Global Network for Women's and Children's Health Research Data Coordinating Center

全球妇女和儿童健康网络研究数据协调中心

• 批准号: 10744384
• 负责人: Elizabeth M McClure
• 金额: $ 169.86万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2030-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10744384
• 关键词: Address; Affect; Biometry; Budgets; Child; Child Health; Child Mortality; Clinical Trials; Clinical Trials Data Monitoring Committees; Collaborations; Common Data Element; Communication; Communities; Community Health; Country; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Management Resources; Developing Countries; Development; Ensure; Epidemiology; Equipment and Supplies; Funding; Goals; Government; Grant; Health; Health Policy; Human Resources; Infant; Infant Development; Information Systems; International; Intervention; Investigational Drugs; Knowledge; Lactation; Manuals; Maternal Health; Maternal Mortality; Maternal and Child Health; Monitor; National Institute of Child Health and Human Development; Neonatal Mortality; Network Infrastructure; Newborn Infant; Online Systems; Outcome; Peer Review; Perinatal; Persons; Phase; Policies; Population Heterogeneity; Principal Investigator; Process; Productivity; Protocols documentation; Public Health; Publications; Qualifying; Research; Research Design; Research Infrastructure; Research Personnel; Research Support; Resources; Role; Services; Site; Statistical Data Interpretation; Structure; Sustainable Development; System; Telecommunications; Training; United States Food and Drug Administration; United States National Institutes of Health; Woman; computer program; cost effective; data management; data quality; data sharing; design; evidence base; experience; flexibility; global health; health economics; improved; improved outcome; infant morbidity/mortality; low and middle-income countries; maternal morbidity; meetings; multidisciplinary; neonatal health; nutrition; operation; outreach; participant safety; pregnant; public health intervention; recruit; stillbirth; usability; vision development

Project Summary/Abstract To improve women’s and children’s health and make progress in addressing the U.N.’s Sustainable Development Goals (SDGs), there is a need to continue researching sustainable, cost-effective health interventions and strengthening research infrastructure and public health intervention capabilities in developing countries. The NICHD Global Network (GN) is critical to helping the U.S. government address the SDGs to reduce maternal mortality and end preventable newborn and child mortality. There is a crucial need for an independent Data Coordinating Center (DCC) to provide statistical and operational expertise that helps the GN complete high-impact research to influence policy. RTI has been the GN’s DCC since 2001 and proposes to continue in this role for the next cycle. We will maximize the global impact of the GN and ensure a productive and accessible GN by collaborating with study investigators—both within and outside the Network—to develop rigorous and relevant Network research protocols and budgets. We will ensure seamless incorporation of research protocols developed by both GN and non-Network investigators through systems developed to inform study design using knowledge of the GN sites. (1) Optimize the scientific quality and operational efficiency of GN studies by supporting protocol design, training, implementation, and study monitoring; developing rigorous statistical analysis plans; incorporating common data elements; and effectively procuring external services, as needed, to support the research implementation. (2) Ensure high- quality data collection and data management, rigorous monitoring of study progress, quality, and participant safety. (3) Maximize the validity and scientific impact of Network research by providing timely, accurate statistical analyses of GN research to support publication of study results; ensuring timely dissemination and public sharing of data at study completion; and supporting study oversight by the Data Safety Monitoring Board, the Steering Committee, research units, NICHD. (4) Enhance the efficiency, productivity, and outreach of Network operations to Network and non-Network investigators by providing broad logistical support, including telecommunications, meeting coordination and organization, web-based internal and external communication systems, and regulatory support. Dr. Elizabeth McClure, the proposed PI, has extensive experience in maternal and newborn studies, and will be assisted by senior research staff with significant GN experience. This application has unique strengths to help advance the GN research agenda: (1) a highly qualified, collaborative PI and staff with in-depth knowledge; (2) proven track record of scientific productivity and leveraging the GN infrastructure to address emerging issues to advance NICHD scientific goals; (3) robust data systems customized for the GN to ensure data quality for harmonized research; (4) experts in biostatistics, epidemiology, community health, nutrition, infant development, and health economics; and (5) a flexible administrative structure to help realize the NICHD vision to optimize the GN.

项目概要/摘要 改善妇女和儿童的健康并在解决联合国可持续发展目标方面取得进展 发展目标（SDG），需要继续研究可持续、具有成本效益的健康 干预措施并加强研究基础设施和公共卫生干预能力 发展中国家。 NICHD 全球网络 (GN) 对于帮助美国政府解决这一问题至关重要 可持续发展目标旨在降低孕产妇死亡率并消除可预防的新生儿和儿童死亡率。有一个至关重要的需求 建立一个独立的数据协调中心（DCC）来提供统计和运营专业知识， 帮助 GN 完成影响政策的高影响力研究。自 2001 年以来，RTI 一直是 GN 的 DCC 并建议在下一个周期继续担任这一角色。我们将最大限度地发挥 GN 的全球影响力 通过与内部和外部的研究调查人员合作，确保 GN 富有成效且易于使用 网络——制定严格且相关的网络研究协议和预算。我们将确保 无缝整合 GN 和非网络研究人员开发的研究协议 开发系统是为了利用 GN 站点的知识为研究设计提供信息。 （一）优化科学化 通过支持协议设计、培训、实施和实施，提高 GN 研究的质量和运行效率 研究监测；制定严格的统计分析计划；合并通用数据元素；和 根据需要有效采购外部服务，以支持研究实施。 (2) 确保高 高质量的数据收集和数据管理，严格监控研究进度、质量和参与者 安全。 (3) 通过提供及时、准确的信息，最大限度地提高网络研究的有效性和科学影响力 对 GN 研究进行统计分析，以支持研究结果的发表；确保及时传播和 研究完成时公开共享数据；并支持数据安全监测部门的研究监督 董事会、指导委员会、研究单位、NICHD。 (4) 提高效率、生产力和 通过提供广泛的后勤服务，将网络运作范围扩展到网络和非网络调查人员 支持，包括电信、会议协调和组织、基于网络的内部和 外部通信系统和监管支持。拟议的 PI 伊丽莎白·麦克卢尔 (Elizabeth McClure) 博士 在孕产妇和新生儿研究方面拥有丰富的经验，并将得到高级研究人员的协助 丰富的 GN 经验。该应用程序具有独特的优势，可以帮助推进 GN 研究议程： (1) 高素质、协作性的 PI 和知识渊博的员工； (2) 科学的记录 生产力并利用 GN 基础设施解决新出现的问题，以推进 NICHD 科学发展 目标； (3) 为 GN 定制的强大数据系统，以确保协调研究的数据质量； (4) 生物统计学、流行病学、社区健康、营养、婴儿发育和健康领域的专家 经济学; (5) 灵活的管理结构，帮助实现 NICHD 优化 GN 的愿景。

项目成果

Exposure of pregnant women to indoor air pollution: a study from nine low and middle income countries.

• DOI: 10.3109/00016340903473566
• 发表时间: 2010
• 期刊: Acta obstetricia et gynecologica Scandinavica
• 影响因子: 4.3
• 作者: Kadir MM;McClure EM;Goudar SS;Garces AL;Moore J;Onyamboko M;Kaseba C;Althabe F;Castilla EE;Freire S;Parida S;Saleem S;Wright LL;Goldenberg RL;Global Network Tobacco Study Group*
• 通讯作者: Global Network Tobacco Study Group*

Disparities in interventions for child and maternal mortality.

• DOI: 10.1016/s0140-6736(12)60474-7
• 发表时间: 2012-03-31
• 期刊: LANCET
• 影响因子: 168.9
• 作者: Goldenberg, Robert L.;McClure, Elizabeth M.
• 通讯作者: McClure, Elizabeth M.

Women's Perceptions and Experiences of Domestic Violence: An Observational Study From Hyderabad, Pakistan.

• DOI: 10.1177/0886260515585533
• 发表时间: 2017-01
• 期刊: Journal of interpersonal violence
• 影响因子: 2.5
• 作者: Madhani FI;Karmaliani R;Patel C;Bann CM;McClure EM;Pasha O;Goldenberg RL
• 通讯作者: Goldenberg RL

Meat consumption is associated with less stunting among toddlers in four diverse low-income settings.

• DOI: 10.1177/156482651103200301
• 发表时间: 2011-09
• 期刊: Food and nutrition bulletin
• 影响因子: 1.9
• 作者: Krebs NF;Mazariegos M;Tshefu A;Bose C;Sami N;Chomba E;Carlo W;Goco N;Kindem M;Wright LL;Hambidge KM;Complementary Feeding Study Group
• 通讯作者: Complementary Feeding Study Group

Chlorhexidine vaginal and infant wipes to reduce perinatal mortality and morbidity: a randomized controlled trial.

• DOI: 10.1097/aog.0b013e3181e00ff0
• 发表时间: 2010-06
• 期刊: Obstetrics and gynecology
• 影响因子: 7.2
• 作者: Saleem S;Rouse DJ;McClure EM;Zaidi A;Reza T;Yahya Y;Memon IA;Khan NH;Memon G;Soomro N;Pasha O;Wright LL;Moore J;Goldenberg RL
• 通讯作者: Goldenberg RL