CTSA UM1 Program at University of Utah

摘要 犹他州临床与翻译科学研究所(CTSI)的愿景是从战略和伦理上 开发和应用可推广且可重现的临床和转化科学(CTS)创新以 增加科学公平和健康公平，促进社会公平。犹他州CTSI与当地的 区域和国家合作伙伴和合作者通过四个具体目标实现这一愿景：(1)作为 一个公认的临床和转化科学中心，促进科学和健康公平 可衡量、可重复和可持续的方式。(2)设计、开发和测试创新翻译 科学的方法、工具、技术和最佳实践，以提高效率和重复性。(3)支持 实施和传播翻译科学创新以及教育和发展 翻译科学和研究队伍。(四)推动翻译研究的发展 从长凳到床边再到人群的发现，以改善个人和社区的健康， 缩小健康差距，改善健康公平。通过全面和一体化的员工队伍 发展计划，我们将培训下一代多样化的临床医生、实验室科学家、信息学家、 以及现代生物医学的翻译、伦理和团队科学方面的卫生服务科学家 研究。我们将创建一个新的模式和生态系统，让体验健康的利益相关者参与进来 差距，包括服务不足的种族/族裔人口、老年人、LGBTQ+成员 社区和西部山区的农村/边疆居民，以便：确保发出许多声音 在整个研究生命周期中被听到；(潜在的)研究参与者被告知、参与和 得到支持，以便所有人都能参与；并将研究结果转化为支持健康的护理 公平。通过我们的资源和服务，我们将提供利益相关者参与、研究设计和 犹他州CTSI社区的分析、信息学、伦理学和临床研究基础设施(包括 患者、社区成员、调查人员和提供者)。我们的翻译创新试点计划 将推出新颖的项目来解决可概括的翻译科学问题，克服障碍 加快转化型研究。我们将利用现代信息学技术来整合临床数据 以易于访问的格式提供健康和环境数据的社会决定因素，以便于 寻求了解这些因素如何导致健康差距的量化研究。我们的CTS 研究计划将实施一系列项目，以提高翻译研究的包容性 生命周期。我们的战略管理团队汇集了来自整个机构的经验丰富的领导者， 合作伙伴和合作者团结我们的努力，确保有效地管理和实施 犹他州CTSI的目标。我们的中心联络团队将确保我们有积极、多样化的合作伙伴参与 国家NCATS和CTSA的努力，并促进CTS创新在各枢纽的传播。

ABSTRACT The vision of the Utah Clinical & Translational Science Institute (CTSI) is to strategically and ethically develop and apply generalizable and reproducible clinical and translational science (CTS) innovations to increase science equity and health equity, and promote social justice. The Utah CTSI collaborates with local, regional, and national partners and collaborators to achieve this vision through four specific aims: (1) Serve as a well-recognized hub for clinical and translational science that promotes science and health equity in a measurable, reproducible, and sustainable manner. (2) Design, develop, and test innovative translational science methods, tools, techniques, and best practices to increase efficiency and reproducibility. (3) Support the implementation and dissemination of translational science innovations and the education and development of the translational science and research workforce. (4) Catalyze the advancement of translational research discoveries from bench to bedside to populations to improve the health of individuals and communities, reducing health disparities and improving health equity. Through comprehensive and integrated workforce development programs, we will train the next generation of diverse clinicians, bench scientists, informaticians, and health service scientists in the translational, ethical, and team science aspects of modern biomedical research. We will create a novel model and ecosystem for engaging stakeholders who experience health disparities, including underserved racial/ethnic populations, senior citizens, members of LGBTQ+ communities, and rural/frontier residents across the Intermountain West, in order to: ensure that many voices are heard throughout the research life cycle; (potential) research participants are informed, engaged, and supported so that participation is accessible to all; and findings are translated into care that supports health equity. Through our resources and services, we will provide stakeholder engagement, study design and analysis, informatics, ethics, and clinical research infrastructure to the Utah CTSI community (including patients, community members, investigators, and providers). Our Translational Innovation Pilot program will launch novel projects to address generalizable translational science questions, overcoming barriers to accelerate translational research. We will leverage modern informatics techniques to integrate clinical data with social determinants of health and environmental data in an easily accessible format to facilitate quantitative studies seeking to understand how these factors contribute to health disparities. Our CTS Research Program will conduct a series of projects to improve inclusiveness across the translational research lifecycle. Our Strategic Management Team brings together experienced leaders from across the institution, partners, and collaborators to unify our efforts, and ensure efficient administration and implementation of the Utah CTSI's aims. Our Hub Liaison Team will ensure that we have active, diverse partner participation in national NCATS and CTSA efforts, and promote dissemination of CTS innovations across hubs.