Identifying the correlates and trajectory of academic and clinical anxiety symptoms in children with reading disabilities

项目摘要 阅读障碍（RD）儿童患焦虑症的风险是正常儿童的两倍。 这种并发症严重影响儿童的生活质量和福祉。 我们小组和其他人的工作表明，焦虑症状非常普遍，而且会造成损害，但 在绝大多数患有RD的儿童中仍然没有得到评估和治疗。在这份提案中，我们的目标是定义 RD儿童阅读和其他临床焦虑症状的相关性和轨迹， 目标集中在焦虑亚型的分化（目标1），学术和认知相关的 焦虑症状（目标2和3），和焦虑症状的发展轨迹（目标4），在儿童与 Rd.这些目标中的每一个都旨在确定具有高翻译潜力的机制， 评估和预防/治疗目标。目标将通过两个样本，一个诊所来实现- 一个是社区，一个是社区。临床参考样本将由N~600名6-17岁儿童组成（ 与项目I合作），将通过内部发展神经心理学培训招募 DU和CU Boulder的诊所。以社区为基础的样本包括N=230名8-12岁的儿童， 过去的LDRC周期，我们将跟踪谁纵向5年后，当他们是13-17岁。的 项目II研究团队采用跨学科协作方法， 残疾和儿童心理健康领域，并响应RFA的要求，“产生新的科学 通过以下方式了解特定学习障碍（SLD）和共病状况的知识 协同的、综合的、基于团队的跨学科科学。”我们专注于临床参考样本 解决了RFA“拥抱研究SLD在真实的世界的复杂性， 多种共病或同时发生的情况”，我们在本申请中利用了几种资源， 将使我们的临床神经心理学服务和由此产生的研究管道更容易获得财政支持。 由于我们长期的临床研究，我们处于独特的地位，以实现这些目标 伙伴关系和我们在学习障碍和青少年焦虑方面的专业知识。总的来说，这些目标反映了一些 最早的工作特点的相互作用的阅读和焦虑，并将有助于新的见解与高 翻译潜力的评估，预防和干预儿童共病焦虑和RD。 第二个计画的重点是中心更大的目标，即了解学习障碍的并发症。 和心理健康，并将产生关键的发现，告知遗传，成像，神经心理学， 中心的目标。

Project Summary Children with reading disabilities (RD) have twice the risk of developing an anxiety disorder compared to typically-developing peers, and this comorbidity significantly impacts children’s quality of life and well-being. Work from our group and others suggests that anxiety symptoms are very common and impairing, and yet remain unassessed and untreated in the vast majority of children with RD. In this proposal, we aim to define the correlates and trajectory of reading and other clinical anxiety symptoms in children with RD through four aims focused on the differentiation of anxiety subtypes (Aim 1), the academic and cognitive correlates of anxiety symptoms (Aims 2 & 3), and the developmental trajectory of anxiety symptoms (Aim 4) in children with RD. Each of these aims is designed to identify mechanisms that have high translational potential for assessment and prevention/treatment targets. The aims will be accomplished using two samples, one clinic- referred and one community-based. The clinic-referred sample will consist of N~600 children, ages 6-17 (in collaboration with Project I) who will be recruited through the in-house developmental neuropsychology training clinics at DU and CU Boulder. The community-based sample consists of N=230 children ages 8-12 recruited in the past LDRC cycle and who we will follow longitudinally 5 years later when they are 13-17 years old. The Project II research team exemplifies an interdisciplinary collaborative approach that bridges the learning disabilities and child mental health fields and is responsive to the RFA request to “generate new scientific knowledge to inform understanding of specific learning disorders (SLDs) and comorbid conditions through synergistic, integrated, team-based transdisciplinary science.” Our focus on a clinically referred sample addresses the RFA to “embrace the complexities of studying SLDs in the real world inclusive of the context of multiple comorbid or co-occurring conditions” and we have leveraged several resources in this application that will make our clinical neuropsychological services and resulting research pipeline more financially accessible. We are uniquely positioned to accomplish these aims because of our long-standing clinical-research partnerships and our expertise in learning disabilities and youth anxiety. Overall, these aims reflect some of the earliest work characterizing the interplay of reading and anxiety and will contribute novel insights with high translational potential for assessment, prevention, and intervention for children with comorbid anxiety and RD. Project II is squarely focused on the larger Center aim of understanding the comorbidity of learning disabilities and mental health and will generate key findings that inform the genetic, imaging, neuropsychological, and intervention goals of the Center.