Early intervention as a determinant of hearing aid benefit for age-related hearing loss: Results from longitudinal cohort studies

早期干预是助听器对年龄相关性听力损失有益的决定因素：纵向队列研究的结果

• 批准号: 10749385
• 负责人: Lauren Kay Dillard
• 金额: $ 7.61万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10749385
• 关键词: Address; Adult; Age; Aging; Apple; Audiology; Chronic; Clinical; Clinical Trials; Cognition; Cognitive; Cohort Studies; Communication; Communities; Data; Development; Diagnosis; Early Intervention; Educational process of instructing; Engineering; Environment; Epidemiology; Funding; Future; General Population; Goals; Health; Health Personnel; Health Promotion; Hearing; Hearing Aids; Individual; Intervention; Knowledge; Longitudinal cohort study; Measures; Medical; Medicine; Mentors; Methods; National Institute on Deafness and Other Communication Disorders; Neuronal Plasticity; Outcome; Participant; Population Study; Presbycusis; Public Health; Randomized, Controlled Trials; Recommendation; Research; Research Personnel; Research Project Grants; Risk; Sampling; Secondary Prevention; Severities; South Carolina; Speech; Strategic Planning; Surveys; Testing; Time; Training; United States National Academy of Sciences; United States National Institutes of Health; Universities; Work; career; clinical practice; cognitive function; dalton; epidemiology study; evidence base; follow-up; frailty; hearing impairment; help-seeking behavior; human old age (65+); improved; population based; prospective; psychosocial; psychosocial wellbeing; public health priorities; public health research; screening; tertiary prevention; uptake

PROJECT SUMMARY/ABSTRACT Age-related hearing loss (ARHL) is a highly prevalent chronic condition and is associated with poorer psychosocial well-being, communication, and cognitive function. Evidence that hearing aid (HA) use mitigates negative consequences of ARHL is inconclusive because, in part, longitudinal population-based studies of hearing with sufficient follow-up times are rare and few have considered the extent to which earlier intervention with HA improves long-term HA outcomes and reduces the wide-ranging consequences of ARHL. The long- term objective is to reduce impacts of ARHL by maximizing overall HA benefit. The specific objective is to holistically assess benefits of HA use on psychosocial well-being, communication, and cognitive outcomes that capture general and hearing-specific health and determine the extent to which earlier intervention for ARHL is a determinant of HA benefit. To achieve this objective, two specific aims are proposed. Aim 1 will use longitudinal data from the Medical University of South Carolina (MUSC) Longitudinal Cohort Study of ARHL to determine benefits of HA use and assess contributions of early intervention and test hypotheses that a) use of HA will be associated with better general health aspects of psychosocial well-being, cognition, and communication, and b) earlier intervention with HA will be associated with greater HA benefit as determined by these outcomes. Aim 2 will use cross-temporal data to determine benefits of HA use and assess contributions of early intervention using historic and newly collected data from participants in the MUSC Longitudinal Cohort Study of ARHL to test hypotheses that a) use of HA will be associated with better hearing-specific psychosocial well-being and communication outcomes, and b) earlier intervention with HA will be associated with greater HA benefit as determined by these outcomes. Results from this project will positively impact public health research and clinical practice. Specifically, results can inform future epidemiological research and/or clinical trials aiming to determine effects of early intervention on HA benefit, optimal timing of HA interventions, and the appropriate age to begin screening for ARHL. This project and line of research directly addresses the National Academies of Sciences, Engineering, and Medicine (2016) recommendation to improve prospective population-based evidence on impacts of ARHL and its treatment and aligns with NIDCD’s strategic plan on secondary and tertiary prevention and health promotion for individuals with ARHL. That is, this proposal aims to determine importance of early intervention for ARHL (secondary prevention) and benefits of HA use (tertiary prevention) on general and hearing-related measures of psychosocial well-being, communication, and cognition. This project and training plan will provide rigorous mentored training in new methods focused on epidemiological and public health research in audiology, grantsmanship, teaching, and career/professional development, and will support the applicant’s long-term goals of being an independent, NIH-funded clinician-researcher.

项目摘要/摘要 与年龄相关的听力损失（ARHL）是一种高度普遍的慢性病，​​与较差有关 社会心理健康，沟通和认知功能。助听器（HA）使用缓解的证据 ARHL的负面后果尚无定论，因为部分基于纵向人群的研究 有足够随访时间的听力很少见，很少有人认为早期干预的程度 随着HA的发展，HA的长期结果并减少了ARHL的广泛后果。长期 术语目标是通过最大化总体HA益处来减少ARHL的影响。具体目标是 整体评估HA使用对社会心理健康，沟通和认知结果的好处 捕获一般和特定于听力的健康，并确定早期对ARHL的干预程度 HA福利的确定者。为了实现这一目标，提出了两个具体目标。 AIM 1将使用 南卡罗来纳州医科大学（MUSC）ARHL纵向队列研究的纵向数据 确定HA使用和评估贡献的好处，并测试假设a） HA将与社会心理健康，认知和认知的更好的一般健康方面有关 沟通和b）早期对HA的干预将与由更大的HA益处相关联 这些结果。 AIM 2将使用跨阶段数据来确定HA使用和评估贡献的好处 使用历史和新收集的MUSC纵向队列参与者的数据进行早期干预 研究ARHL测试假设，即a）使用HA将与更好的听力特异性社会心理有关 福祉和沟通成果，b）早期与HA的干预将与更大的HA有关 这些结果确定的好处。该项目的结果将对公共卫生研究产生积极影响 和临床实践。具体而言，结果可以为未来的流行病学研究和/或临床试验提供信息。 确定早期干预对HA益处的影响，HA干预的最佳时机以及适当的 开始筛选ARHL的年龄。该项目和研究线直接解决了国家科学院 科学，工程和医学（2016）提出的建议，以改善基于人群的预期 关于ARHL及其治疗的影响的证据，并与NIDCD关于中学和中学的战略计划保持一致 ARHL患者的第三级预防和健康促进。也就是说，该建议旨在确定 早期干预对ARHL的重要性（次要预防）和HA使用的益处（第三级预防） 关于一般和听力有关的心理社会福祉，沟通和认知的衡量标准。这 项目和培训计划将提供针对流行病学的新方法的严格修复培训 以及听力学，授予技巧，教学和职业/职业发展的公共卫生研究，以及 将支持申请人成为一名独立的NIH资助临床研究者的长期目标。