Global Network for Women's and Children's Health Research Data Coordinating Center

项目摘要/摘要 改善妇女儿童健康，在应对联合国可持续发展问题上取得进展--S 为了实现可持续发展目标(SDGs)，有必要继续研究可持续、成本效益高的健康 干预措施和加强研究基础设施和公共卫生干预能力 发展中国家。NICHD全球网络(GN)对于帮助美国政府解决 可持续发展目标，以降低孕产妇死亡率，结束可预防的新生儿和儿童死亡率。有一种迫切的需要 为独立的数据协调中心(DCC)提供统计和业务专门知识，以 帮助GN完成影响政策的高影响力研究。RTI自2001年以来一直担任GN的DCC 并提议在下一个周期继续担任这一角色。我们将最大限度地发挥GN和 通过与内部和外部研究调查人员协作，确保高效和可访问的GN 网络-制定严格和相关的网络研究协议和预算。我们将确保 通过以下方式无缝整合GN和非网络调查人员开发的研究协议 开发了利用GN站点的知识为研究设计提供信息的系统。(一)优化科技兴业 通过支持协议设计、培训、实施和 研究监测；制定严格的统计分析计划；纳入共同数据要素；以及 根据需要有效地采购外部服务，以支持研究的实施。(2)确保高- 高质量数据收集和数据管理，严格监控研究进度、质量和参与者 安全。(3)通过提供及时、准确的信息，最大限度地提高网络研究的有效性和科学影响力 对GN研究进行统计分析，以支持研究结果的发布；确保及时传播和 在研究完成时公开共享数据；并支持数据安全监测对研究进行监督 理事会、指导委员会、研究单位、NICHD。(4)提高效率、生产力和 通过提供广泛的后勤，将网络业务扩展到网络和非网络调查人员 支助，包括电信、会议协调和组织、基于网络的内部和 外部通信系统和监管支持。伊丽莎白·麦克卢尔博士，被提议的私家侦探， 在孕产妇和新生儿研究方面有丰富的经验，并将得到高级研究人员的协助 重要的GN体验。该应用程序具有独特的优势，可帮助推进GN研究议程： (1)高素质、协作能力强的PI和具有深入知识的员工；(2)经过验证的科学记录 提高生产力和利用全球网络基础设施解决新出现的问题，以推动NICHD的科学 目标；(3)为全球网络量身定做的强大数据系统，以确保协调研究的数据质量；(4) 生物统计学、流行病学、社区健康、营养、婴儿发育和健康方面的专家 经济；以及(5)灵活的管理结构，以帮助实现NICHD的愿景，以优化GN。

Project Summary/Abstract To improve women’s and children’s health and make progress in addressing the U.N.’s Sustainable Development Goals (SDGs), there is a need to continue researching sustainable, cost-effective health interventions and strengthening research infrastructure and public health intervention capabilities in developing countries. The NICHD Global Network (GN) is critical to helping the U.S. government address the SDGs to reduce maternal mortality and end preventable newborn and child mortality. There is a crucial need for an independent Data Coordinating Center (DCC) to provide statistical and operational expertise that helps the GN complete high-impact research to influence policy. RTI has been the GN’s DCC since 2001 and proposes to continue in this role for the next cycle. We will maximize the global impact of the GN and ensure a productive and accessible GN by collaborating with study investigators—both within and outside the Network—to develop rigorous and relevant Network research protocols and budgets. We will ensure seamless incorporation of research protocols developed by both GN and non-Network investigators through systems developed to inform study design using knowledge of the GN sites. (1) Optimize the scientific quality and operational efficiency of GN studies by supporting protocol design, training, implementation, and study monitoring; developing rigorous statistical analysis plans; incorporating common data elements; and effectively procuring external services, as needed, to support the research implementation. (2) Ensure high- quality data collection and data management, rigorous monitoring of study progress, quality, and participant safety. (3) Maximize the validity and scientific impact of Network research by providing timely, accurate statistical analyses of GN research to support publication of study results; ensuring timely dissemination and public sharing of data at study completion; and supporting study oversight by the Data Safety Monitoring Board, the Steering Committee, research units, NICHD. (4) Enhance the efficiency, productivity, and outreach of Network operations to Network and non-Network investigators by providing broad logistical support, including telecommunications, meeting coordination and organization, web-based internal and external communication systems, and regulatory support. Dr. Elizabeth McClure, the proposed PI, has extensive experience in maternal and newborn studies, and will be assisted by senior research staff with significant GN experience. This application has unique strengths to help advance the GN research agenda: (1) a highly qualified, collaborative PI and staff with in-depth knowledge; (2) proven track record of scientific productivity and leveraging the GN infrastructure to address emerging issues to advance NICHD scientific goals; (3) robust data systems customized for the GN to ensure data quality for harmonized research; (4) experts in biostatistics, epidemiology, community health, nutrition, infant development, and health economics; and (5) a flexible administrative structure to help realize the NICHD vision to optimize the GN.