Environmental influences on Child Health Outcomes - The Colorado ECHO Pediatric Cohort

环境对儿童健康结果的影响 - 科罗拉多州 ECHO 儿科队列

• 批准号: 10744571
• 负责人: Traci Allison Bekelman
• 金额: $ 161.28万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10744571
• 关键词: Address; Adolescence; Age; Area; Asthma; Behavior; Behavioral; Biogenesis; Biological; Biology; Birth; Body Size; Caregivers; Chemicals; Child; Child Health; Childhood; Chronic; Chronic Disease; Collaborations; Collection; Colorado; Communities; DNA Methylation; Data; Deposition; Development; Developmental Disabilities; Diagnosis; Disease; Disparity; Early identification; Environmental Exposure; Environmental Health; Epigenetic Process; Ethnic Population; Exposure to; Family; Fatty acid glycerol esters; Growth; Health; Health behavior; Household; Individual; Institution; Joints; Knowledge; Lead; Life; Link; Mediating; Mental Depression; Metabolic; Methodology; Mothers; Neighborhoods; Obesity; Outcome; Overnutrition; Participant; Pathway interactions; Pattern; Pediatric cohort; Phenotype; Physiology; Pregnancy; Prevalence; Preventive; Protocols documentation; Psychosocial Stress; Publications; Research; Research Personnel; Risk Factors; Sampling Studies; Science; Shapes; Societies; Toddler; Visceral; Weight; Work; aged; cardiometabolism; cohort; coronavirus disease; disorder risk; early childhood; early life exposure; epidemiology study; experience; holistic approach; in utero; infancy; innovation; insight; metabolomics; middle childhood; neurodevelopment; novel; obesity development; obesity in children; offspring; pediatric health outcomes; postnatal; prenatal exposure; prevent; programs; promote resilience; psychosocial; racial population; recruit; resilience; response; retention rate; social; social stigma; trait

PROJECT SUMMARY/ABSTRACT Chronic conditions, such as obesity, asthma, depression, and developmental disabilities, are increasing among children worldwide. Further, the age at diagnosis for many such conditions is decreasing, pointing to early-life origins. The developmental origins of health and disease (DOHaD) paradigm posits that exposures and experiences in utero and during early life influence phenotype and physiology as well as behaviors that shape lifelong health. Epidemiologic studies of DOHaD phenomena have historically focused on single exposure-health outcome associations, despite calls for more holistic approaches to capture the totality of exposures and their causal pathways. Other important limitations of prior work include homogenous study samples that diminish generalizability and limit opportunities to identify disparities and infrequent or lack of granularity in assessment of exposures and health outcomes across ontogeny. Together, these limitations hamper identification of when and how risk factors and combinations of risk factors across early life culminate in chronic disease. This proposal addresses the above gaps by leveraging the Environmental influences on Child Health Outcomes (ECHO) Program to investigate a broad range of early-life exposures, from society to biology, in relation to pediatric health outcomes among ~50,000 caregiver-offspring pairs. The Colorado team will implement ECHO’s Core and Specialized Protocols in the Healthy Start Study, a Colorado pre-birth cohort that recruited and followed 1,250 mother-child dyads. In this cohort, exposures, and outcomes relevant to ECHO were collected during pregnancy, at birth, during infancy and the toddler years, and in early childhood (4-5 years). In the first ECHO Cycle, the Colorado team followed 765 children, to date, through middle childhood (8-12 years) and transferred extant data from pregnancy onward to the ECHO platform. In response to RFA-OD-22-019 and in collaboration with other ECHO components, our team will implement the ECHO Cohort Data and Biospecimen Collection Protocol with high fidelity and use community-engaged retention strategies to follow 900 diverse participants aged 11-19 years to achieve two scientific objectives: (1) characterize patterns of structural, chemical, and physical exposures during the in utero period and early childhood that predict co-occurring clusters of major ECHO outcomes through adolescence; and (2) examine joint effects of exposure to in utero overnutrition and childhood psychosocial adversity on the Specialized Outcome of pediatric obesity. The work proposed will facilitate a holistic understanding of how the totality of early-life exposures and experiences shape chronic disease risk in children; examine the involvement of a potentially modifiable biological mechanism (DNA methylation); and provide insights into multi-level targets for preventive action, including family- and individual-level factors that build resiliency in the face of unfavorable early exposures. The Colorado team brings to ECHO a diverse group of investigators who are uniquely poised to lead innovative team science to steer solution-oriented research.

项目摘要/摘要 慢性疾病，如肥胖、哮喘、抑郁症和发育障碍，在 世界各地的儿童。此外，许多此类疾病的确诊年龄正在下降，这表明他们还处于早寿阶段。 起源。健康与疾病的发育起源(DOHAD)范式假设暴露和 宫内和早期生活中的经历影响表型和生理以及塑造行为 终身健康。DOHaD现象的流行病学研究历来侧重于单一暴露--健康 结果关联，尽管呼吁采取更全面的方法来捕捉暴露的总体情况及其 因果路径。先前工作的其他重要限制包括同质研究样本减少 可概括性和有限的机会，以确定差异和不经常或缺乏评估的粒度 个体发育过程中的暴露和健康结果。总而言之，这些限制阻碍了对 以及早期生活中的风险因素和风险因素的组合如何最终导致慢性病。这项建议 通过利用环境对儿童健康结果的影响(ECHO)来解决上述差距 计划调查与儿科有关的广泛的早期生命暴露，从社会到生物 约50,000对照顾者-后代的健康结果。科罗拉多州团队将实施Echo的核心和 健康开始研究中的专门方案，科罗拉多州的一个产前队列招募并跟踪了1250人 母子二人组。在这个队列中，与ECHO相关的暴露和结局是在怀孕期间收集的， 在出生时、婴儿期和学步期，以及儿童早期(4-5岁)。在第一个回声周期中， 到目前为止，科罗拉多州的研究小组跟踪调查了765名儿童，直到童年中期(8-12岁)，并转移了现有的数据 从怀孕到回声站台。响应RFA-OD-22-019并与其他 ECHO组件，我们的团队将通过以下方式实施ECHO队列数据和生物量采集协议 高保真并使用社区参与的保留策略跟踪900名11-19岁的不同参与者 实现两个科学目标：(1)确定结构、化学和物理暴露的模式 在宫内期和儿童早期，通过以下方式预测共同出现的主要回声结果簇 青春期；和(2)检查宫内营养过剩和童年心理社会的联合影响 儿童肥胖的特殊结局的逆境。拟议的工作将促进全面的 了解早期接触和经历如何塑造儿童的慢性病风险； 审查潜在的可修改的生物学机制(DNA甲基化)的参与；并提供 对预防行动的多层次目标的见解，包括家庭和个人层面的因素 在面对不利的早期暴露时的弹性。科罗拉多州的团队带来了一群不同的 独一无二地准备领导创新团队科学来指导面向解决方案的研究的研究人员。