HBCD Study Biospecimens Administrative Supplement: Resource Generation for Delivery Specimens

六溴环十二烷研究生物样本行政补充:交付样本的资源生成

基本信息

项目摘要

PROJECT SUMMARY Opioid use during pregnancy is widespread and associated with adverse outcomes for the pregnant individual and the developing child. Prenatal opioid exposure is associated with a wide range of negative fetal and child outcomes including reduced fetal growth, premature birth, lower birth weight, congenital defects, increased neonatal healthcare, and heightened risk for later behavioral (e.g., anxiety, inattention), cognitive (e.g., memory deficits, delayed language acquisition), and metabolic problems. Despite opioid use being linked to adverse maternal, fetal, and child outcomes, the mechanisms through which these arise and the potential consequences of prenatal opioid exposure for child health and development (e.g., brain and behavior) remain largely unexplored. This lack of etiologic knowledge has contributed to stagnant treatment, prevention, and mitigation efforts leaving individuals and families susceptible to reverberating adverse outcomes. The HEALthy Brain and Child Development (HBCD) Study is a 25-site longitudinal prospective study of early child development in the US that will assess a broad spectrum of biological (e.g., neuroimaging, genetics, epigenetics), behavioral (e.g., cognition and emotional regulation), experiential (e.g., trauma), social (e.g., racism), and health (e.g., psychopathology) factors among ~7,500 nationally-representative pregnant women and their children from pregnancy to mid-childhood. A major goal of the HBCD study is to increase understanding of the potential consequences of prenatal substance exposures. It will be enriched for maternal substance use during pregnancy (i.e., ~25% of the sample will be using opioids, cannabis, alcohol, and/or tobacco during pregnancy and 12% of the total sample will be using opioids) and offers a unique opportunity to inform our understanding of how the adverse consequences associated with opioid use during pregnancy arise. Although HBCD will be the largest long-term study of early brain and child development outcomes in the US, the core protocol does not include the collection of delivery biospecimens. This Administrative Supplement in response to the NIDA/ORWH Administrative Supplement Notice of Special Interests: HEAL Initiative: Biospecimen Collection in Pregnancy (NOT-DA-23-005) proposes to leverage the HEALthy Brain and Child Development (HBCD) by expanding the biospecimen collection of the Core HBCD Protocol to include delivery specimens (placenta, cord tissue, cord blood). Delivery samples will be collected from a representative sample of HBCD Study participants across up to 14 sites (and over 2,000 participants across HBCD sites submitting applications in response to this NOSI). This will provide an unprecedented resource generating opportunity for a larger scientific community to comprehensively evaluate pathophysiological mechanisms that mediate the connection between opioid and polysubstance use during pregnancy and adverse neonatal, infant, and/or maternal health outcomes and, in turn, inform innovative preventive strategies.
项目总结

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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HUGH P. GARAVAN其他文献

HUGH P. GARAVAN的其他文献

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{{ truncateString('HUGH P. GARAVAN', 18)}}的其他基金

Scientific Training in Addiction Research Techniques (START) for gifted future investigators from historically underrepresented and underserved backgrounds.
成瘾研究技术科学培训 (START),面向来自历史上代表性不足和服务不足的背景的有天赋的未来研究人员。
  • 批准号:
    10741281
  • 财政年份:
    2023
  • 资助金额:
    $ 17.54万
  • 项目类别:
20/24 The Healthy Brain and Child Development National Consortium
20/24 健康大脑和儿童发展国家联盟
  • 批准号:
    10379601
  • 财政年份:
    2021
  • 资助金额:
    $ 17.54万
  • 项目类别:
Scientific training in addiction research techniques (START) for gifted future investigators from historically underrepresented and underserved backgrounds
为来自历史上代表性不足和服务不足的背景的有天赋的未来研究人员提供成瘾研究技术的科学培训(START)
  • 批准号:
    10441743
  • 财政年份:
    2021
  • 资助金额:
    $ 17.54万
  • 项目类别:
20/24 The Healthy Brain and Child Development National Consortium
20/24 健康大脑和儿童发展国家联盟
  • 批准号:
    10494215
  • 财政年份:
    2021
  • 资助金额:
    $ 17.54万
  • 项目类别:
20/24 The Healthy Brain and Child Development National Consortium
20/24 健康大脑和儿童发展国家联盟
  • 批准号:
    10661747
  • 财政年份:
    2021
  • 资助金额:
    $ 17.54万
  • 项目类别:
19/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UVM
19/21 ABCD-美国联盟:UVM 研究项目现场
  • 批准号:
    9982479
  • 财政年份:
    2020
  • 资助金额:
    $ 17.54万
  • 项目类别:
19/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UVM
19/21 ABCD-美国联盟:UVM 研究项目现场
  • 批准号:
    10385855
  • 财政年份:
    2020
  • 资助金额:
    $ 17.54万
  • 项目类别:
19/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UVM
19/21 ABCD-美国联盟:UVM 研究项目现场
  • 批准号:
    10594436
  • 财政年份:
    2020
  • 资助金额:
    $ 17.54万
  • 项目类别:
3 of 4, Investigation of opioid exposure and neurodevelopment (iOPEN)
3 of 4,阿片类药物暴露和神经发育的调查 (iOPEN)
  • 批准号:
    9900443
  • 财政年份:
    2019
  • 资助金额:
    $ 17.54万
  • 项目类别:
3 of 4, Investigation of opioid exposure and neurodevelopment (iOPEN)
3 of 4,阿片类药物暴露和神经发育的调查 (iOPEN)
  • 批准号:
    10020453
  • 财政年份:
    2019
  • 资助金额:
    $ 17.54万
  • 项目类别:
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