Functional genomics resources for the Drosophila and broader research communities

为果蝇和更广泛的研究界提供的功能基因组学资源

• 批准号: 10436790
• 负责人: NORBERT PERRIMON
• 金额: $ 135.6万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10436790
• 关键词: Animal Model; Area; Automobile Driving; Bioinformatics; Biology; Biomedical Technology; CRISPR/Cas technology; Cells; Cellular biology; Collaborations; Collection; Communicable Diseases; Communities; Consult; Consultations; Culicidae; Data; Data Analyses; Development; Developmental Biology; Disease; Disease Vectors; Drosophila genus; Educational workshop; Ensure; Funding; Future; Genetic Diseases; Genomics; Geographic state; Goals; Grant; Group Meetings; Health; Human; Human Genetics; Infrastructure; Insecta; Institutes; Institution; International; Knock-out; Laboratories; Longevity; Malignant Neoplasms; Maps; Measures; Medical; Methods; Mining; Modeling; Mosquito-borne infectious disease; National Institute of General Medical Sciences; Orthologous Gene; Paper; Plasmids; Privatization; Proteomics; Publications; Publishing; RNA Interference; RNA interference screen; Reagent; Research; Research Personnel; Resources; Services; Signal Transduction; Site; Study models; Technology; Technology Transfer; Testing; Therapeutic; Time; Training; Transgenic Organisms; United States National Institutes of Health; Universities; Visit; Work; base; bioinformatics resource; bioinformatics tool; career; college; data management; design; fly; functional genomics; genetic technology; genome wide screen; genome-wide; human disease; improved; in vivo; interest; large scale production; medical schools; member; new technology; online resource; overexpression; programs; rare genetic disorder; repository; screening; success; symposium; technology development; technology research and development; tool; vector mosquito; web site

PROJECT SUMMARY – OVERALL We will build on our existing infrastructure, expertise, and track-record to form the Drosophila Research and Screening Center-Biomedical Technology Research Resource (DRSC-BTRR). Our overall goal will be to help researchers realize the full potential of Drosophila as a model for the study of human health and disease, and as a model of medically-relevant insects such as mosquito vectors of infectious disease. The DRSC-BTRR will develop state-of-the-art tools and methods in three technology areas: (1) development of functional genomics technologies for Drosophila cell-based and in vivo studies (including CRISPR-Cas9 technologies); (2) application of functional genomic and proteomic technologies to mosquito vectors of human diseases; and (3) development of in vivo proteomics technologies for Drosophila. We will develop the technologies through iterative rounds of development, testing, and improvement together with a set of driving biomedical projects that can benefit from application of the technologies. To further extend the impact of the technologies, we will engage in community activities that inform a broad audience and rapidly disseminate technologies to other facilities to ensure long-term access. Altogether, we will serve as an integrated, collaborative resource engaging in projects with strong potential for impact in areas that are of interest to several NIH institutes, including fundamental cell and organismal biology, developmental biology, cancer therapeutics, rare genetic disorders, and mosquito-borne diseases.

项目总结-整体