From Speech Function to Communicative Participation in Dysarthria

从言语功能到构音障碍的交流参与

• 批准号: 10749833
• 负责人: Abigail Haenssler
• 金额: $ 7.14万
• 依托单位: MGH INSTITUTE OF HEALTH PROFESSIONS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10749833
• 关键词: Acoustics; Address; Affect; Amyotrophic Lateral Sclerosis; Area; Cellular Phone; Characteristics; Clinical; Communication; Communication impairment; Data; Data Collection; Development; Diagnosis; Disease; Dysarthria; Frequencies; Geographic Locations; Goals; Health; Impairment; Individual; Intervention; Knowledge; Language; Linear Regressions; Link; Measures; Mediating; Mediation; Medical Research; Mission; Monitor; National Institute on Deafness and Other Communication Disorders; Neurodegenerative Disorders; Ownership; Partner Communications; Patient Self-Report; Persons; Prevalence; Production; Quality of life; Research; Signal Transduction; Social Network; Speech; Speech Acoustics; Speech Disorders; Testing; Voice; Work; clinical decision support; clinical decision-making; clinical practice; evidence base; experience; falls; impression; improved; innovation; mHealth; mobile computing; motor symptom; optimal treatments; social; therapy design; tool

PROJECT SUMMARY Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with a prevalence of over 5 cases per 100,000 people. People with ALS (PALS) typically develop bulbar motor symptoms throughout the course of the disease, often leading to dysarthria, a neuromotor disorder of speech execution. Dysarthria interferes with successful communicative interactions by reducing intelligibility, increasing the effort required by listeners to understand the speech signal, and reducing speech naturalness. Gaps in our understanding of the underlying speech production factors contributing to communicative participation are significant barriers to identifying treatment targets, identifying the onset of communicative participation restrictions, and monitoring progress. To address these gaps, a better understanding of the acoustic and perceptual attributes of dysarthria that degrade communicative participation is critical. The purpose of this project is to identify causal links between speech acoustic features, perceptual speech features, and communicative participation. In Aim 1, we test the hypothesis that listener effort and speech naturalness will be strongly associated with communicative participation using bivariate correlations and multiple linear regression. In Aim 2, we test the hypotheses that (1) acoustic features related to speech clarity will be strongly associated with listener effort, and (2) that acoustic features representing prosody will be strongly associated with speech naturalness, using bivariate correlations and multiple linear regression. In Aim 3, we test the hypothesis that speech acoustics will predict communicative participation and that this relationship will be primarily mediated through clinical impressions of listener effort and speech naturalness using a mediation analysis. The long-term goal of the proposed research is to maximize communicative participation, and thereby improve the quality of life of PALS. Results will inform treatment by (1) guiding the use of evidence-based clinical tools (e.g., listener effort and naturalness rating scales) that are associated with communicative participation for assessment and monitoring, and (2) identifying specific treatment (e.g., articulatory precision, speech prosody) targets to support communicative participation. This project falls under NIDCD’s Priority Area 3 in Voice, Speech, and Language Research, as it investigates a causal framework that could support diagnosis, treatment, and progress monitoring in individuals with speech impairments. Furthermore, this work is in line with NIDCD’s mission to further our knowledge and understanding of communication disorders.

项目概要 肌萎缩侧索硬化症 (ALS) 是一种毁灭性的神经退行性疾病，患病率超过 5 每 10 万人中的病例数。 ALS (PALS) 患者通常会在整个过程中出现延髓运动症状 病程通常会导致构音障碍，这是一种言语执行的神经运动障碍。构音障碍 通过降低可理解性、增加沟通所需的努力来干扰成功的沟通互动 听者理解语音信号，并降低语音自然度。我们的理解存在差距 有助于交际参与的潜在言语产生因素是显着障碍 确定治疗目标、确定交流参与限制的发生以及监测 进步。为了解决这些差距，更好地理解构音障碍的声学和感知属性 降低沟通参与度至关重要。该项目的目的是确定因果关系 语音声学特征、感知语音特征和交际参与之间的关系。在目标 1 中，我们 检验以下假设：听众的努力和言语自然度与交际能力密切相关 使用二元相关性和多元线性回归进行参与。在目标 2 中，我们测试以下假设： (1) 与语音清晰度相关的声学特征与听者的努力密切相关，并且 (2) 使用双变量表示韵律的声学特征将与语音自然度密切相关 相关性和多元线性回归。在目标 3 中，我们测试语音声学将预测的假设 交流参与，并且这种关系将主要通过临床印象来调节 使用中介分析的听众努力和言语自然度。拟议研究的长期目标 是最大化沟通参与，从而提高 PALS 的生活质量。结果将告知 通过 (1) 指导使用基于证据的临床工具（例如，听者的努力和自然度评级）进行治疗 量表）与评估和监测的交流参与相关，以及（2）确定 具体治疗（例如发音精确度、言语韵律）目标是支持交流参与。 该项目属于 NIDCD 的语音、言语和语言研究优先领域 3，因为它调查了 可以支持有言语的个体的诊断、治疗和进展监测的因果框架 损伤。此外，这项工作符合 NIDCD 的使命，即增进我们的知识和 对沟通障碍的理解。