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University of Kansas Alzheimers Disease Center P30 Neuropathology supplement

堪萨斯大学阿尔茨海默病中心 P30 神经病理学补充

基本信息

批准号：
10741516
负责人：
RUSSELL H. SWERDLOW
金额：
$ 33.66万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-15 至 2026-06-30
项目状态：
未结题

项目摘要

PROJECT SUMMARY This Supplement requests one year of funding to support unforeseen costs associated with the University of Kansas Alzheimer’s Disease Research Center (KU ADRC) Neuropathology (NP) Core. The Neuropathology Core provides critical KU ADRC infrastructure in collaborating with other ADRC Cores (Figure 1). The neuropathology core function is essential to the Center’s mission and scientific theme by 1) Maintaining the autopsy program and Brain Bank; 2) Providing neuropathologic diagnosis, consultation, and training for investigators and trainees; 3) Obtaining dural and skin biopsies for induced pluripotent stem cell (IPSC) lines; and 4) Providing brain tissue for mitochondrial DNA (mtDNA) sequencing by the Biomarker Core. The NP Core continually upgrades it status to the diagnostic advances in the field and evolves according to the approved and accepted new guidelines, knowledge and state-of-the-art technology. Furthermore, the Core also participates in the important debates that produce these advances. An unanticipated growth in the number of investigators requesting NP Core support, an emergent unforeseen condition limiting our core to create a digital library of glass slides, increasing request for postmortem CSF specimens and an unpredicted obsolescence of our essential equipment to be replaced, predicates this request. We proposed in our recently funded P30 to provide open libraries of whole-slide scanned images to computer scientists and other investigators utilizing the scanners located in the department of pathology. However, due to increasing demand for neoplastic and other pathology specimens in the department, we have not been able to use this service properly as the current scanner is slow and the department cannot allocate proper time needed for our “research” projects. On the other hand, we have started working with computer scientists in different centers to utilize artificial intelligence (AI)/machine learning to quantify pathologic findings such as amyloid plaques and tangles in neurodegenerative diseases. However, the lack of access to a whole-slide scanner has incumbered our progress. Meanwhile, as the expectation was created, now we have increasing demand for a service we are unable to properly deliver and did not include its cost in submitted P30 budget. Secondly, we realize a need to extend our effort to collect postmortem cerebrospinal fluid to address increasing demand for this valuable specimen and assist our biomarker core for their biomarker studies. Neuropathology Core activities continue to rapidly grow, requiring a more comprehensive formal database program to support a higher level of Core documentation and inventory performance. Finally, we underestimated the rate of degeneration in our essential equipment such as tissue processor and microtome and their lack of extended technical support from their manufacturers for the coming years. For sustainable growth, we must replace them with a new reliable machine to be functional and supported for at least the next 10 years.

项目总结

项目成果

期刊论文数量（69）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Ease of use, feasibility and inter-rater reliability of the refined Cue Utilization and Engagement in Dementia (CUED) mealtime video-coding scheme.

精制提示利用和痴呆症（提示）进餐时间视频编码方案的提示利用和参与方案的易用性，可行性和评估者间的可靠性。

DOI：
10.1111/jan.14548
发表时间：
2020-12
期刊：
Journal of advanced nursing
影响因子：
3.8
作者：
Liu W;Batchelor M;Williams K
通讯作者：
Williams K

Examining the Role of a Functional Deficiency of Iron in Lysosomal Storage Disorders with Translational Relevance to Alzheimer's Disease.

DOI：
10.3390/cells12222641
发表时间：
2023-11-16
期刊：
Cells
影响因子：
6
作者：
通讯作者：

Rationale and methods for a multicenter clinical trial assessing exercise and intensive vascular risk reduction in preventing dementia (rrAD Study).

评估运动和强化血管风险降低预防痴呆症的多中心临床试验的基本原理和方法（rrAD 研究）。

DOI：
10.1016/j.cct.2019.02.007
发表时间：
2019
期刊：
Contemporary clinical trials
影响因子：
2.2
作者：
Szabo-Reed,AmandaN;Vidoni,Eric;Binder,EllenF;Burns,Jeffrey;Cullum,CMunro;Gahan,WilliamP;Gupta,Aditi;Hynan,LindaS;Kerwin,DianaR;Rossetti,Heidi;Stowe,AnnM;Vongpatanasin,Wanpen;Zhu,DavidC;Zhang,Rong;Keller,JeffreyN
通讯作者：
Keller,JeffreyN

Cardiovascular contributions to dementia: beyond individual risk factors.

心血管对痴呆症的影响：超越个体危险因素。