Connectivity and function of inhibitory neurons in the primate visual cortex

灵长类视觉皮层抑制性神经元的连接和功能

基本信息

  • 批准号:
    10745862
  • 负责人:
  • 金额:
    $ 9.69万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-30 至 2025-06-30
  • 项目状态:
    未结题

项目摘要

SUMMARY The goals and specific aims of the present Administrative Supplement application are unchanged with respect to the parent R01 award. Here we request additional funds for unanticipated expenses within the original scope of the project. In the original application we proposed to use viral vectors that specifically infect somatostatin (SOM) and parvalbumin (PV) inhibitory neurons in non-human primate cortex. These viral vectors were generated and provided by our collaborators Dr Zemelman at UT Austin (a subcontract PI in the first two years of the project), Dr Dimidschstein (Broad Institute), and Dr Horwitz (Univ. of Washington). In the first two years of the project, we tested and validated the 3 types of PV-specific viruses generated by our collaborators. Dr Dimidschstein’s virus showed the highest specificity for PV neurons. Unfortunately, however, Dr Dimidschstein has recently left academia and is no longer in a position to provide us with this vector and its variants at no cost. We have, therefore, started a collaboration with Drs Gordon Fishell (Harvard) and Dr. Gabrielle Pouchelon (Cold Spring Harbor) to generate variants of the Dimidschstein PV-specific virus that express the necessary genes to perform the TRIO experiments proposed in Aim 1 of the project, to trace anatomical inputs to PV cells. Moreover, we are working with private companies (Genewiz and Addgene) and the U Penn Viral Vector Core to generate variants of this PV-specific virus carrying the genes for excitatory and inhibitory opsins; these are necessary to address Aim 3 of the project. These new approaches require significant additional expenses which we cannot cover with the funds awarded. The requested cost increases would allow us to address part of Aim1 and Aim3 of the project using vectors with >90% specificity as validated by our studies performed in the initial years of the project. We will make accessible to the community the vectors generated with the additional funds.
总结

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Alessandra Angelucci其他文献

Alessandra Angelucci的其他文献

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{{ truncateString('Alessandra Angelucci', 18)}}的其他基金

High density chronic optogenetic interface for primate brains
灵长类大脑的高密度慢性光遗传学接口
  • 批准号:
    10706899
  • 财政年份:
    2023
  • 资助金额:
    $ 9.69万
  • 项目类别:
Connectivity and function of inhibitory neurons in the primate visual cortex
灵长类视觉皮层抑制性神经元的连接和功能
  • 批准号:
    10434932
  • 财政年份:
    2020
  • 资助金额:
    $ 9.69万
  • 项目类别:
Connectivity and function of inhibitory neurons in the primate visual cortex
灵长类视觉皮层抑制性神经元的连接和功能
  • 批准号:
    10256055
  • 财政年份:
    2020
  • 资助金额:
    $ 9.69万
  • 项目类别:
Connectivity and function of inhibitory neurons in the primate visual cortex
灵长类视觉皮层抑制性神经元的连接和功能
  • 批准号:
    10662206
  • 财政年份:
    2020
  • 资助金额:
    $ 9.69万
  • 项目类别:
Medical Student Research Program (MSRP) in Eye Health and Disease
眼健康和疾病医学生研究计划 (MSRP)
  • 批准号:
    10411366
  • 财政年份:
    2016
  • 资助金额:
    $ 9.69万
  • 项目类别:
Anatomical and functional organization of inter-areal feedback circuits in the visual cortex, and their impact on neuronal responses
视觉皮层区域间反馈回路的解剖和功能组织及其对神经元反应的影响
  • 批准号:
    10408773
  • 财政年份:
    2016
  • 资助金额:
    $ 9.69万
  • 项目类别:
Development of an integrated array for simultaneous optogenetic stimulation and electrical recording to study cortical circuit function in the non-human primate brain
开发用于同时光遗传学刺激和电记录的集成阵列,以研究非人类灵长类动物大脑中的皮质电路功能
  • 批准号:
    9547551
  • 财政年份:
    2016
  • 资助金额:
    $ 9.69万
  • 项目类别:
Development of an integrated array for simultaneous optogenetic stimulation and electrical recording to study cortical circuit function in the non-human primate brain
开发用于同步光遗传学刺激和电记录的集成阵列,以研究非人类灵长类动物大脑中的皮质电路功能
  • 批准号:
    9358355
  • 财政年份:
    2016
  • 资助金额:
    $ 9.69万
  • 项目类别:
Anatomical and functional organization of inter-areal feedback circuits in the visual cortex, and their impact on neuronal responses
视觉皮层区域间反馈回路的解剖和功能组织及其对神经元反应的影响
  • 批准号:
    9884765
  • 财政年份:
    2016
  • 资助金额:
    $ 9.69万
  • 项目类别:
Anatomical and functional organization of inter-areal feedback circuits in the visual cortex, and their impact on neuronal responses
视觉皮层区域间反馈回路的解剖和功能组织及其对神经元反应的影响
  • 批准号:
    10636827
  • 财政年份:
    2016
  • 资助金额:
    $ 9.69万
  • 项目类别:

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