Trajectories and Environments in Autism: a Multi-cohort Study (TEAMS) following autism families in ECHO Phase 2

自闭症的轨迹和环境：ECHO 第 2 阶段中对自闭症家庭进行的多队列研究 (TEAMS)

• 批准号: 10745068
• 负责人: KRISTEN Lyall
• 金额: $ 113.7万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745068
• 关键词: Abbreviations; Address; Adolescence; Adolescent; Adult; Age; Air Pollutants; Air Pollution; Area; Attention deficit hyperactivity disorder; Automobile Driving; Behavioral; Child; Child Health; Childhood; Cohort Studies; Collection; Communities; Cross-Sectional Studies; Data; Data Collection; Diagnosis; Diagnostic; Diet; Dietary Factors; Ensure; Environment; Environmental Exposure; Environmental Risk Factor; Etiology; Exposure to; Family; Fatty Acids; Fishes; Folic Acid; General Population; Genetic; Genetic Variation; Goals; Health; Healthcare; Healthy Eating; Heritability; Incentives; Intake; Intellectual functioning disability; Joints; Language; Life; Longevity; Longitudinal Studies; Measurement; Measures; Mental Health; Methods; Modification; Names; Neighborhoods; Neurodevelopmental Disorder; Nutrient; Outcome; Participant; Pattern; Personal Satisfaction; Phase; Phenotype; Play; Population; Prevalence; Property; Protocols documentation; Psyche structure; Psychometrics; Research; Resources; Risk; Risk Factors; Role; Sample Size; Science; Siblings; Site; Uterus; Work; adolescent health outcomes; adolescent with autism spectrum disorder; adult with autism spectrum disorder; age group; autism spectrum disorder; autistic; autistic children; care burden; cohort; dietary; dimensional analysis; early childhood; early life exposure; emerging adult; epidemiology study; follow-up; health assessment; indexing; individuals with autism spectrum disorder; neurodevelopment; outcome prediction; physical conditioning; polygenic risk score; prenatal; prenatal exposure; programs; recruit; retention rate; sex; support network; trait

Autism spectrum disorder (ASD) is one of the most common neurodevelopmental disorders diagnosed in childhood, with a prevalence of 2% or higher. ASD presents along a spectrum, and characterization according to quantitative measures demonstrates continuous distribution of core traits extending into the general population. While both ASD diagnosis and ASD-related traits have been shown to be highly heritable, evidence also supports contributions of environmental risk factors, including prenatal exposure to air pollution and intake of certain nutrients. In order to address prior gaps in the understanding of environmental risk factors for autism, our team developed the Autism Spectrum Disorder Enriched Risk (ASD-ER) “cohort of cohorts.” In the first phase of ECHO, our cohort contributed to harmonization efforts of diet, air pollution, and neurodevelopment, and advanced use of abbreviated measures of the ASD-related phenotype, while capitalizing on the unique data for autism research presented by ECHO. Here, we propose to build off of these efforts while continuing follow-up of ASD-ER ECHO Phase-1 children through the critical and under-studied period of adolescence and early adulthood in the Trajectories and Environments in Autism: a Multi-cohort Study (TEAMS) project. The goals of this project are to: 1) Examine joint effects of early life air pollution exposure and diet on neurodevelopmental outcomes in ECHO-wide data, addressing the role that folate, fish/fatty acids, and other dietary factors may play in mitigating air pollution associations across neurodevelopmental diagnoses and their related quantitative traits (ASD, ID, and ADHD); 2) Evaluate multi-domain health trajectories of adolescents across neurodevelopmental outcomes in ECHO-wide data, and identify predictors of positive trajectories and outcomes. Using the unique longitudinal data collected through ECHO efforts, we will examine trajectories across mental and physical health and examine how these differ across neurodevelopmental diagnoses and traits. We will also seek to further characterize our specialized outcome area of neurodevelopment, and autism specifically, by conducting psychometric analyses of dimensional measures. Finally, we will 3) Maximize recruitment and retention of our cohort participants via implementation of the ECHO protocol. We will implement a unified recruitment and retention strategy facilitated by incentives and a network of support for adolescents with neurodevelopmental conditions, transition-age autistic youth, and their families. TEAMS will be the first longitudinal study of autistic younger sibling children followed from the womb to adulthood. In doing so, our project presents unique opportunities to advance understanding of environmental predictors and modifiers, conduct cross-outcome comparisons of neurodevelopmental disorders and their latent traits, characterize multi-domain trajectories and identify predictors of positive outcomes in autistic adolescents, and implement the ECHO Phase 2 protocol to ensure an expanded set of research possibilities in this important population, and ultimately, optimize outcomes for autistic individuals and their families.

自闭症谱系障碍（ASD）是最常见的神经发育障碍之一 儿童时期，患病率达 2% 或更高。 ASD 呈现出一个频谱，并根据 定量测量表明核心特征的连续分布延伸到一般特征 人口。虽然自闭症谱系障碍 (ASD) 诊断和自闭症谱系障碍 (ASD) 相关特征均已被证明具有高度遗传性，但有证据表明 还支持环境风险因素的贡献，包括产前接触空气污染和摄入 某些营养素。为了解决先前对自闭症环境风险因素理解上的差距， 我们的团队开发了自闭症谱系障碍丰富风险（ASD-ER）“队列中的队列”。在第一阶段 ECHO 的团队为协调饮食、空气污染和神经发育做出了贡献， 先进地使用 ASD 相关表型的简化测量，同时利用独特的数据 ECHO 提出的自闭症研究。在此，我们建议在这些努力的基础上继续跟进 ASD-ER ECHO 第一阶段儿童经历青春期和早期的关键和尚未充分研究的时期 自闭症轨迹和环境中的成年期：多队列研究 (TEAMS) 项目。的目标 该项目的目的是： 1) 检查生命早期空气污染暴露和饮食对 ECHO范围数据中的神经发育结果，解决叶酸、鱼/脂肪酸和其他物质的作用 饮食因素可能在减轻神经发育诊断及其相关的空气污染关联方面发挥作用 相关数量性状（ASD、ID 和 ADHD）； 2）评估青少年的多领域健康轨迹 跨越 ECHO 范围数据中的神经发育结果，并确定积极轨迹的预测因子 和结果。使用通过 ECHO 工作收集的独特纵向数据，我们将检查轨迹 涵盖心理和身体健康，并检查这些在神经发育诊断和诊断中有何不同 特征。我们还将寻求进一步描述我们的神经发育专业成果领域的特征，以及 特别是自闭症，通过对维度测量进行心理测量分析。最后，我们将 3) 最大化 通过实施 ECHO 协议来招募和保留我们的队列参与者。我们将 实施统一的招聘和保留战略，并通过激励措施和支持网络推动 患有神经发育疾病的青少年、过渡时期的自闭症青少年及其家人。团队将 第一项针对自闭症弟弟妹妹的纵向研究是从子宫到成年。在 这样做，我们的项目提供了独特的机会来增进对环境预测因素的理解和 修饰符，对神经发育障碍及其潜在特征进行交叉结果比较， 描述多领域轨迹的特征并确定自闭症青少年积极结果的预测因素，以及 实施 ECHO 第 2 阶段协议，以确保在这一重要领域扩大研究可能性 人口，并最终优化自闭症患者及其家庭的结果。