Driving Biomedical Projects - Functional genomics resources for the Drosophila

项目摘要-推动生物医学项目 我们已经确定了一组不同的驱动生物医学项目(DBP)，这些项目将作为 果蝇研究筛选中心的技术开发-生物医学技术研究 资源(DrSc-BTRR)。主题领域包括癌症治疗、罕见的遗传病、蚊子传播 传染病和基础研究，例如在细胞和发育生物学领域。我们 将与这些研究人员合作，确保技术由合作者测试，进一步开发和 由DrSc-BTRR改进，并应用于满足他们的研究需求。我们还将确保通过以下方式生成的数据 对于一个项目，用于改进所有相关项目，例如，这将与 CRISPR在果蝇和蚊子细胞中的共用屏幕，以及用于蚊子和蚊子的纳米抗体的开发 果蝇的目标。总而言之，我们的DBP处于有利地位，可以测试这些技术并从中受益，从而 在对各种基本和翻译主题提供新见解的研究中具有很强的潜力。

PROJECT SUMMARY – DRIVING BIOMEDICAL PROJECTS We have identified a diverse set of driving biomedical projects (DBPs) that will serve as test-beds for development of technologies by the Drosophila Research Screening Center-Biomedical Technology Research Resource (DRSC-BTRR). The topic areas include cancer therapeutics, rare genetic disease, mosquito-borne infectious diseases, and fundamental studies, for example in the areas of cell and developmental biology. We will work with these researchers to ensure that technologies are tested by collaborators, further developed and refined by the DRSC-BTRR, and applied to fit their research needs. We will also ensure that data generated by and for one project are used to improve all relevant projects, for example as will be relevant in the area of CRISPR pooled screens in Drosophila and mosquito cells, and in development of nanobodies for mosquito and Drosophila targets. Altogether, our DBPs are well-positioned to test and benefit from the technologies, resulting in studies with strong potential to provide new insights into a variety of fundamental and translational topics.