HBCD Study Biospecimens Administrative Supplement: Resource Generation for Delivery Specimens
六溴环十二烷研究生物样本行政补充:交付样本的资源生成
基本信息
- 批准号:10750480
- 负责人:
- 金额:$ 17.54万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-30 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:Administrative SupplementAdmission activityAlcoholsAnxietyBehaviorBehavioralBiologicalBiologyBrainCannabisCaregiversChildChild DevelopmentChild HealthChildhoodClinical ResearchCognitionCognitiveCollectionCommunitiesComplexCongenital AbnormalityCore FacilityData CollectionDetectionDevelopmentDiscipline of obstetricsEducationEmergency MedicineEpigenetic ProcessEquipmentEtiologyEvaluationExposure toFamilyFetal GrowthFetal ReductionFetusFundingFutureGenerationsGeneticGoalsGynecologyHealthHealthcareHeavy MetalsHelping to End Addiction Long-termHospitalsImmuneIndividualInfant DevelopmentInfant HealthInfrastructureKnowledgeLaboratoriesLanguage DelaysLanguage DevelopmentLinkLongitudinal StudiesLow Birth Weight InfantMaternal HealthMediatingMedical centerMemory impairmentMetabolicMonitorNational Institute of Drug AbuseNeonatal Abstinence SyndromeOpioidOutcomeParentsParticipantPathogenicityPlacentaPoliciesPredispositionPregnancyPregnant WomenPremature BirthPrenatal carePreventionPrevention strategyProcessProteinsProtocols documentationPsychopathologyResearchResearch AssistantResourcesRiskSamplingScienceServicesSignaling ProteinSiteSpecimenTissue BanksTissuesTobaccoTraumaUmbilical Cord BloodUmbilical cord structureUnited StatesUniversitiesVermontadverse outcomealcohol consumption during pregnancyelectronic medical record systememotion regulationfetalfetal opioid exposurefetal substance exposurein uteroinattentioninnovationinterestlongitudinal, prospective studymRNA Expressionmaternal opioid usememberneonatal healthneurodevelopmentneuroimagingnutritionopioid useopioid use disorderopioid use in pregnancypolysubstance usepregnantprenatalprenatal exposureprogramsprotocol developmentracismresponsesocialsubstance usesuccesstoxicant
项目摘要
PROJECT SUMMARY
Opioid use during pregnancy is widespread and associated with adverse outcomes for the pregnant individual
and the developing child. Prenatal opioid exposure is associated with a wide range of negative fetal and child
outcomes including reduced fetal growth, premature birth, lower birth weight, congenital defects, increased
neonatal healthcare, and heightened risk for later behavioral (e.g., anxiety, inattention), cognitive (e.g., memory
deficits, delayed language acquisition), and metabolic problems. Despite opioid use being linked to adverse
maternal, fetal, and child outcomes, the mechanisms through which these arise and the potential consequences
of prenatal opioid exposure for child health and development (e.g., brain and behavior) remain largely
unexplored. This lack of etiologic knowledge has contributed to stagnant treatment, prevention, and mitigation
efforts leaving individuals and families susceptible to reverberating adverse outcomes.
The HEALthy Brain and Child Development (HBCD) Study is a 25-site longitudinal prospective study of
early child development in the US that will assess a broad spectrum of biological (e.g., neuroimaging, genetics,
epigenetics), behavioral (e.g., cognition and emotional regulation), experiential (e.g., trauma), social (e.g.,
racism), and health (e.g., psychopathology) factors among ~7,500 nationally-representative pregnant women
and their children from pregnancy to mid-childhood. A major goal of the HBCD study is to increase understanding
of the potential consequences of prenatal substance exposures. It will be enriched for maternal substance use
during pregnancy (i.e., ~25% of the sample will be using opioids, cannabis, alcohol, and/or tobacco during
pregnancy and 12% of the total sample will be using opioids) and offers a unique opportunity to inform our
understanding of how the adverse consequences associated with opioid use during pregnancy arise. Although
HBCD will be the largest long-term study of early brain and child development outcomes in the US, the core
protocol does not include the collection of delivery biospecimens. This Administrative Supplement in response
to the NIDA/ORWH Administrative Supplement Notice of Special Interests: HEAL Initiative: Biospecimen
Collection in Pregnancy (NOT-DA-23-005) proposes to leverage the HEALthy Brain and Child Development
(HBCD) by expanding the biospecimen collection of the Core HBCD Protocol to include delivery specimens
(placenta, cord tissue, cord blood). Delivery samples will be collected from a representative sample of HBCD
Study participants across up to 14 sites (and over 2,000 participants across HBCD sites submitting applications
in response to this NOSI). This will provide an unprecedented resource generating opportunity for a larger
scientific community to comprehensively evaluate pathophysiological mechanisms that mediate the connection
between opioid and polysubstance use during pregnancy and adverse neonatal, infant, and/or maternal health
outcomes and, in turn, inform innovative preventive strategies.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('HUGH P. GARAVAN', 18)}}的其他基金
Scientific Training in Addiction Research Techniques (START) for gifted future investigators from historically underrepresented and underserved backgrounds.
成瘾研究技术科学培训 (START),面向来自历史上代表性不足和服务不足的背景的有天赋的未来研究人员。
- 批准号:
10741281 - 财政年份:2023
- 资助金额:
$ 17.54万 - 项目类别:
20/24 The Healthy Brain and Child Development National Consortium
20/24 健康大脑和儿童发展国家联盟
- 批准号:
10379601 - 财政年份:2021
- 资助金额:
$ 17.54万 - 项目类别:
Scientific training in addiction research techniques (START) for gifted future investigators from historically underrepresented and underserved backgrounds
为来自历史上代表性不足和服务不足的背景的有天赋的未来研究人员提供成瘾研究技术的科学培训(START)
- 批准号:
10441743 - 财政年份:2021
- 资助金额:
$ 17.54万 - 项目类别:
20/24 The Healthy Brain and Child Development National Consortium
20/24 健康大脑和儿童发展国家联盟
- 批准号:
10494215 - 财政年份:2021
- 资助金额:
$ 17.54万 - 项目类别:
20/24 The Healthy Brain and Child Development National Consortium
20/24 健康大脑和儿童发展国家联盟
- 批准号:
10661747 - 财政年份:2021
- 资助金额:
$ 17.54万 - 项目类别:
19/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UVM
19/21 ABCD-美国联盟:UVM 研究项目现场
- 批准号:
9982479 - 财政年份:2020
- 资助金额:
$ 17.54万 - 项目类别:
19/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UVM
19/21 ABCD-美国联盟:UVM 研究项目现场
- 批准号:
10385855 - 财政年份:2020
- 资助金额:
$ 17.54万 - 项目类别:
19/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UVM
19/21 ABCD-美国联盟:UVM 研究项目现场
- 批准号:
10594436 - 财政年份:2020
- 资助金额:
$ 17.54万 - 项目类别:
3 of 4, Investigation of opioid exposure and neurodevelopment (iOPEN)
3 of 4,阿片类药物暴露和神经发育的调查 (iOPEN)
- 批准号:
9900443 - 财政年份:2019
- 资助金额:
$ 17.54万 - 项目类别:
3 of 4, Investigation of opioid exposure and neurodevelopment (iOPEN)
3 of 4,阿片类药物暴露和神经发育的调查 (iOPEN)
- 批准号:
10020453 - 财政年份:2019
- 资助金额:
$ 17.54万 - 项目类别: