Early intervention as a determinant of hearing aid benefit for age-related hearing loss: Results from longitudinal cohort studies

早期干预是助听器对年龄相关性听力损失有益的决定因素：纵向队列研究的结果

• 批准号: 10749385
• 负责人: Lauren Kay Dillard
• 金额: $ 7.61万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10749385
• 关键词: Address; Adult; Age; Aging; Apple; Audiology; Chronic; Clinical; Clinical Trials; Cognition; Cognitive; Cohort Studies; Communication; Communities; Data; Development; Diagnosis; Early Intervention; Educational process of instructing; Engineering; Environment; Epidemiology; Funding; Future; General Population; Goals; Health; Health Personnel; Health Promotion; Hearing; Hearing Aids; Individual; Intervention; Knowledge; Longitudinal cohort study; Measures; Medical; Medicine; Mentors; Methods; National Institute on Deafness and Other Communication Disorders; Neuronal Plasticity; Outcome; Participant; Population Study; Presbycusis; Public Health; Randomized, Controlled Trials; Recommendation; Research; Research Personnel; Research Project Grants; Risk; Sampling; Secondary Prevention; Severities; South Carolina; Speech; Strategic Planning; Surveys; Testing; Time; Training; United States National Academy of Sciences; United States National Institutes of Health; Universities; Work; career; clinical practice; cognitive function; dalton; epidemiology study; evidence base; follow-up; frailty; hearing impairment; help-seeking behavior; human old age (65+); improved; population based; prospective; psychosocial; psychosocial wellbeing; public health priorities; public health research; screening; tertiary prevention; uptake

PROJECT SUMMARY/ABSTRACT Age-related hearing loss (ARHL) is a highly prevalent chronic condition and is associated with poorer psychosocial well-being, communication, and cognitive function. Evidence that hearing aid (HA) use mitigates negative consequences of ARHL is inconclusive because, in part, longitudinal population-based studies of hearing with sufficient follow-up times are rare and few have considered the extent to which earlier intervention with HA improves long-term HA outcomes and reduces the wide-ranging consequences of ARHL. The long- term objective is to reduce impacts of ARHL by maximizing overall HA benefit. The specific objective is to holistically assess benefits of HA use on psychosocial well-being, communication, and cognitive outcomes that capture general and hearing-specific health and determine the extent to which earlier intervention for ARHL is a determinant of HA benefit. To achieve this objective, two specific aims are proposed. Aim 1 will use longitudinal data from the Medical University of South Carolina (MUSC) Longitudinal Cohort Study of ARHL to determine benefits of HA use and assess contributions of early intervention and test hypotheses that a) use of HA will be associated with better general health aspects of psychosocial well-being, cognition, and communication, and b) earlier intervention with HA will be associated with greater HA benefit as determined by these outcomes. Aim 2 will use cross-temporal data to determine benefits of HA use and assess contributions of early intervention using historic and newly collected data from participants in the MUSC Longitudinal Cohort Study of ARHL to test hypotheses that a) use of HA will be associated with better hearing-specific psychosocial well-being and communication outcomes, and b) earlier intervention with HA will be associated with greater HA benefit as determined by these outcomes. Results from this project will positively impact public health research and clinical practice. Specifically, results can inform future epidemiological research and/or clinical trials aiming to determine effects of early intervention on HA benefit, optimal timing of HA interventions, and the appropriate age to begin screening for ARHL. This project and line of research directly addresses the National Academies of Sciences, Engineering, and Medicine (2016) recommendation to improve prospective population-based evidence on impacts of ARHL and its treatment and aligns with NIDCD’s strategic plan on secondary and tertiary prevention and health promotion for individuals with ARHL. That is, this proposal aims to determine importance of early intervention for ARHL (secondary prevention) and benefits of HA use (tertiary prevention) on general and hearing-related measures of psychosocial well-being, communication, and cognition. This project and training plan will provide rigorous mentored training in new methods focused on epidemiological and public health research in audiology, grantsmanship, teaching, and career/professional development, and will support the applicant’s long-term goals of being an independent, NIH-funded clinician-researcher.

项目总结/摘要 听力损失（ARHL）是一种非常普遍的慢性疾病， 社会心理健康、沟通和认知功能。使用助听器（HA）缓解 ARHL的负面影响是不确定的，部分原因是， 有足够随访时间的听证会很少，很少有人考虑早期干预的程度 联合HA可改善长期HA结局，并减少ARHL的广泛后果。很长的- 长期目标是通过最大化HA的整体效益来减少ARHL的影响。具体目标是 全面评估使用HA对心理健康、沟通和认知结果的益处， 了解一般和听力特定的健康状况，并确定ARHL早期干预的程度， HA获益的决定因素。为实现这一目标，提出了两个具体目标。目标1将使用 来自南卡罗来纳州医科大学（MUSC）ARHL纵向队列研究的纵向数据， 确定使用HA的益处，评估早期干预的贡献，并检验假设：a）使用 HA将与更好的一般健康方面的心理社会健康，认知， 沟通，和B）HA的早期干预将与更大的HA益处相关，如由以下因素确定的： 这些结果。目标2将使用跨时期数据来确定使用HA的益处并评估贡献 使用MUSC纵向队列参与者的历史和新收集的数据进行早期干预 ARHL研究旨在检验假设：a）使用HA与更好的听力特异性心理社会相关 健康和沟通结果，以及B）HA的早期干预将与更大的HA相关 这些结果决定了收益。该项目的结果将对公共卫生研究产生积极影响 和临床实践。具体而言，结果可以为未来的流行病学研究和/或临床试验提供信息， 确定早期干预对HA获益的影响，HA干预的最佳时机，以及适当的 开始筛查ARHL的年龄。该项目和研究方向直接面向美国国家科学院 科学，工程和医学（2016年）建议改善基于人口的前瞻性 关于ARHL及其治疗影响的证据，并与NIDCD关于中学和 为ARHL患者提供三级预防和健康促进。也就是说，该提案旨在确定 ARHL早期干预的重要性（二级预防）和使用HA的益处（三级预防） 关于心理健康、沟通和认知的一般和听力相关措施。这 项目和培训计划将提供严格的指导培训，重点是流行病学的新方法 听力学、听力学、教学和职业/专业发展方面的公共卫生研究，以及 将支持申请人的长期目标是一个独立的，NIH资助的临床研究人员。