Advancing Assessment of Episodic Disability to Enhance Healthy Aging among Adults with HIV: Developing a Short-Form HIV Disability Questionnaire (HDQ) for use in Clinical Practice

推进偶发性残疾评估，以促进艾滋病毒感染者的健康老龄化：制定用于临床实践的简短艾滋病毒残疾问卷 (HDQ)

• 批准号: 10002166
• 负责人: Kristine Mace Erlandson
• 金额: $ 17.16万
• 依托单位: UNIVERSITY OF TORONTO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10002166
• 关键词: Adult; Advisory Committees; Age; Aging; Canada; Caring; Clinic; Clinic Visits; Clinical; Clinical Management; Collaborations; Colorado; Communities; Consequences of HIV; Consultations; Data; Databases; Disability Evaluation; Effectiveness of Interventions; Elderly; Evaluation; Face; Female; Foundations; Future; Goals; HIV; Health; Health Personnel; Health Status; Health system; Individual; International; Intervention; Interview; Ireland; Measurement; Measures; Nature; Outcome; Participant; Patient Outcomes Assessments; Phase; Pilot Projects; Prevalence; Property; Psyche structure; Psychometrics; Questionnaires; Recommendation; Research; Resource Allocation; Services; Severities; Site; Standardization; Structure; Tablets; Testing; Time; Uncertainty; United States; Validation; Validity and Reliability; Woman; Work; age group; clinical practice; clinical research site; design; disability; experience; healthy aging; instrument; multiple chronic conditions; patient-clinician communication; phase 1 study; practice setting; rehabilitation research; social; social inclusion; trend; uptake

ABSTRACT The purpose of the proposed study is to develop and pilot the implementation of a short-form HIV-specific disability questionnaire to promote healthy aging among adults aging with HIV. Specific aims are: 1) To develop and assess the utility of a new short-form HIV-specific disability questionnaire across multiple clinical practice settings with older adults with HIV, and 2) To pilot the implementation of the new short-form HIV-specific disability questionnaire, and assess its measurement properties while collecting foundational data on the presence, severity and episodic nature of disability among adults aging with HIV and multimorbidity in the United States, Canada and Ireland. Standardized patient reported outcomes (PROs) designed to capture the nature and extent of disability and its fluctuation over time are critical to guide the provision of timely and appropriate care for adults aging with HIV. In an earlier phase of work, we developed a 69-item Patient Reported Outcome (PRO), called the HIV Disability Questionnaire (HDQ) and demonstrated its reliability and validity among adults living with HIV in Canada and Ireland. As an increasing number of adults age with HIV and multimorbidity, there is a critical need for a brief yet comprehensive assessment of disability that can be routinely and easily administered across health systems in clinical practice. In Phase 1 of this study, we will use psychometric (Rasch analysis) and clinical approaches to develop a short-form version of the HDQ (SF-HDQ). We will then use a combination of quantitative (questionnaires) and qualitative (interviews) with adults aging with HIV and HIV health providers to assess sensibility (face and content validity), utility, and optimal use of the SF-HDQ in clinical practice across three clinical sites in Denver Colorado, Toronto Canada and Dublin Ireland. In Phase 2, we will conduct a cross-sectional pilot study to examine the implementation and assess the measurement properties of the SF-HDQ with adults aging with HIV across the three health systems. Outcomes will yield the first known short form HIV-specific disability PRO developed through international, academic-community collaboration to assess prevalence and impact of episodic disability. Future universal measurement of disability may contribute to ongoing clinical management, specifically tracking of episodic disability trends and evaluation of interventions to inform allocation of resources to better promote healthy aging with HIV.

摘要 拟议研究的目的，是发展和试行一个简易表格， 针对艾滋病毒的残疾调查问卷，旨在促进感染艾滋病毒的成年人的健康老龄化。 具体目标是：1）开发和评估一种新的艾滋病毒特异性残疾简式量表的效用 在多个临床实践环境中对老年艾滋病毒感染者进行问卷调查，以及2）进行试点 实施新的艾滋病毒专用残疾简式问卷，并评估其 测量属性，同时收集有关存在、严重性和 美国艾滋病毒和多发病成年人残疾的偶发性 美国、加拿大和爱尔兰。标准化患者报告结局（PRO），旨在 捕捉残疾的性质和程度及其随时间的波动对于指导 为感染艾滋病毒的成年人提供及时和适当的护理。在工作的早期阶段， 我们制定了一个69项的患者报告结果（PRO），称为艾滋病毒残疾 调查问卷（HDQ），并证明其信度和效度的成人艾滋病毒感染者， 加拿大和爱尔兰。随着越来越多的成年人感染艾滋病毒和多发病， 对残疾进行简要而全面的评估是一项迫切需要， 易于在临床实践中跨卫生系统管理。在本研究的第1阶段，我们将 使用心理测量（Rasch分析）和临床方法来开发一个简短的版本， HDQ（SF-HDQ）。然后，我们将使用定量（问卷）和 与艾滋病毒感染者和艾滋病毒卫生提供者进行定性（访谈），以评估敏感性 (face和内容效度）、实用性和SF-HDQ在临床实践中的最佳使用 位于科罗拉多丹佛、加拿大多伦多和爱尔兰都柏林的三个临床研究中心。在第二阶段，我们将 进行一项跨部门的试验研究，以检查实施情况，并评估 SF-HDQ的测量特性与成年人在三个健康 系统.结果将产生第一个已知的简短形式的艾滋病毒特异性残疾PRO开发 通过国际学术界合作，评估 偶发性残疾未来残疾的通用测量可能有助于正在进行的临床 管理，特别是跟踪偶发残疾趋势和评价干预措施， 以更好地促进艾滋病毒感染者健康老龄化。