Neural and Behavioral Indices of Balance Performance in Individuals with sensory loss

感觉丧失个体平衡表现的神经和行为指数

• 批准号: 10751174
• 负责人: Brittani A Morris
• 金额: $ 4.13万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10751174
• 关键词: Activities of Daily Living; Adult; Affect; Age; Anatomy; Attention; Auditory; Auditory system; Behavior; Behavior assessment; Behavioral; Brain; Clinical; Cognitive; Compensation; Complex; Conscious; Cues; Data; Data Set; Dependence; Development; Disease; Dizziness; Dorsal; Environment; Equilibrium; Evaluation; Exhibits; Eye; Functional Magnetic Resonance Imaging; Future; Gait; Goals; Health; Individual; Intervention; Knowledge; Literature; Measures; Mission; Motor; Movement; National Institute on Deafness and Other Communication Disorders; Network-based; Neurobiology; Participant; Pathway Analysis; Patients; Performance; Peripheral; Persons; Positioning Attribute; Postdoctoral Fellow; Posture; Public Health; Research; Resources; Rest; Sensorineural Hearing Loss; Sensory; Testing; United States; Vestibular loss; Vision; Visual; Visual attention; Work; analysis pipeline; balance testing; behavior measurement; equilibration disorder; fall risk; falls; follow-up; hearing impairment; improved; indexing; inner ear diseases; medical attention; motor control; neural; neural patterning; neuroimaging; normal hearing; sensory input; virtual reality environment; visual stimulus

ABSTRACT People with unilateral vestibular hypofunction (VH, peripheral disease of the inner ear) are thought to develop visual dependence. They get dizzy and off balance in complex visual environments. They sway more with dynamic visuals compared to static or with eyes closed compared to open. Individuals with UHL are not regularly assessed for balance function, but those with at least moderate hearing loss show increased risk for falls. Data from mechanistic studies in our lab have demonstrated that individuals with UHL do not increase postural sway in the presence of complex visual scenes as much as healthy controls, suggesting they are not as reliant on visual input to maintain their balance. Based on these findings, we hypothesize that individuals with UHL may reallocate attentional resources to motor control of balance (conscious movement processing) to compensate for the loss of auditory cues. To test the hypotheses of visual dependence in VH and conscious movement processing in UHL, this proposal will combine behavioral assessments of balance with analyses of network-based functional connectivity from resting-state functional magnetic resonance imaging (fMRI). The long-term goal of this research is to identify the neurobiological index explaining balance behavior and develop an intervention approach targeting functional connectivity differences that maximizes functional mobility gains in people with sensory loss. In the current project we will address the following Specific Aims: Aim 1: Identify balance profiles for people with VH and UHL. Individuals with VH, UHL and controls (N=24 each) will perform a battery of balance measures including static, dynamic, gait, and tests targeting sensory and cognitive aspects of balance. We will also analyze their postural sway from force plate data as they are tested in a virtual reality environment. Aim 2: Identify internetwork functional connectivity differences in VH, UHL, and healthy controls. Resting-state fMRI data will be acquired from VH and UHL (N=12 each) and compared to a distribution of healthy control data. Aim 3: Determine the extent to which balance performance (Aim 1) correlate with neurobiological data (Aim 2) in VH and UHL. We will calculate correlations between postural sway data and ratio of attention-motor connectivity to attention-vision connectivity. If we accomplish our aims, we will identify which balance domains are most affected by vestibular and hearing loss and whether people with UHL should be regularly screened for balance performance. We will establish which brain connections are altered by sensory loss and the implications for balance. This knowledge will have important implications to public health for improved assessment of balance and development of future interventions in VH and UHL.

抽象的 单侧前庭功能不全（VH，内耳周围疾病）的人是 想到发展视觉依赖性。他们在复杂的视觉上变得头晕和平衡 环境。与静态或闭上眼睛相比，它们具有动态视觉效果更多的动态视觉效果 与开放相比。 UHL患有余额功能的人不经常评估 至少有听力损失显示跌倒的风险增加。来自机械研究的数据 在我们的实验室中，有UHL的人不会增加姿势的影响 存在复杂的视觉场景和健康对照一样，表明它们并不那么依赖 在视觉输入中保持平衡。基于这些发现，我们假设个人 使用UHL可以将注意力资源重新分配到平衡的运动控制（有意识的运动） 处理）以补偿听觉提示的损失。测试视觉的假设 VH的依赖性和在UHL中有意识的运动处理，该建议将结合 通过分析基于网络的功能连接的行为评估 静止状态功能磁共振成像（fMRI）。这项研究的长期目标 是确定神经生物学指数来解释平衡行为并发展干预措施 靶向功能连接性差异的方法可最大化功能迁移率 感官损失的人。在当前项目中，我们将解决以下特定目标：目标 1：确定VH和UHL患者的平衡概况。患有VH，UHL和对照的人 （n = 24）将执行一系列平衡措施，包括静态，动态，步态和测试 定位平衡的感觉和认知方面。我们还将分析他们的姿势摇摆 在虚拟现实环境中对其进行测试的强制板数据。目标2：确定互联网工作 VH，UHL和健康对照中的功能连通性差异。静止状态fMRI数据将 可从VH和UHL（每个= 12）获取，并与健康对照数据的分布进行比较。 目标3：确定平衡性能（目标1）与神经生物学相关的程度 VH和UHL中的数据（AIM 2）。我们将计算姿势摇摆数据与比率之间的相关性 注意力机连通性与注意事件连通性的连通性。 如果我们实现目标，我们将确定哪些平衡领域受到最大影响 前庭和听力损失以及是否应定期筛选患有UHL的人 平衡表现。我们将通过感官丧失和 对平衡的影响。这些知识将对公共卫生具有重要意义 改进了VH和UHL未来干预措施的平衡和发展的评估。