Kids First Data Resource Center (KFDRC): Harnessing Data-Driven Opportunities in the Present on behalf of the Future of Common Fund Data Ecosystem (CFDE)

多个PI提案的依据 本提案侧重于与首批共同基金发援委和 CFDE-CC回应“参与共同基金数据协调”的参与机会 建立共同基金数据生态系统中心（CFDE）”OTA-20-2005。我们提出的 作战行动跨越OT EOA中定义的3个关键领域，包括GTEx、LINCS、HUBMAP和 作为NIH互操作性工作的一部分， 共同基金数据生态系统（CFDE）的建立。 参与这项提案的四名调查人员具有不同的专业背景， 专业知识和研究工具，包括领导儿童第一DCC/DRP和CAVATICA 努力 在费城儿童医院，亚当·雷斯尼克博士是一名癌症和神经科学研究 科学家与儿科脑肿瘤的专业知识和博士艾莉森希思是一个计算机科学专家， 大规模数据生物信息学和计算机基础设施。这些专家将共同努力， CHOP项目团队。在圣贾斯汀大学中心医院，Vincent Ferretti博士 生物信息学软件用于大规模软件开发和计算基因组学。七点 Bridges，Jack DiGiovanna博士是基于云的生物信息学分析平台的专家， 可扩展、协作和可复制。 研究者职责 所有PI将分担责任，确保项目的道德行为，维护科学 项目的完整性、行政、监督和项目管理的协调。 博士Adam Resnick将担任联系PI。他将负责总体战略， 科学用例的优先级，并确保项目达到其科学影响的目标。 博士Heath将监督和促进所有技术里程碑和交付成果的完成， CDFE参与。Heath博士还将负责执行互操作性战略， CFDE和NIH IC堆栈。Ferretti博士将监督KFDRC门户网站开发团队， 负责所有相关的可交付成果，例如NIH RAS认证和可视化 与LINCS集成。DiGiovanna博士将监督CAVATICA开发团队， 负责所有相关交付成果，例如GA 4GH DRS集成和多云 能力的 通信和数据共享 PI将每周与其他组织的PI进行沟通，并每月与其他组织的PI举行电话会议， 讨论CFDE和所有行政职责。此外，PI将亲自会见所有 至少每年一次，评估进展情况，并就发展方向作出重大决定。 程序.如果有必要进行更改，PI将共同讨论这些修改， 如有必要，重新分配资金。出版政策将建立在相对科学的 PI和关键人员的贡献。Resnick博士将担任联系PI，并负责 向NIH提交进度报告、年度报告和所有其他沟通。

Rationale for Multiple PI Proposal This proposal focuses on activities and collaborations with an initial set of Common Fund DCCs and the CFDE-CC in response to the Engagement Opportunity “Engaging Common Fund Data Coordinating Centers to Establish the Common Fund Data Ecosystem (CFDE)” OTA-20-2005. Our proposed engagements span the 3 key areas defined in the OT EOA and include GTEx, LINCS, HUBMAP, and SPARC as well as the activities the Kids First DRC is leading as part of the NIH Interoperability Working Group to further the establishment of the Common Fund Data Ecosystem (CFDE). The four investigators collaborating on this proposal have distinct professional backgrounds, areas of expertise, and research tools at their disposal including leading the Kids First DCC/DRP and CAVATICA efforts. At the Children’s Hospital of Philadelphia, Dr. Adam Resnick is a cancer and neuroscience research scientist with expertise in pediatric brain tumors and Dr. Allison Heath is a computer science expert in large-scale data bioinformatics and compute infrastructure. These experts will work together to lead the CHOP project team. At Centre Hospitalier Universitaire Sainte-Justine, Dr. Vincent Ferretti develops bioinformatics software for both large-scale software development and computational genomics. At Seven Bridges, Dr. Jack DiGiovanna is an expert in cloud-based analysis platforms for bioinformatics that are scalable, collaborative, and reproducible. Responsibilities of Investigators All PIs will share responsibility for ensuring the ethical conduct of the project, upholding the scientific integrity of the project, administration, oversight and coordination of the project’s management. Dr. Adam Resnick will serve as the contact PI. He will be responsible for the overall strategy, determining the prioritization of scientific use cases, and ensuring that the project meets its goals of scientific impact. Dr. Heath will oversee and facilitate the completion of the technical milestones and deliverables across all CDFE engagements. Dr. Heath will also be responsible for the execution of interoperability strategies with CFDE and the NIH IC Stacks. Dr. Ferretti will supervise the KFDRC portal development team and will be responsible for all of their relevant deliverables, such as authentication with NIH RAS and visualization integrations with LINCS. Dr. DiGiovanna will supervise the CAVATICA development team and will be responsible for all of their relevant deliverables, such as GA4GH DRS integration and multi-cloud capabilities. Communication and Data Sharing The PIs will communicate weekly and hold monthly teleconferences with PIs at the other organizations to discuss the CFDE and all administrative responsibilities. In addition, PIs will meet in person with all personnel at least annually to assess progress and make major decisions about the direction of the program. If changes are warranted, PIs will work together to discuss those modifications and the redistribution of funds, if necessary. A publication policy will be established based on the relative scientific contributions of the PIs and key personnel. Dr. Resnick will serve as contact PI and be responsible for submission of progress reports, annual reports to the NIH and all other communication.