Global Network for Women's and Children's Health Research Data Coordinating Center

全球妇女和儿童健康网络研究数据协调中心

• 批准号: 10744384
• 负责人: Elizabeth M McClure
• 金额: $ 169.86万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2030-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10744384
• 关键词: Address; Affect; Biometry; Budgets; Child; Child Health; Child Mortality; Clinical Trials; Clinical Trials Data Monitoring Committees; Collaborations; Common Data Element; Communication; Communities; Community Health; Country; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Management Resources; Developing Countries; Development; Ensure; Epidemiology; Equipment and Supplies; Funding; Goals; Government; Grant; Health; Health Policy; Human Resources; Infant; Infant Development; Information Systems; International; Intervention; Investigational Drugs; Knowledge; Lactation; Manuals; Maternal Health; Maternal Mortality; Maternal and Child Health; Monitor; National Institute of Child Health and Human Development; Neonatal Mortality; Network Infrastructure; Newborn Infant; Online Systems; Outcome; Peer Review; Perinatal; Persons; Phase; Policies; Population Heterogeneity; Principal Investigator; Process; Productivity; Protocols documentation; Public Health; Publications; Qualifying; Research; Research Design; Research Infrastructure; Research Personnel; Research Support; Resources; Role; Services; Site; Statistical Data Interpretation; Structure; Sustainable Development; System; Telecommunications; Training; United States Food and Drug Administration; United States National Institutes of Health; Woman; computer program; cost effective; data management; data quality; data sharing; design; evidence base; experience; flexibility; global health; health economics; improved; improved outcome; infant morbidity/mortality; low and middle-income countries; maternal morbidity; meetings; multidisciplinary; neonatal health; nutrition; operation; outreach; participant safety; pregnant; public health intervention; recruit; stillbirth; usability; vision development

Project Summary/Abstract To improve women’s and children’s health and make progress in addressing the U.N.’s Sustainable Development Goals (SDGs), there is a need to continue researching sustainable, cost-effective health interventions and strengthening research infrastructure and public health intervention capabilities in developing countries. The NICHD Global Network (GN) is critical to helping the U.S. government address the SDGs to reduce maternal mortality and end preventable newborn and child mortality. There is a crucial need for an independent Data Coordinating Center (DCC) to provide statistical and operational expertise that helps the GN complete high-impact research to influence policy. RTI has been the GN’s DCC since 2001 and proposes to continue in this role for the next cycle. We will maximize the global impact of the GN and ensure a productive and accessible GN by collaborating with study investigators—both within and outside the Network—to develop rigorous and relevant Network research protocols and budgets. We will ensure seamless incorporation of research protocols developed by both GN and non-Network investigators through systems developed to inform study design using knowledge of the GN sites. (1) Optimize the scientific quality and operational efficiency of GN studies by supporting protocol design, training, implementation, and study monitoring; developing rigorous statistical analysis plans; incorporating common data elements; and effectively procuring external services, as needed, to support the research implementation. (2) Ensure high- quality data collection and data management, rigorous monitoring of study progress, quality, and participant safety. (3) Maximize the validity and scientific impact of Network research by providing timely, accurate statistical analyses of GN research to support publication of study results; ensuring timely dissemination and public sharing of data at study completion; and supporting study oversight by the Data Safety Monitoring Board, the Steering Committee, research units, NICHD. (4) Enhance the efficiency, productivity, and outreach of Network operations to Network and non-Network investigators by providing broad logistical support, including telecommunications, meeting coordination and organization, web-based internal and external communication systems, and regulatory support. Dr. Elizabeth McClure, the proposed PI, has extensive experience in maternal and newborn studies, and will be assisted by senior research staff with significant GN experience. This application has unique strengths to help advance the GN research agenda: (1) a highly qualified, collaborative PI and staff with in-depth knowledge; (2) proven track record of scientific productivity and leveraging the GN infrastructure to address emerging issues to advance NICHD scientific goals; (3) robust data systems customized for the GN to ensure data quality for harmonized research; (4) experts in biostatistics, epidemiology, community health, nutrition, infant development, and health economics; and (5) a flexible administrative structure to help realize the NICHD vision to optimize the GN.

项目摘要/摘要 改善妇女和儿童的健康，并在解决联合国可持续性方面取得进展 开发目标（SDG），有必要继续研究可持续性，成本效益的健康 干预措施和加强研究基础设施和公共卫生干预能力 发展中国家。 NICHD全球网络（GN）对于帮助美国政府解决这个问题至关重要 可持续发展目标以降低孕产妇死亡率并结束可预防的新生儿和儿童死亡率。有至关重要的需求 为了使一个独立的数据协调中心（DCC）提供统计和运营专家 帮助GN完成高影响力研究以影响政策。自2001年以来，RTI一直是GN的DCC 并建议在下一个周期中继续担任这一角色。我们将最大化GN的全球影响 通过与研究调查人员合作确保富有成效且可访问的GN，包括内外 网络 - 开发严格且相关的网络研究协议和预算。我们将确保 GN和非网络调查人员开发的研究方案的无缝合并。 开发了用于使用GN站点知识为研究设计提供信息的系统。 （1）优化科学 通过支持协议设计，培训，实施和 研究监测；制定严格的统计分析计划；合并常见的数据元素；和 根据需要有效地采购外部服务以支持研究实施。 （2）确保高 高质量的数据收集和数据管理，严格监控研究进度，质量和参与者 安全。 （3）通过提供及时，准确的网络研究的有效性和科学影响最大化 GN研究的统计分析以支持研究结果的出版；确保及时传播和 在研究完成时公开共享数据；并支持数据安全监控的研究监督 董事会，指导委员会，研究单位，NICHD。 （4）提高效率，生产率和 通过提供广泛的后勤方式向网络和非网络调查人员提供网络操作 支持，包括电信，会议协调和组织，基于Web的内部和 外部通信系统和法规支持。拟议的PI伊丽莎白·麦克卢尔（Elizabeth McClure）博士 在孕产妇和新生儿研究方面的丰富经验，将由高级研究人员协助 GN的重要经验。该应用具有独特的优势来帮助推进GN研究议程： （1）具有深入知识的高素质，合作的PI和员工； （2）经过验证的科学记录 生产力和利用GN基础设施来解决新兴问题以提高NICHD科学 目标； （3）为GN定制的强大数据系统，以确保数据质量的统一研究； （4） 生物统计学，流行病学，社区健康，营养，婴儿发展和健康专家 经济学; （5）灵活的管理结构，以帮助实现NICHD愿景以优化GN。

项目成果

Disparities in interventions for child and maternal mortality.

• DOI: 10.1016/s0140-6736(12)60474-7
• 发表时间: 2012-03-31
• 期刊: LANCET
• 影响因子: 168.9
• 作者: Goldenberg, Robert L.;McClure, Elizabeth M.
• 通讯作者: McClure, Elizabeth M.

Women's Perceptions and Experiences of Domestic Violence: An Observational Study From Hyderabad, Pakistan.

• DOI: 10.1177/0886260515585533
• 发表时间: 2017-01
• 期刊: Journal of interpersonal violence
• 影响因子: 2.5
• 作者: Madhani FI;Karmaliani R;Patel C;Bann CM;McClure EM;Pasha O;Goldenberg RL
• 通讯作者: Goldenberg RL

Exposure of pregnant women to indoor air pollution: a study from nine low and middle income countries.

• DOI: 10.3109/00016340903473566
• 发表时间: 2010
• 期刊: Acta obstetricia et gynecologica Scandinavica
• 影响因子: 4.3
• 作者: Kadir MM;McClure EM;Goudar SS;Garces AL;Moore J;Onyamboko M;Kaseba C;Althabe F;Castilla EE;Freire S;Parida S;Saleem S;Wright LL;Goldenberg RL;Global Network Tobacco Study Group*
• 通讯作者: Global Network Tobacco Study Group*

Meat consumption is associated with less stunting among toddlers in four diverse low-income settings.

• DOI: 10.1177/156482651103200301
• 发表时间: 2011-09
• 期刊: Food and nutrition bulletin
• 影响因子: 1.9
• 作者: Krebs NF;Mazariegos M;Tshefu A;Bose C;Sami N;Chomba E;Carlo W;Goco N;Kindem M;Wright LL;Hambidge KM;Complementary Feeding Study Group
• 通讯作者: Complementary Feeding Study Group

Chlorhexidine vaginal and infant wipes to reduce perinatal mortality and morbidity: a randomized controlled trial.

• DOI: 10.1097/aog.0b013e3181e00ff0
• 发表时间: 2010-06
• 期刊: Obstetrics and gynecology
• 影响因子: 7.2
• 作者: Saleem S;Rouse DJ;McClure EM;Zaidi A;Reza T;Yahya Y;Memon IA;Khan NH;Memon G;Soomro N;Pasha O;Wright LL;Moore J;Goldenberg RL
• 通讯作者: Goldenberg RL