Mentoring Across Disciplines: Aging and Infectious Diseases with a Focus on Mobility

跨学科指导：以流动性为重点的老龄化和传染病

• 批准号: 10757167
• 负责人: Kristine Mace Erlandson
• 金额: $ 19.19万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10757167
• 关键词: Acceleration; Address; Adherence; Adult; Age; Aging; Award; Behavioral; Biological; Cardiovascular system; Clinic; Clinical; Clinical Management; Clinical Trials; Communicable Diseases; Communities; Data; Development Plans; Discipline; Dissemination and Implementation; Effectiveness of Interventions; Elderly; Elements; Ensure; Epidemiology; Evaluation; Exercise; Feedback; Funding; Future; Geriatric Assessment; Geriatrics; Goals; Group Interviews; Guidelines; HIV; Health; Impairment; Income; Individual; Institution; Interval training; Intervention; Interview; Knowledge; Leadership; Location; Lower Extremity; Measurement; Measures; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Minority Groups; Modality; Modeling; Modification; Muscle; National Institute on Aging; Outcome; Outcome Assessment; Parents; Participant; Patients; Persons; Physical Function; Physical activity; Positioning Attribute; Poverty; Process; Provider; Randomized; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Research; Research Personnel; Risk; Role; Scanning; Science; Structure; Surveys; Text Messaging; Thick; Time; Training; Upper Extremity; Work; acceptability and feasibility; aged; career; career development; clinical care; community based research; design; effective intervention; evidence base; exercise intensity; exercise intervention; exercise prescription; experience; functional decline; health data; health disparity; health equity; healthy aging; implementation research; improved; informant; member; motivational enhancement therapy; muscle form; patient oriented; patient oriented research; portability; pragmatic implementation; preference; preservation; prevent; programs; resistance exercise; social culture; systematic review; tool; ultrasound; uptake

PROJECT SUMMARY This K24 Mid-Career Mentoring Award supports my further career development and 50% protected time for mentoring and research. My patient-oriented research has bridged the intersection between HIV and geriatric medicine, through which I have developed a research program to describe the epidemiology and underlying mechanisms of HIV and aging, and introduced interventions focused on the successful aging of people with HIV (and other infectious diseases). Through the K24 award, I propose to take my research from the bench and the bedside into the clinic and community by gaining training in dissemination/implementation and community-based research principles (Training Aim 1) and health equity and inclusion in research, mentorship, and leadership (Training Aim 2). To provide hands-on training for these career development aims, I will focus on improving methods for measurement of muscle mass and quality in physical activity interventions (Aim 1). In Aim 2, I will work to improve methods for pragmatic and feasible interventions through a systematic review of existing interventions, input from key informants, and an environmental scan, with a focus on what is feasible and acceptable. We will conduct a systematic review and individual or group interviews, and used mixed methods to incorporate these findings with data from the parent R01, HEALTH. Lastly, I will use knowledge from Aims 1 and 2 to enhance existing physical activity programs for greater dissemination and implementation (Aim 3). I will be supported by mentors with expertise in dissemination/ implementation and health equity, in addition to three ongoing mentors with cross-disciplinary research programs, outstanding mentorship accolades, and leadership positions within their institutions. Lastly, my institution has provided me with the additional support, most critically in time protected from additional clinical or administrative duties. In summary, the proposed K24 will leverage my current R01 to serve as a training platform for trainees and incorporate my career development objectives, ultimately advancing the science of interventions to preserve physical function in older people with HIV and support patient-oriented researchers.

项目概要 这个 K24 职业生涯中期指导奖支持我进一步的职业发展，并为我提供 50% 的受保护时间 指导和研究。我以患者为中心的研究弥合了艾滋病毒和老年病之间的交叉点 医学，通过它我制定了一个研究计划来描述流行病学和潜在的 艾滋病毒和老龄化的机制，并引入了重点关注艾滋病毒和老龄化人群成功老龄化的干预措施 艾滋病毒（和其他传染病）。通过 K24 奖，我建议从实验室开始我的研究 通过获得传播/实施和 基于社区的研究原则（培训目标 1）以及健康公平和研究包容性， 指导和领导力（培训目标 2）。为这些职业发展提供实践培训 目标，我将专注于改进身体活动中肌肉质量和质量的测量方法 干预（目标 1）。在目标 2 中，我将努力通过以下方式改进务实可行的干预措施的方法： 对现有干预措施、主要知情者的意见和环境扫描进行系统审查， 关注可行和可接受的事情。我们将对个人或团体进行系统审查 访谈，并使用混合方法将这些发现与母公司 R01 HEALTH 的数据结合起来。 最后，我将利用目标 1 和 2 中的知识来加强现有的身体活动计划，以实现更大的目标 传播和实施（目标 3）。我将得到具有传播/传播专业知识的导师的支持 实施和健康公平，以及三名正在进行跨学科研究的导师 计划、杰出的指导荣誉以及机构内的领导职位。最后，我的 机构为我提供了额外的支持，最重要的是及时保护我免受额外的临床 或行政职责。综上所述，拟议的K24将利用我当前的R01作为培训 为学员提供平台并纳入我的职业发展目标，最终推进科学 保护老年艾滋病毒感染者的身体功能并支持以患者为中心的研究人员的干预措施。