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University of Colorado Rocky Mountain NeuroNEXT (UNCOMON) Clinical Research Consortium.

科罗拉多大学落基山 NeuroNEXT (UNCOMON) 临床研究联盟。

基本信息

批准号：
10744629
负责人：
TIMOTHY A BENKE
金额：
$ 42.9万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-15 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10744629
关键词：
Acceleration Adult Advocacy Age Algorithms Area Behavioral Childhood Clinic Clinical Clinical Protocols Clinical Research Clinical Trials Clinical Trials Network Colorado Communication Community Outreach Contracts Data Databases Disease Enrollment Ensure Equity Ethics Faculty Funding Genetic Geography Goals Hospitals Immunologics Individual Informatics Infrastructure Institutional Review Boards Leadership Managed Care Medical Minority Minority Groups Monitor Movement Disorders Multi-Institutional Clinical Trial Native-Born Neurologic Neurology Neuropsychology Neurosciences Operations Research Patient Recruitments Patient Representative Patients Pediatric Hospitals Pediatric Neurology Pediatric Research Physicians Population Protocols documentation Qualifying Rare Diseases Recording of previous events Research Research Infrastructure Research Personnel Research Training Resources Rural Population Site Source Specialist Therapeutic Training Training Support Underserved Population Universities Work biobank care systems career clinical research site community engagement community partnership demographics design eHealth education resources experience hospital care investigator training medical specialties nervous system disorder neurogenetics neuroimaging neuromuscular neurosurgery next generation operation outreach patient advocacy group patient population patient retention pediatric department programs recruit skills support network therapeutic development

项目摘要

Effective clinical research into rare and ultra-rare neurologic and neurogenetic disorders requires a nationwide, collaborative network of neuroscience clinical research centers. The objective of the proposed University of Rocky Mountain NeuroNEXT Clinical Research Consortium (UNCOMON CRC) is to integrate expert from adult and child neurology, neurosurgery, neuroimaging, neuropsychology, and neurogenetics both the University of Colorado Hospital and Children's Hospital of Colorado on the University of Colorado Medical Campus into a large collaborative clinical research enterprise that exceeds start-up, retention, and operational goals of the NeuroNEXT network. The UNCOMON CRC is composed of recognized leaders in clinical research who have successfully participated in federally funded and multi-center clinical trials as well as local investigator-initiated therapeutic and biorepository The UNCOMON CRC will employ established clinical research and educational resources in conjunction a robust clinical research infrastructure to efficiently contribute to the NeuroNEXT network and advance the and research careers of the next generation of junior faculty nd fellows. We plan to achieve our goal the execution of the following specific aims: Aim 1: To establish a leadership network consisting of study adult and pediatric research directors, career enhancement director, DEI recruitment specialist, clinical coordinator, NeuroNEXT fellow, and operations manager; Aim 2: To establish an UNCOMON clinical consortium of collaborative co-investigators from adult and child neurology, neurosurgery, neuropsychology, and neurogenetics that encompass all subspecialty fields of clinical Aim 3: To establish a referral network to optimize recruitment and enhance outreach to minority and rural populations; and Aim 4: To develop and execute clinical research training and enhancement programs f or young i investigators using the collective expertise of the UNCOMON CRC. UNCOMON CRC will work efficiently to accelerate site qualification and IRB approval, employ multiple to optimize subject recruitment and retention, and carefully monitor research operations to ensure data a quality.

对罕见和超罕见的神经和神经遗传疾病进行有效的临床研究需要一个全国性的神经科学临床研究中心合作网络。落基山大学NeuroNEXT临床研究联盟（UNCOMON CRC）的目标是整合科罗拉多大学医学院的科罗拉多大学医院和科罗拉多儿童医院的成人和儿童神经病学、神经外科、神经影像学、神经心理学和神经遗传学专家，成为一个大型的协作临床研究企业，超越NeuroNEXT网络的启动、保留和运营目标。UNCOMON CRC由临床研究领域公认的领导者组成，他们成功参与了联邦政府资助的多中心临床试验以及当地研究者发起的治疗和生物库。UNCOMON CRC将利用已建立的临床研究和教育资源，结合强大的临床研究基础设施，有效地为NeuroNEXT网络做出贡献，并推进下一代初级教师的研究事业和同伴。我们计划实现以下具体目标：目标1：建立一个由成人和儿科研究主任、职业发展主任、DEI招聘专家、临床协调员、NeuroNEXT研究员和运营经理组成的领导网络；目标2：建立一个由来自成人和儿童神经病学、神经外科、神经心理学和神经遗传学的合作研究人员组成的UNCOMON临床联盟，涵盖临床的所有亚专科领域。目标3：建立一个转诊网络，以优化招募并加强对少数民族和农村人口的推广；目标4：利用UNCOMON CRC的集体专业知识，为年轻的临床研究人员制定和执行临床研究培训和增强计划。UNCOMON CRC将有效地加快场地资格和IRB批准，采用多种方法优化受试者招募和保留，并仔细监督研究操作以确保数据质量。