The Biological Cost of External and Internal Resilience Factors in Trauma Survivors
创伤幸存者外部和内部复原因素的生物成本
基本信息
- 批准号:10748472
- 负责人:
- 金额:$ 6.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:2 year oldAccelerationAccident and Emergency departmentAcute Post Traumatic Stress DisorderAgeAgingBiologicalBiological AgingBlood specimenBrainBuffersCell physiologyChronologyClinicalCognitiveCommunicationDNA MethylationDataData SetDevelopmentDiseaseEarly InterventionEmotionalEpigenetic ProcessExposure toFamilyFellowshipFutureGene ExpressionGeneticGoalsHealth StatusIncomeIndividualInjuryInterventionKnowledgeLongevityMachine LearningMagnetic Resonance ImagingMeasuresMediatingMediationMentorshipOutcomeParticipantPatternPolicy MakerPopulationPost-Traumatic Stress DisordersPredispositionPreventionProcessPsychiatric epidemiologyPublic HealthRecoveryRecurrenceResearchResearch PersonnelResourcesRiskSamplingSocial EnvironmentSouth AfricaSouth AfricanStressSurvivorsSymptomsSystemTechniquesTestingTherapeuticThickTrainingTraumaTraumatic injuryUnited StatesWomanWorkacute symptomadverse outcomeagedbiological systemsclinical trainingcohortcostcost comparisoncultural competencedesignepigenomicsexperiencegray matterimprovedinterestlongitudinal datasetmachine learning modelmultimodal dataneuralneuroimagingneuropsychiatrynew therapeutic targetnovel therapeutic interventionpharmacologicpost-traumapost-traumatic symptomspreventprovider factorspsychologicrecruitresilienceresilience factorresilience scaleskillssocialstressortrauma exposuretraumatic event
项目摘要
PROJECT SUMMARY/ABSTRACT
Over 70% of individuals world-wide have been exposed to at least one traumatic event and a significant subset
will develop posttraumatic stress disorder (PTSD). The biological cost of trauma is evident in the excessive “wear
and tear” on biological systems which can accelerate aging of neural and cellular processes. For example, the
brains of individuals with PTSD appear 1-2 years older than same-aged counterparts without PTSD. Trauma
exposure also modifies gene expression through the accumulation of DNA methylation. DNA methylation levels
increase with chronological age but this “epigenetic clock” is accelerated by traumatic events. Despite these
negative effects, the majority of trauma-exposed individuals do not develop PTSD. Certain individual strengths
or socioenvironmental resources increase the likelihood of overcoming the impact of trauma. These resilience
factors may help buffer against trauma-related accelerated brain and epigenetic aging. However, there may be
hidden biological costs associated with these factors, especially for individuals who experience more severe
symptoms acutely post-trauma. This project tests whether, in trauma survivors, internal resources have a
significantly higher biological cost compared to external resources. Using a large longitudinal dataset (the
AURORA study) of traumatically injured individuals recruited from Emergency Departments across the United
States, we will test the associations between external resilience (operationalized as higher income), internal
resilience (operationalized as higher scores on the Connor-Davidson Resilience Scale), and accelerated brain
(brainAGE; Aim 1) and epigenetic aging (epiAGE; Aim 2). We anticipate that brainAGE and epiAGE will mediate
the relationship between resilience factors and future PTSD symptoms (6-months post-injury). Importantly, we
anticipate an individual’s acute PTSD symptoms (2-weeks post-injury) will moderate these relationships.
Participants with more severe 2-week PTSD symptoms and higher internal resilience will show greater brainAGE
and epiAGE whereas participants with similar symptoms and higher external resilience will display more typical
aging patterns. In Aim 3, we will test the relationship between brainAGE, PTSD, and resilience factors in a South
African cohort of women with recurrent trauma exposure to evaluate generalizability. The training goals of this
fellowship were designed to further the applicant’s knowledge and skills in: 1) advanced neuroimaging analyses,
2) epigenomic approaches for neuropsychiatric research, 3) clinical understanding of PTSD, 4) cultural
competency in epidemiologic psychiatric research, and 5) scientific communication and effective mentorship.
These results will inform the treatment and prevention of PTSD. By better understanding how resiliency is
promoted biologically, pharmacological therapeutics may be developed that boost the endogenous resilience
mechanisms. In addition, the findings may improve post-trauma interventions at a public health level by
illustrating the types of resilience factors that clinicians and policy makers should target.
项目概要/摘要
全球超过 70% 的人至少经历过一次创伤事件,并且其中很大一部分人曾经历过
会发展为创伤后应激障碍(PTSD)。创伤的生物成本在过度的“磨损”中显而易见
和撕裂”对生物系统的影响,可以加速神经和细胞过程的衰老。例如,
患有 PTSD 的人的大脑比没有 PTSD 的同龄人要老 1-2 岁。创伤
暴露还通过 DNA 甲基化的积累来改变基因表达。 DNA甲基化水平
随着实际年龄的增长,这种“表观遗传时钟”会因创伤事件而加速。尽管有这些
负面影响,大多数遭受创伤的人不会患上创伤后应激障碍(PTSD)。某些个人优势
或社会环境资源增加了克服创伤影响的可能性。这些韧性
这些因素可能有助于缓冲与创伤相关的加速大脑和表观遗传衰老。然而,可能有
与这些因素相关的隐性生物成本,特别是对于经历更严重的个体
外伤后出现急性症状。该项目测试了创伤幸存者的内部资源是否具有
与外部资源相比,生物成本显着更高。使用大型纵向数据集(
AURORA 研究)针对从美国各地急诊科招募的外伤人员
国家,我们将测试外部弹性(可操作为更高的收入)与内部弹性之间的关联
复原力(在康纳戴维森复原力量表上表现为更高的分数)和加速的大脑
(brainAGE;目标 1)和表观遗传衰老(epiAGE;目标 2)。我们预计 BrainAGE 和 epiAGE 将介导
复原力因素与未来 PTSD 症状(受伤后 6 个月)之间的关系。重要的是,我们
预计一个人的急性创伤后应激障碍症状(受伤后两周)会缓和这些关系。
具有更严重的 2 周 PTSD 症状和更高的内部复原力的参与者将表现出更高的 BrainAGE
和 epiAGE 而具有相似症状和较高外部复原力的参与者将表现出更典型的
老化模式。在目标 3 中,我们将测试南方地区的 BrainAGE、PTSD 和复原力因素之间的关系
非洲经常遭受创伤的妇女队列评估普遍性。本次培训目标
奖学金旨在进一步提高申请人在以下方面的知识和技能:1)高级神经影像分析,
2) 神经精神病学研究的表观基因组方法,3) 对 PTSD 的临床理解,4) 文化
流行病学精神病学研究的能力,以及 5) 科学沟通和有效的指导。
这些结果将为创伤后应激障碍的治疗和预防提供信息。通过更好地理解弹性是如何
在生物学上促进,可以开发药理学疗法来增强内源性恢复力
机制。此外,研究结果可能会改善公共卫生层面的创伤后干预措施
说明临床医生和政策制定者应瞄准的复原力因素类型。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Elisabeth Kathleen Webb其他文献
Elisabeth Kathleen Webb的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
SHINE: Origin and Evolution of Compressible Fluctuations in the Solar Wind and Their Role in Solar Wind Heating and Acceleration
SHINE:太阳风可压缩脉动的起源和演化及其在太阳风加热和加速中的作用
- 批准号:
2400967 - 财政年份:2024
- 资助金额:
$ 6.91万 - 项目类别:
Standard Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328975 - 财政年份:2024
- 资助金额:
$ 6.91万 - 项目类别:
Continuing Grant
EXCESS: The role of excess topography and peak ground acceleration on earthquake-preconditioning of landslides
过量:过量地形和峰值地面加速度对滑坡地震预处理的作用
- 批准号:
NE/Y000080/1 - 财政年份:2024
- 资助金额:
$ 6.91万 - 项目类别:
Research Grant
Market Entry Acceleration of the Murb Wind Turbine into Remote Telecoms Power
默布风力涡轮机加速进入远程电信电力市场
- 批准号:
10112700 - 财政年份:2024
- 资助金额:
$ 6.91万 - 项目类别:
Collaborative R&D
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328973 - 财政年份:2024
- 资助金额:
$ 6.91万 - 项目类别:
Continuing Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328972 - 财政年份:2024
- 资助金额:
$ 6.91万 - 项目类别:
Continuing Grant
Collaborative Research: A new understanding of droplet breakup: hydrodynamic instability under complex acceleration
合作研究:对液滴破碎的新认识:复杂加速下的流体动力学不稳定性
- 批准号:
2332916 - 财政年份:2024
- 资助金额:
$ 6.91万 - 项目类别:
Standard Grant
Collaborative Research: A new understanding of droplet breakup: hydrodynamic instability under complex acceleration
合作研究:对液滴破碎的新认识:复杂加速下的流体动力学不稳定性
- 批准号:
2332917 - 财政年份:2024
- 资助金额:
$ 6.91万 - 项目类别:
Standard Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328974 - 财政年份:2024
- 资助金额:
$ 6.91万 - 项目类别:
Continuing Grant
Radiation GRMHD with Non-Thermal Particle Acceleration: Next-Generation Models of Black Hole Accretion Flows and Jets
具有非热粒子加速的辐射 GRMHD:黑洞吸积流和喷流的下一代模型
- 批准号:
2307983 - 财政年份:2023
- 资助金额:
$ 6.91万 - 项目类别:
Standard Grant














{{item.name}}会员




