Massachusetts AI and Technology Center for Connected Care in Aging and Alzheimer's Disease (MAITC): Pilot (AD ADRD Focus)

项目摘要：AD/ADRD试点核心 阿尔茨海默病和相关痴呆症(AD/ADRD)核心在实现这些目标方面发挥着核心作用 马萨诸塞州老龄化和阿尔茨海默病互联护理技术中心 (MAITC)通过确定、选择、建议和帮助转化使用新兴技术的创新试点项目 人工智能增强技术，以解决AD/ADRD中临床和社会上未得到满足的需求。AD/ADRD试点 CORE将利用MAITC内的集体临床、科学和技术专长以及宝贵的投入 我们的利益相关者核心和行业咨询委员会以完成以下具体目标：1)征集和 选择最有价值的试点研究，这些研究将开发和测试新的人工智能增强技术，以解决 AD/ADRD中的临床重要问题；2)为飞行员提供指导、监督和资源支持 项目调查员；3)协助试点项目调查员改进方法并翻译 用于临床、工业和研究的技术。AD/ADRD试点核心领导人(博士贾斯米尔 Chhatwal和Deborah Blacker)将与MAITC的其他核心领导合作，协调和监督试点 项目流程。AD/ADRD试点核心将从培训方案、部门和 全国各地的大学和研究机构的中心，利用现有的大量 在神经学、精神病学、老年病学、技术、计算机等领域拥有专业知识的调查人员 科学和人工智能。AD/ADRD试点项目的示范专题领域包括：(1)评估 患者家庭环境中与认知障碍相关的安全问题；(2)评估对 医疗和行为干预与促进健康的潜在保护性行为 认知障碍；以及(3)为有关护理水平过渡和 在家中或家外需要照料帮助。一旦选定，每个试点项目负责人将被 指派两名导师(至少其中一人将具有AD/ADRD临床专业知识)，他们将提供研究 指导和便利获得所需资源。AD/ADRD Pilot Core将与其他MIATC一起工作 核心和AITC协调中心，以确保科学的完整性、严谨性和可重复性，并促进 IRB批准、人类主体安全、财务管理和监管批准。AD/ADRD试点 CORE将帮助试点研究人员确定关键的下一步，以使他们的创新更接近临床和 研究用途。为此，我们将为试点调查人员提供资源，以完善他们的技术，使 与业界联系，并制定新的赠款建议，以加快新技术向 AD/ADRD试点核心的最终目标--改善患者和照顾者的护理和生活质量 受AD/ADRD影响。

PROJECT SUMMARY: AD/ADRD Pilot Core The Alzheimer's Disease and Related Dementias (AD/ADRD) Core plays a central role in achieving the goals of the Massachusetts AI and Technology Center for Connected Care in Aging and Alzheimer's Disease (MAITC) by identifying, selecting, advising, and helping to translate innovative pilot projects that use emerging AI-enhanced technologies to address clinically and societally unmet needs in AD/ADRD. The AD/ADRD Pilot Core will draw on the collective clinical, scientific, and technical expertise within MAITC and the valuable input of our Stakeholder Core and Industry Advisory Board to complete the following specific aims: 1) Solicit and select the most meritorious pilot studies that will develop and test novel AI-enhanced technologies that address clinically important questions in AD/ADRD; 2) Provide mentorship, oversight, and resource supports for pilot project investigators; 3) Assist pilot project investigators in refining their methods and translating their technologies for clinical, industry, and research use. The AD/ADRD Pilot Core Leaders (Drs. Jasmeer Chhatwal and Deborah Blacker) will work MAITC’s other core leaders to coordinate and oversee the pilot project process. The AD/ADRD Pilot Core will solicit pilot projects from the training programs, departments, and centers at universities and research institutions across the nation, drawing on an extensive pool of existing investigators who have expertise in areas such as neurology, psychiatry, geriatrics, technology, computer science, and artificial intelligence. Example topic areas for AD/ADRD pilot projects include: (1) Assessing cognitive impairment-related safety concerns in the patient's home environment; (2) Assessing responses to medical and behavioral interventions and promotion of healthy, potentially-protective behaviors in patients with cognitive impairment; and (3) Informing critical but difficult decisions regarding level-of-care transitions and the need for caregiving assistance inside or outside the home. Once selected, each pilot project leader will be assigned two mentors (at least one of whom will have AD/ADRD clinical expertise) who will provide research guidance and facilitate access to needed resources. The AD/ADRD Pilot Core will work with the other MIATC cores and the AITC Coordinating Center to ensure scientific integrity, rigor and reproducibility, and to facilitate IRB approvals, human subject safety, financial management, and regulatory approvals. The AD/ADRD Pilot Core will help pilot investigators identify critical next steps to move their innovations closer to clinical and research use. To this end, we will provide resources to pilot investigators to refine their technologies, make industry contacts, and develop new grant proposals to accelerate the movement of novel technologies towards the ultimate goal of the AD/ADRD Pilot Core—to improve the care and quality of life for patients and caregivers affected by AD/ADRD.