Expedited Partner Therapy and STI Control for MSM in Peru

秘鲁 MSM 的快速伴侣治疗和性传播感染控制

基本信息

  • 批准号:
    8153915
  • 负责人:
  • 金额:
    $ 17.91万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-07-01 至 2013-04-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Expedited Partner Therapy (EPT) has been shown to reduce rates of persistent or recurrent gonorrhea and chlamydia infection in heterosexual patients, but has not been evaluated for use among men who have sex with men (MSM). CDC guidelines support the use of EPT for partner management with heterosexual patients, but note the absence of evidence necessary to make an equivalent recommendation for the use of EPT with MSM. Randomized clinical trials to assess the impact of EPT on partner notification, treatment, and STI re- infection among MSM are critical to the development of evidence-based partner management guidelines. Our recent data from urban Peru has identified prevalences of rectal and pharyngeal gonorrhea and chlamydia ranging from 5-20%. The elevated burden of disease among MSM in Peru suggests that frequent transmission of undiagnosed gonorrhea and chlamydia through MSM sexual networks may be a factor contributing to the persistently high incidence of HIV infection among MSM in the region. We propose a pilot evaluation of the effect of EPT on partner notification and treatment among MSM in Peru diagnosed with gonorrhea or chlamydia at any anatomic site. Specific Aim 1: To explore the social norms and structural factors influencing partner notification and treatment among MSM in Peru. Specific Aim 2: To determine the effect of EPT on anticipated and actual partner notification among MSM diagnosed with gonorrhea or chlamydia infection. Specific Aim 3: To develop preliminary data on rates of gonococcal and chlamydial re-infection among MSM randomized to receive EPT compared with standard partner notification counseling. As a theoretical model, EPT integrates behavioral, social, and biomedical approaches to HIV/STI control in a comprehensive prevention intervention. Our proposed exploration of the social and behavioral dimensions of partner notification and treatment will provide a methodological structure for understanding the influence of EPT on behavioral decision-making processes, interpersonal factors that influence partner notification, and network patterns of STI transmission within MSM populations in Peru. Our biomedical assessment of gonorrhea and chlamydia re-infection will provide preliminary data to support the development of a definitive clinical trial of EPT for HIV/STI control in MSM populations. Practical issues including an evaluation of methods to assess notification and treatment rates, determination of the composition of participants' sexual networks (including the number of unlocatable partners in participant networks), and an overview of logistical issues involved in implementing and assessing an EPT intervention in the local environment, will all contribute to the development and refinement of a future trial of EPT for HIV/STI control with MSM. PUBLIC HEALTH RELEVANCE: STI co-infection is an important risk factor for HIV transmission during sexual intercourse, particularly among men who have sex with men (MSM). Expedited Partner Therapy (EPT) has been shown to be effective in controlling the spread of STIs in heterosexual partnerships, but has not been evaluated among MSM. We propose a pilot study of the impact of EPT on partner notification and treatment among MSM in Peru diagnosed with gonorrhea or chlamydia.
描述(由申请人提供):加速伴侣疗法(EPT)已被证明可以降低异性恋患者持续或复发性淋病和衣原体感染的发生率,但尚未评估其在男男性行为者(MSM)中的应用。美国疾病控制与预防中心的指南支持在异性恋患者的伴侣管理中使用EPT,但注意到缺乏必要的证据来推荐在男男性行为者中使用EPT。随机临床试验评估EPT对MSM性伴侣通报、治疗和性传播感染再感染的影响,对于制定循证性伴侣管理指南至关重要。我们最近来自秘鲁城市的数据已确定直肠和咽淋病和衣原体的患病率为5-20%。秘鲁男男性行为者疾病负担的增加表明,通过男男性行为者性网络频繁传播未确诊的淋病和衣原体可能是导致该地区男男性行为者艾滋病毒感染率持续高企的一个因素。我们建议试点评估EPT对秘鲁任何解剖部位诊断为淋病或衣原体的男男性行为者的伴侣通知和治疗效果。具体目标1:探讨影响秘鲁MSM伴侣通报和治疗的社会规范和结构性因素。目的2:探讨EPT对诊断为淋病或衣原体感染的男男性接触者预期性伴侣和实际性伴侣通报的影响。具体目标3:对随机接受EPT治疗的男男性接触者淋球菌和衣原体再感染率进行初步研究,并与标准性伴通知咨询进行比较。作为一种理论模型,EPT将行为、社会和生物医学方法整合到HIV/STI控制的综合预防干预中。我们提出的对伴侣通知和治疗的社会和行为维度的探索,将为理解EPT对行为决策过程的影响、影响伴侣通知的人际因素以及秘鲁MSM人群中性传播感染的网络模式提供一种方法结构。我们对淋病和衣原体再感染的生物医学评估将提供初步数据,以支持在MSM人群中开展EPT控制HIV/STI的明确临床试验。实际问题包括评估评估通报率和治疗率的方法,确定参与者性网络的组成(包括参与者网络中无法定位的伴侣的数量),以及概述在当地环境中实施和评估EPT干预所涉及的后勤问题,这些都将有助于开发和完善未来的EPT用于男男性接触者控制艾滋病毒/性传播感染的试验。

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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Thomas J. Coates其他文献

Behavioral self-management in treating sleep-maintenance insomnia
  • DOI:
    10.1007/bf00844846
  • 发表时间:
    1981-03-01
  • 期刊:
  • 影响因子:
    2.900
  • 作者:
    Carl E. Thoresen;Thomas J. Coates;Kathleen Kirmil-Gray;Mark R. Rosekind
  • 通讯作者:
    Mark R. Rosekind
Solid organ transplantation in HIV-positive patients.
HIV 阳性患者的实体器官移植。
  • DOI:
    10.1016/s0041-1345(01)02569-6
  • 发表时间:
    2001
  • 期刊:
  • 影响因子:
    0.9
  • 作者:
    Peter G. Stock;M. Roland;L. Carlson;C. Freise;R. Hirose;N. Terrault;Lynda A. Frassetto;Thomas J. Coates;J. Roberts;N. Ascher
  • 通讯作者:
    N. Ascher
Correction to: Barriers to Oral HIV Pre-exposure Prophylaxis (PrEP) Adherence Among Pregnant and Post-partum Women from Cape Town, South Africa
  • DOI:
    10.1007/s10461-022-03676-8
  • 发表时间:
    2022-04-21
  • 期刊:
  • 影响因子:
    2.400
  • 作者:
    Ivana Beesham;Kathryn Dovel;Nyiko Mashele;Linda-Gail Bekker;Pamina Gorbach;Thomas J. Coates;Landon Myer;Dvora Leah Joseph Davey
  • 通讯作者:
    Dvora Leah Joseph Davey
African-American adolescents residing in high-risk urban environments do use condoms: correlates and predictors of condom use among adolescents in public housing developments.
居住在高风险城市环境中的非裔美国青少年确实使用安全套:公共住房开发中青少年使用安全套的相关因素和预测因素。
  • DOI:
    10.1542/peds.98.2.269
  • 发表时间:
    1996
  • 期刊:
  • 影响因子:
    8
  • 作者:
    R. J. DiClemente;M. Lodico;O. Grinstead;Gary W. Harper;Richard L. Rickman;Patricia E. Evans;Thomas J. Coates
  • 通讯作者:
    Thomas J. Coates
New paradigms for disease management
  • DOI:
    10.1007/bf02603496
  • 发表时间:
    1996-01-01
  • 期刊:
  • 影响因子:
    4.200
  • 作者:
    Eliseo J. Pérez-Stable;Thomas J. Coates;Robert B. Baron;James O. Prochaska
  • 通讯作者:
    James O. Prochaska

Thomas J. Coates的其他文献

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{{ truncateString('Thomas J. Coates', 18)}}的其他基金

Engaging men through HIV self-test and differentiated care models to increase ART initiation and viral suppression in Malawi
通过艾滋病毒自检和差异化护理模式吸引男性参与,以增加马拉维的抗逆转录病毒治疗启动和病毒抑制
  • 批准号:
    10013734
  • 财政年份:
    2020
  • 资助金额:
    $ 17.91万
  • 项目类别:
Engaging men through HIV self-test and differentiated care models to increase ART initiation and viral suppression in Malawi
通过艾滋病毒自检和差异化护理模式吸引男性参与,以增加马拉维的抗逆转录病毒治疗启动和病毒抑制
  • 批准号:
    10196965
  • 财政年份:
    2020
  • 资助金额:
    $ 17.91万
  • 项目类别:
Engaging men through HIV self-test and differentiated care models to increase ART initiation and viral suppression in Malawi
通过艾滋病毒自检和差异化护理模式吸引男性参与,以增加马拉维的抗逆转录病毒治疗启动和病毒抑制
  • 批准号:
    10620317
  • 财政年份:
    2020
  • 资助金额:
    $ 17.91万
  • 项目类别:
Engaging men through HIV self-test and differentiated care models to increase ART initiation and viral suppression in Malawi
通过艾滋病毒自检和差异化护理模式吸引男性参与,以增加马拉维的抗逆转录病毒治疗启动和病毒抑制
  • 批准号:
    10415983
  • 财政年份:
    2020
  • 资助金额:
    $ 17.91万
  • 项目类别:
Evaluating the PrEP cascade in HIV-negative pregnant and breastfeeding women in South Africa (PrEP-PP)
评估南非 HIV 阴性孕妇和哺乳期妇女的 PrEP 级联 (PrEP-PP)
  • 批准号:
    9976615
  • 财政年份:
    2018
  • 资助金额:
    $ 17.91万
  • 项目类别:
Bringing South African Men into HIV Counseling and Testing (HCT) and Care
让南非男性接受艾滋病毒咨询和检测 (HCT) 和护理
  • 批准号:
    9107520
  • 财政年份:
    2015
  • 资助金额:
    $ 17.91万
  • 项目类别:
Bringing South African Men into HIV Counseling and Testing (HCT) and Care
让南非男性接受艾滋病毒咨询和检测 (HCT) 和护理
  • 批准号:
    9319824
  • 财政年份:
    2015
  • 资助金额:
    $ 17.91万
  • 项目类别:
Pilot Study of Skills-Building as HIV Prevention for Male Sex Workers in Peru
秘鲁男性性工作者艾滋病毒预防技能建设试点研究
  • 批准号:
    8708974
  • 财政年份:
    2013
  • 资助金额:
    $ 17.91万
  • 项目类别:
Pilot Study of Skills-Building as HIV Prevention for Male Sex Workers in Peru
秘鲁男性性工作者艾滋病毒预防技能建设试点研究
  • 批准号:
    8560430
  • 财政年份:
    2013
  • 资助金额:
    $ 17.91万
  • 项目类别:
Expedited Partner Therapy and STI Control for MSM in Peru
秘鲁 MSM 的快速伴侣治疗和性传播感染控制
  • 批准号:
    8277295
  • 财政年份:
    2011
  • 资助金额:
    $ 17.91万
  • 项目类别:

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