Mentoring Across Disciplines: Aging and Infectious Diseases with a Focus on Mobility

跨学科指导：以流动性为重点的老龄化和传染病

• 批准号: 10757167
• 负责人: Kristine Mace Erlandson
• 金额: $ 19.19万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10757167
• 关键词: Acceleration; Address; Adherence; Adult; Age; Aging; Award; Behavioral; Biological; Cardiovascular system; Clinic; Clinical; Clinical Management; Clinical Trials; Communicable Diseases; Communities; Data; Development Plans; Discipline; Dissemination and Implementation; Effectiveness of Interventions; Elderly; Elements; Ensure; Epidemiology; Evaluation; Exercise; Feedback; Funding; Future; Geriatric Assessment; Geriatrics; Goals; Group Interviews; Guidelines; HIV; Health; Impairment; Income; Individual; Institution; Interval training; Intervention; Interview; Knowledge; Leadership; Location; Lower Extremity; Measurement; Measures; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Minority Groups; Modality; Modeling; Modification; Muscle; National Institute on Aging; Outcome; Outcome Assessment; Parents; Participant; Patients; Persons; Physical Function; Physical activity; Positioning Attribute; Poverty; Process; Provider; Randomized; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Research; Research Personnel; Risk; Role; Scanning; Science; Structure; Surveys; Text Messaging; Thick; Time; Training; Upper Extremity; Work; acceptability and feasibility; aged; career; career development; clinical care; community based research; design; effective intervention; evidence base; exercise intensity; exercise intervention; exercise prescription; experience; functional decline; health data; health disparity; health equity; healthy aging; implementation research; improved; informant; member; motivational enhancement therapy; muscle form; patient oriented; patient oriented research; portability; pragmatic implementation; preference; preservation; prevent; programs; resistance exercise; social culture; systematic review; tool; ultrasound; uptake

PROJECT SUMMARY This K24 Mid-Career Mentoring Award supports my further career development and 50% protected time for mentoring and research. My patient-oriented research has bridged the intersection between HIV and geriatric medicine, through which I have developed a research program to describe the epidemiology and underlying mechanisms of HIV and aging, and introduced interventions focused on the successful aging of people with HIV (and other infectious diseases). Through the K24 award, I propose to take my research from the bench and the bedside into the clinic and community by gaining training in dissemination/implementation and community-based research principles (Training Aim 1) and health equity and inclusion in research, mentorship, and leadership (Training Aim 2). To provide hands-on training for these career development aims, I will focus on improving methods for measurement of muscle mass and quality in physical activity interventions (Aim 1). In Aim 2, I will work to improve methods for pragmatic and feasible interventions through a systematic review of existing interventions, input from key informants, and an environmental scan, with a focus on what is feasible and acceptable. We will conduct a systematic review and individual or group interviews, and used mixed methods to incorporate these findings with data from the parent R01, HEALTH. Lastly, I will use knowledge from Aims 1 and 2 to enhance existing physical activity programs for greater dissemination and implementation (Aim 3). I will be supported by mentors with expertise in dissemination/ implementation and health equity, in addition to three ongoing mentors with cross-disciplinary research programs, outstanding mentorship accolades, and leadership positions within their institutions. Lastly, my institution has provided me with the additional support, most critically in time protected from additional clinical or administrative duties. In summary, the proposed K24 will leverage my current R01 to serve as a training platform for trainees and incorporate my career development objectives, ultimately advancing the science of interventions to preserve physical function in older people with HIV and support patient-oriented researchers.

项目总结 这项K24职业中期导师奖支持我进一步的职业发展和50%的保护时间 指导和研究。我的以病人为中心的研究在艾滋病毒和老年病之间架起了一座桥梁 医学，通过它我制定了一个研究计划来描述流行病学和潜在的 艾滋病毒和老龄化的机制，并介绍了以成功老龄化为重点的干预措施 艾滋病毒(和其他传染病)。通过K24奖，我建议从替补席上开始我的研究 并通过接受传播/实施和培训，向诊所和社区提供服务 以社区为基础的研究原则(培训目标1)和健康公平和纳入研究， 导师和领导力(培训目标2)。为这些职业发展提供实践培训 目标，我将集中在改进在体力活动中测量肌肉质量和质量的方法 干预措施(目标1)。在目标2中，我将努力改进务实和可行的干预措施的方法，方法是 对现有干预措施、关键线人的投入进行系统审查，并对环境进行扫描 把重点放在可行和可以接受的事情上。我们将对个人或团体进行系统的审查 访谈，并使用混合方法将这些发现与父母R01，健康的数据结合在一起。 最后，我将利用目标1和目标2中的知识来加强现有的体育锻炼计划，以实现更大的成就 传播和实施(目标3)。我将得到在传播方面有专长的导师的支持/ 实施和健康公平，此外还有三名从事跨学科研究的持续导师 项目，杰出的导师荣誉，以及在其机构内的领导地位。最后，我的 机构为我提供了额外的支持，最关键的是及时保护我免受额外的临床 或行政职责。总而言之，建议的K24将利用我目前的R01作为培训 为学员提供平台，并纳入我的职业发展目标，最终推动 为保护老年艾滋病毒携带者的身体功能和支持以患者为导向的研究人员而进行的干预。