The Biological Cost of External and Internal Resilience Factors in Trauma Survivors
创伤幸存者外部和内部复原因素的生物成本
基本信息
- 批准号:10748472
- 负责人:
- 金额:$ 6.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:2 year oldAccelerationAccident and Emergency departmentAcute Post Traumatic Stress DisorderAgeAgingBiologicalBiological AgingBlood specimenBrainBuffersCell physiologyChronologyClinicalCognitiveCommunicationDNA MethylationDataData SetDevelopmentDiseaseEarly InterventionEmotionalEpigenetic ProcessExposure toFamilyFellowshipFutureGene ExpressionGeneticGoalsHealth StatusIncomeIndividualInjuryInterventionKnowledgeLongevityMachine LearningMagnetic Resonance ImagingMeasuresMediatingMediationMentorshipOutcomeParticipantPatternPolicy MakerPopulationPost-Traumatic Stress DisordersPredispositionPreventionProcessPsychiatric epidemiologyPublic HealthRecoveryRecurrenceResearchResearch PersonnelResourcesRiskSamplingSocial EnvironmentSouth AfricaSouth AfricanStressSurvivorsSymptomsSystemTechniquesTestingTherapeuticThickTrainingTraumaTraumatic injuryUnited StatesWomanWorkacute symptomadverse outcomeagedbiological systemsclinical trainingcohortcostcost comparisoncultural competencedesignepigenomicsexperiencegray matterimprovedinterestlongitudinal datasetmachine learning modelmultimodal dataneuralneuroimagingneuropsychiatrynew therapeutic targetnovel therapeutic interventionpharmacologicpost-traumapost-traumatic symptomspreventprovider factorspsychologicrecruitresilienceresilience factorresilience scaleskillssocialstressortrauma exposuretraumatic event
项目摘要
PROJECT SUMMARY/ABSTRACT
Over 70% of individuals world-wide have been exposed to at least one traumatic event and a significant subset
will develop posttraumatic stress disorder (PTSD). The biological cost of trauma is evident in the excessive “wear
and tear” on biological systems which can accelerate aging of neural and cellular processes. For example, the
brains of individuals with PTSD appear 1-2 years older than same-aged counterparts without PTSD. Trauma
exposure also modifies gene expression through the accumulation of DNA methylation. DNA methylation levels
increase with chronological age but this “epigenetic clock” is accelerated by traumatic events. Despite these
negative effects, the majority of trauma-exposed individuals do not develop PTSD. Certain individual strengths
or socioenvironmental resources increase the likelihood of overcoming the impact of trauma. These resilience
factors may help buffer against trauma-related accelerated brain and epigenetic aging. However, there may be
hidden biological costs associated with these factors, especially for individuals who experience more severe
symptoms acutely post-trauma. This project tests whether, in trauma survivors, internal resources have a
significantly higher biological cost compared to external resources. Using a large longitudinal dataset (the
AURORA study) of traumatically injured individuals recruited from Emergency Departments across the United
States, we will test the associations between external resilience (operationalized as higher income), internal
resilience (operationalized as higher scores on the Connor-Davidson Resilience Scale), and accelerated brain
(brainAGE; Aim 1) and epigenetic aging (epiAGE; Aim 2). We anticipate that brainAGE and epiAGE will mediate
the relationship between resilience factors and future PTSD symptoms (6-months post-injury). Importantly, we
anticipate an individual’s acute PTSD symptoms (2-weeks post-injury) will moderate these relationships.
Participants with more severe 2-week PTSD symptoms and higher internal resilience will show greater brainAGE
and epiAGE whereas participants with similar symptoms and higher external resilience will display more typical
aging patterns. In Aim 3, we will test the relationship between brainAGE, PTSD, and resilience factors in a South
African cohort of women with recurrent trauma exposure to evaluate generalizability. The training goals of this
fellowship were designed to further the applicant’s knowledge and skills in: 1) advanced neuroimaging analyses,
2) epigenomic approaches for neuropsychiatric research, 3) clinical understanding of PTSD, 4) cultural
competency in epidemiologic psychiatric research, and 5) scientific communication and effective mentorship.
These results will inform the treatment and prevention of PTSD. By better understanding how resiliency is
promoted biologically, pharmacological therapeutics may be developed that boost the endogenous resilience
mechanisms. In addition, the findings may improve post-trauma interventions at a public health level by
illustrating the types of resilience factors that clinicians and policy makers should target.
项目总结/文摘
项目成果
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