Kids First Data Resource Center (KFDRC): Harnessing Data-Driven Opportunities in the Present on behalf of the Future of Common Fund Data Ecosystem (CFDE)

Kids First 数据资源中心 (KFDRC)：代表共同基金数据生态系统 (CFDE) 的未来，利用当前数据驱动的机会

• 批准号: 10907061
• 负责人: Jack DiGiovanna
• 金额: $ 259.35万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-25 至 2024-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10907061
• 关键词: Annual Reports; Area; Bioinformatics; Child; Childhood Brain Neoplasm; Collaborations; Communication; Computer software; Data; Data Coordinating Center; Development; Ensure; Ethics; Funding; Future; Genomics; Genotype-Tissue Expression Project; Goals; Human Resources; Infrastructure; Modification; Neurosciences Research; Pediatric Hospitals; Persons; Philadelphia; Policies; Progress Reports; Publications; Reproducibility; Research; Research Personnel; Scientist; Teleconferences; United States National Institutes of Health; Visualization; Work; anticancer research; cloud based; computer science; data ecosystem; data resource; data sharing; interoperability; large scale data; programs; response; software development; tool; working group

Rationale for Multiple PI Proposal This proposal focuses on activities and collaborations with an initial set of Common Fund DCCs and the CFDE-CC in response to the Engagement Opportunity “Engaging Common Fund Data Coordinating Centers to Establish the Common Fund Data Ecosystem (CFDE)” OTA-20-2005. Our proposed engagements span the 3 key areas defined in the OT EOA and include GTEx, LINCS, HUBMAP, and SPARC as well as the activities the Kids First DRC is leading as part of the NIH Interoperability Working Group to further the establishment of the Common Fund Data Ecosystem (CFDE). The four investigators collaborating on this proposal have distinct professional backgrounds, areas of expertise, and research tools at their disposal including leading the Kids First DCC/DRP and CAVATICA efforts. At the Children’s Hospital of Philadelphia, Dr. Adam Resnick is a cancer and neuroscience research scientist with expertise in pediatric brain tumors and Dr. Allison Heath is a computer science expert in large-scale data bioinformatics and compute infrastructure. These experts will work together to lead the CHOP project team. At Centre Hospitalier Universitaire Sainte-Justine, Dr. Vincent Ferretti develops bioinformatics software for both large-scale software development and computational genomics. At Seven Bridges, Dr. Jack DiGiovanna is an expert in cloud-based analysis platforms for bioinformatics that are scalable, collaborative, and reproducible. Responsibilities of Investigators All PIs will share responsibility for ensuring the ethical conduct of the project, upholding the scientific integrity of the project, administration, oversight and coordination of the project’s management. Dr. Adam Resnick will serve as the contact PI. He will be responsible for the overall strategy, determining the prioritization of scientific use cases, and ensuring that the project meets its goals of scientific impact. Dr. Heath will oversee and facilitate the completion of the technical milestones and deliverables across all CDFE engagements. Dr. Heath will also be responsible for the execution of interoperability strategies with CFDE and the NIH IC Stacks. Dr. Ferretti will supervise the KFDRC portal development team and will be responsible for all of their relevant deliverables, such as authentication with NIH RAS and visualization integrations with LINCS. Dr. DiGiovanna will supervise the CAVATICA development team and will be responsible for all of their relevant deliverables, such as GA4GH DRS integration and multi-cloud capabilities. Communication and Data Sharing The PIs will communicate weekly and hold monthly teleconferences with PIs at the other organizations to discuss the CFDE and all administrative responsibilities. In addition, PIs will meet in person with all personnel at least annually to assess progress and make major decisions about the direction of the program. If changes are warranted, PIs will work together to discuss those modifications and the redistribution of funds, if necessary. A publication policy will be established based on the relative scientific contributions of the PIs and key personnel. Dr. Resnick will serve as contact PI and be responsible for submission of progress reports, annual reports to the NIH and all other communication.

多项绩效指标提案的基本原理 本提案的重点是与一组初步的共同基金发改委和 CFDE-CC响应参与机会：参与共同基金数据协调 中心建立共同基金数据生态系统(CFDE)“OTA-20-2005。我们的建议 项目涉及OT EOA中定义的3个关键领域，包括GTEx、LINCS、HUBMAP和 作为NIH互操作性工作的一部分，SPARC以及儿童第一DRC正在领导的活动 小组进一步建立共同基金数据生态系统(CFDE)。 就这项提案进行合作的四名调查人员具有不同的专业背景， 专业知识和可用的研究工具，包括领导儿童首个DCC/DRP和CAVATICA 努力。 在费城儿童医院，亚当·雷斯尼克博士是一名癌症和神经科学研究人员 具有儿科脑瘤专业知识的科学家，艾莉森·希思博士是计算机科学专家 大规模数据生物信息学和计算机基础设施。这些专家将共同努力，领导 印章项目团队。在圣贾斯丁中心医院大学，文森特·费雷蒂博士开发出 用于大规模软件开发和计算基因组学的生物信息学软件。在七点 桥梁，Jack DiGiovanna博士是基于云的生物信息学分析平台方面的专家 可扩展、协作性和可重复性。 调查员的责任 所有PI将分担责任，确保项目的道德行为，维护科学 项目的诚信、管理、监督和项目管理的协调。 亚当·雷斯尼克博士将担任联系人PI。他将负责总体战略，确定 确定科学用例的优先顺序，并确保项目达到其科学影响的目标。 希思博士将监督和促进完成所有技术里程碑和交付成果 CDFE接洽。Heath博士还将负责执行互操作性策略 CFDE和NIH IC堆栈。费雷蒂博士将监督刚果民主力量门户开发团队，并将 负责他们的所有相关交付成果，如NIH RAS认证和可视化 与Lincs的集成。DiGiovanna博士将监督CAVATICA开发团队，并将 负责其所有相关交付内容，例如GA4GH DRS集成和多云 能力。 通信和数据共享 个人助理将每周与其他组织的个人助理举行电话会议，并每月举行电话会议，以 讨论CFDE和所有行政职责。此外，私家侦察将亲自与所有 人员至少每年评估进展并就发展方向作出重大决定 程序。如果需要更改，PI将共同讨论这些更改和 如有必要，重新分配资金。将在相对科学的基础上制定出版政策 绩效指标和关键人员的贡献。雷斯尼克博士将担任联络派并负责 向国家卫生研究院提交进度报告、年度报告和所有其他信息通报。