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Corticofugal contributions to auditory perceptual learning

皮质对听觉感知学习的贡献

基本信息

批准号：
10749249
负责人：
Rose Ying
金额：
$ 3.75万
依托单位：
UNIV OF MARYLAND, COLLEGE PARK
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10749249
关键词：
Ablation Adult Anatomy Animal Model Animals Apoptosis Area Area Under Curve Auditory Auditory Perception Auditory area Behavior Behavioral Calcium Cells Child Clinical Communication Complex Comprehension Control Groups Cues Detection Development Devices Discrimination Electrodes Electrophysiology (science)Familiarity Fiber Geniculate body structure Human Impairment Individual Inferior Colliculus Injections Language Development Learning Maintenance Measures Medial Mediating Monitor Morphologic artifacts Movement Music Neurons Pathway interactions Patients Perceptual learning Performance Photometry Play Population Positioning Attribute Presbycusis Process Production Psychometrics Role Sensory Shapes Signal Transduction Speech Stimulus Testing Time Training Viral auditory discrimination auditory pathway auditory stimulus cell type design experimental group experimental study extracellular fluorophore hearing impairment improved in vivo neural neural circuit normal hearing presynaptic prevent response sensor sensory stimulus skills sound speech recognition vector

项目摘要

PROJECT SUMMARY Practice can improve the detection or discrimination of auditory stimuli. This process, called perceptual learning, facilitates language acquisition and the development of musical skills, and improves speech understanding in the hearing-impaired. Previous studies have highlighted the importance of the auditory cortex in auditory perceptual learning, but we lack a complete understanding of the neural circuit mechanisms involved. Corticofugal projections from the auditory cortex to subcortical auditory regions comprise a massive descending pathway. This pathway integrates non-sensory inputs, which are essential to perceptual learning, with sensory information and sharpens neural responses to relevant stimuli in subcortical auditory regions. Inactivation of this corticofugal pathway also impairs learning in sensory tasks with difficult, near-threshold stimuli. Taken together, the existing evidence suggests that corticofugal projections are well-positioned to play an important role in perceptual learning. The core hypothesis of this proposal is that perceptual training strengthens corticofugal modulation of activity in the ascending auditory pathway, leading to gradual enhancements in signal detection that underlie perceptual learning. Aim 1 will use in vivo electrophysiology in freely-moving, behaving animals to determine whether there are learning-related changes in neural activity in subcortical auditory regions. Aim 2 will investigate whether corticofugal projections are necessary for the acquisition and/or maintenance of training-induced improvements in perceptual sensitivity. Aim 3 will use projection-specific fiber photometry recordings to assess if the activity of corticofugal neurons correlates with behavioral improvements during perceptual learning. The findings from the proposed experiments will shed light on the neural circuits underlying auditory perceptual learning and may ultimately inform strategies to improve auditory perception in clinical populations.

项目总结