球健康的影响 在童年早期和中期。B)确定防止歧视的影响的因素 儿童神经发育和全球健康。我们将区分母性和父性的影响 从早年起对儿童神经发育和全球健康的歧视--单独和联合 到童年中期；并确定社会环境、社会认同(种族、民族、 肤色、出生地)和社会支持在歧视对儿童神经发育和 全球健康。C)确定健康和获得家庭机会的可改变的社会决定因素的影响 在怀孕前阶段对随后的妊娠发病率和分娩结果进行规划。