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The High-Intensity Exercise to Attenuate Limitations and Train Habits (HEALTH) in Older Adults with HIV

高强度运动可减轻老年艾滋病毒感染者的限制并培养习惯（健康）

基本信息

批准号：
10599343
负责人：
Kristine Mace Erlandson
金额：
$ 78.38万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10599343
关键词：
Accelerometer Address Adherence Aerobic Aerobic Exercise Age Aging Attenuated Behavior Behavioral Bioenergetics Body fat Caring Chronic Disease Clinical Clinical Trials Colorado Coronary Arteriosclerosis Data Development Diabetes Mellitus Elderly Electron Transport Epidemic Exercise Fatigue Geriatrics Goals HIV Habits Health Healthy People 2020 Heart Rate High Prevalence Impairment Interval training Intervention Interview Knowledge Life Life Expectancy Maintenance Maximum Heart Rate Methods Mitochondria Moderate Exercise Morbidity - disease rate Outcome Participant Patients Perception Performance Peripheral Blood Mononuclear Cell Persons Pharmaceutical Preparations Physical Function Physical activity Population Quality of life Randomized Recommendation Reporting Resistance Resources Respiration Sample Size Self Direction Site Skeletal Muscle Specific qualifier value Symptoms Testing Time Training United States National Institutes of Health Universities Vulnerable Populations Walking Woman aged analytical method antiretroviral therapy arm biobehavior common symptom comorbidity daily functioning demographics design early experience exercise adherence exercise intensity exercise intervention exercise program exercise regimen experience healthspan improved innovation lifestyle factors mortality muscle form preservation reduce symptoms resistance exercise response tailored text messaging trial comparing

项目摘要

PROJECT ABSTRACT With advances in treatment and care,a longer life expectancy is changing the demographics of the HIV epidemic, and nearly half of those living with HIV in the U.S. are now 50 years or older. People living with HIV, even while receiving effective HIV medications, have excess morbidity and mortality compared to HIV- uninfected populations. Increasing age, comorbid burden, and lifestyle factors, contribute to greater than expected impairments in key components of daily function and a high burden of fatigue among older adults living with HIV. Effective, scalable, non-pharmacological strategies are needed to improve the healthspan of this vulnerable population. The overall goals of this proposal are to determine whether high-intensity interval training (HIIT) can overcome 1) physical function impairments and increased fatigue and 2) impairments in mitochondrial bioenergetics of older people with HIV (PWH) to a greater extent than continuous moderate-intensity exercise (CME). We further seek to determine whether a biobehavioral coaching intervention following either HIIT or CME can promote long-term adherence to physical activity, a crucial component of the sustainability of the intervention. We have previously demonstrated greater than expected impairments in physical function and a high prevalence of fatigue among older adults with HIV. We found that CME and resistance exercise improves physical function in older PWH, with additional improvements from a higher-intensity aerobic and resistance exercise program. Additionally, only our higher-intensity continuous aerobic exercise intervention reduced fatigue among PWH. Lastly, less than half of our participants continued to exercise at least once a week following the supervised intervention, which suggests that even when exercise is beneficial it can be difficult for PWH to maintain. Together, our findings suggest that an innovative approach to exercise is needed to improve physical function, reduce fatigue, and to maintain a long-term exercise habit among older PWH. To address this critical need, our proposed study will leverage the resources of two diverse participant populations at the University of Colorado and Case Western Reserve University to 1) Compare HIIT vs CME on physical function and fatigue, 2) Compare HIIT vs CME on skeletal muscle and peripheral blood mononuclear cell mitochondrial bioenergetics, and 3) Test a coaching intervention vs control on physical activity adherence, assessing perceptions of these approaches using mixed methods. This study will generate rigorous data on physical function and fatigue responses to exercise, the associated mitochondrial adaptations, and investigate strategies to instill sustained, self-directed exercise behavior. Overall, our findings will inform the development of scalable, effective exercise recommendations tailored to the unique needs of aging PWH.

项目摘要