NIH Gonzalez-Amoretti Characterizing PopulationDynamics of Prefrontal Cortex which Govern the Modulation of Visual Processing

NIH Gonzalez-Amoretti 描述了控制视觉处理调节的前额叶皮层的群体动态

基本信息

  • 批准号:
    10748169
  • 负责人:
  • 金额:
    $ 4.77万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-08-21 至 2027-08-20
  • 项目状态:
    未结题

项目摘要

Project Summary/Abstract The prefrontal cortex (PFC) is widely reported to play a role in visual attention, employed through modulation of neuronal activity in visual processing regions, such as V4 and MT. Sub-regions within the PFC of monkeys, such as the frontal eye fields (FEF) and the ventral prearcuate region (VPA), are reported to govern spatial and feature-based attentional modulation of visual responses, respectively. However, the cellular-level circuitry and neurocomputational mechanisms involved in the modulatory control of visual processing remain unclear. Previous work suggests that interactions between diverse sub-populations in both FEF and VPA may facilitate modulation of visual processing signals as well as shifts of attention, but this remains untested. The purpose of my project is to determine the neuronal dynamics within sub-regions in PFC that govern top- down modulation of visual processing. It is possible, that FEF may integrate signals representing object identity which arise in VPA and transforms them to signals representing spatial locations of a target stimulus. We plan on addressing this hypothesis by: (1) characterizing the spatial- and feature-tuning properties of FEF in the context of visual search to understand how integration and transformation of attentional signals may be implemented; (2) establishing the temporal dynamics between FEF and VPA to reveal the nature of neuronal communication between both regions during visual search; and (3) determine the causal role of VPA towards feature-based attentional modulation of visual processing via reversible pharmacologic inactivation. Monkeys are trained on a visual search task designed to conditionally engage attentional processes that are dependent on feature or spatial information. Using neurophysiology and population analyses, we will determine the neuronal correlates of PFC which govern the computational processes needed to accomplish these tasks. These findings will provide a description of the circuit-level mechanisms involved in top-down attention which often times is affected in neuropsychological disorders and neurodegenerative diseases. Thus, this project aims to contribute knowledge concerning the neuronal correlates of visual processing that are involved in related underlying symptoms. Additionally, learning about how higher-level brain regions modulate visual processing may provide more information about how perception is conjured in the brain. My environment at UR fosters the opportunity to broaden my research skillset which ultimately facilitates my endeavor towards my career goal as a scientific leader pushing to improve our approach of intervening with mental illnesses. The social environment at UR provides great opportunity for outreach, allowing me to fulfill my aspirations as a community leader looking to pave a way for underrepresented individuals which get overlooked given their backgrounds.
项目总结/摘要 前额叶皮层(PFC)被广泛报道在视觉注意中发挥作用,通过调制 视觉处理区域的神经元活动,如V4和MT。猴子PFC内的次区域, 如前眼区(FEF)和腹前弓状区(VPA),据报道, 基于特征的视觉反应的注意力调制,分别。然而,细胞级电路和 涉及视觉处理的调节控制的神经计算机制仍不清楚。 先前的工作表明,FEF和VPA中不同亚群之间的相互作用可能有助于 视觉处理信号的调制以及注意力的转移,但这仍然未经测试。目的 我的项目的一部分是确定PFC中控制顶部的子区域内的神经元动力学, 视觉处理的向下调制。可能的是,FEF可以整合表示对象的信号, 在VPA中出现的身份并将其转换为代表目标刺激的空间位置的信号。 我们计划通过以下方式解决这一假设:(1)表征FEF的空间和特征调谐特性 在视觉搜索的背景下,了解注意力信号的整合和转换可能是 (2)建立FEF和VPA之间的时间动力学,以揭示神经元的本质。 视觉搜索过程中两个区域之间的通信;(3)确定VPA对 通过可逆的药理学失活对视觉处理进行基于特征的注意力调节。猴子 在视觉搜索任务上进行训练,该任务旨在有条件地参与依赖于 特征或空间信息。使用神经生理学和群体分析,我们将确定神经元 PFC的相关性,它控制着完成这些任务所需的计算过程。这些发现 将提供一个描述电路级机制涉及自上而下的注意力,往往是 影响神经心理障碍和神经退行性疾病。因此,本项目旨在为 关于视觉处理的神经元相关的知识,涉及相关的潜在的 症状此外,了解更高层次的大脑区域如何调节视觉处理可以提供 更多关于感知如何在大脑中产生的信息。我在UR的环境促进了机会 拓宽我的研究技能,最终促进我奋进实现我的职业目标,作为一个科学家, 领导人推动改善我们干预精神疾病的方法。UR的社会环境 提供了一个很好的机会,让我实现我的愿望,作为一个社区领袖, 为代表性不足的个人铺平道路,因为他们的背景而被忽视。

项目成果

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John Carl Gonzalez-Amoretti其他文献

John Carl Gonzalez-Amoretti的其他文献

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