Engaging men through HIV self-test and differentiated care models to increase ART initiation and viral suppression in Malawi

通过艾滋病毒自检和差异化护理模式吸引男性参与，以增加马拉维的抗逆转录病毒治疗启动和病毒抑制

• 批准号: 10620317
• 负责人: Thomas J. Coates
• 金额: $ 51.54万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-17 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10620317
• 关键词: Address; Adverse event; Africa South of the Sahara; Baseline Surveys; Caring; Characteristics; Client; Clinical; Coping Skills; Cost Analysis; Cost Effectiveness Analysis; Decision Making; Diagnostic Reagent Kits; Disclosure; Enrollment; Epidemic; Female; Friends; Fright; Gender; Goals; HIV; HIV Seropositivity; Health Services Accessibility; Home; Human immunodeficiency virus test; Individual; Intention; International; Intervention; Interview; Joints; Knowledge; Location; Malawi; Modeling; Outcome; Perception; Phase; Policies; Population; Privacy; Public Health; Randomized, Controlled Trials; Recommendation; Reporting; Safety; Services; Sexual Partners; Testing; Time; Use Effectiveness; Viral; Viral Load result; Woman; Work; arm; cost; cost comparison; cost effective; cost effectiveness; cost-effectiveness ratio; design; effectiveness testing; experience; high risk men; improved; incremental cost-effectiveness; indexing; innovation; male; men; motivational enhancement therapy; novel strategies; peer; randomized trial; randomized, clinical trials; recruit; scale up; self testing; service delivery; social stigma; sociodemographics; standard of care; testing services; transmission process; treatment services; uptake

Project Summary Men continue to be missed by HIV testing and treatment services. Index partner testing is a critical strategy for reaching men. Index HIV self-testing (HIVST), whereby ART clients take HIVST kits home to their sexual partners for testing, is a new strategy that dramatically increases index testing among men, and is being taken to scale across Malawi. However, only 25% of men identified as HIV-positive through Index HIVST initiate ART after 6- months. Innovative strategies to increase ART initiation and retention among men are urgently needed. The overarching goal of the proposed R01 is to test a home-based ART intervention (ART initiation + 3-months ART care) plus motivational interviewing to increase ART initiation and 6-month viral suppression among men who test HIV-positive through Index HIVST in Malawi. The specific aims are: (1) test the effectiveness of home-based versus facility-based ART on ART initiation and 6-month viral suppression among male partners who test through Index HIVST; (2) Identify predictors of ART initiation and 6-month viral suppression; and (3) Determine the cost and cost-effectiveness of home-based ART versus facility-based among male partners using Index HIVST. The trial will provide urgent information on innovative HIV service delivery strategies for hard-to-reach-populations, such as men. Findings are expected to inform national policy and international recommendations around combined differentiated models that reach across the HIV treatment cascade.

项目总结

项目成果

Engaging men through HIV self-testing with differentiated care to improve ART initiation and viral suppression among men in Malawi (ENGAGE): A study protocol for a randomized control trial.

• DOI: 10.1371/journal.pone.0281472
• 发表时间: 2023
• 期刊: PloS one
• 影响因子: 3.7

Stakeholder Priorities for ART Initiation and Early Retention Interventions in Malawi: A Qualitative Study Comparing International and National Perspectives.

马拉维的利益相关者优先考虑 ART 启动和早期保留干预措施：一项比较国际和国家观点的定性研究。

• DOI: 10.21203/rs.3.rs-3725505/v1
• 发表时间: 2023
• 期刊: Research square
• 作者: Hariprasad,Santhi;Phiri,Khumbo;Thorp,Marguerite;Holland,Katherine;Nyirenda,Rose;Gupta,Sundeep;Phiri,Sam;Sabin,Lora;Dovel,Kathryn
• 通讯作者: Dovel,Kathryn

South Africa's male homicide epidemic hiding in plain sight: exploring sex differences and patterns in homicide risk in a retrospective descriptive study of postmortem investigations.

南非的男性凶杀流行病隐藏在人们的视线中：在尸检调查的回顾性描述性研究中探讨凶杀风险的性别差异和模式。

• DOI: 10.1101/2023.02.02.23285093
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Matzopoulos,R;Prinsloo,M;Mhlongo,S;Marineau,L;Cornell,M;Bowman,B;Mamashela,TA;Gwebushe,N;Ketelo,A;Martin,LJ;Dekel,B;Lombard,C;Jewkes,R;Abrahams,N
• 通讯作者: Abrahams,N

Improving ART initiation among men who use HIV self-testing in Malawi: a qualitative study.

• DOI: 10.1002/jia2.25950
• 发表时间: 2022-06
• 期刊: Journal of the International AIDS Society
• 影响因子: 6

Health care workers' perceptions and bias toward men as HIV clients in Malawi and Mozambique: A qualitative study.

• DOI: 10.1371/journal.pgph.0001356
• 发表时间: 2023
• 期刊: PLOS global public health