Atlanta ECHO Pediatric Cohort: Examining -omics pathways from prenatal exposures to child neurodevelopment

亚特兰大 ECHO 儿科队列：检查从产前暴露到儿童神经发育的组学途径

• 批准号: 10744941
• 负责人: PATRICIA A BRENNAN
• 金额: $ 101.23万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10744941
• 关键词: 7 year old; Acceleration; Adherence; African American; Age; Age Months; Allergic; Anxiety; Area; Asthma; Attention deficit hyperactivity disorder; Behavior; Bifidobacterium; Biological; Birth; Black American; Child; Child Health; Clinical; Cohort Studies; DNA Repair; Data; Diet; Discrimination; Disease; Enrollment; Epigenetic Process; Executive Dysfunction; Exposure to; Family; Future; Genetic Transcription; Geographic Locations; Gestational Age; Health behavior; Individual; Intervention; Investigation; Lead; Low Birth Weight Infant; Maternal and Child Health; Measures; Mediating; Mediator; Mental Depression; Mental disorders; Metabolic Pathway; Mothers; National Institute on Minority Health and Health Disparities; Nerve Degeneration; Neurodevelopmental Disorder; Obesity; Outcome; Participant; Pathway interactions; Pediatric cohort; Perinatal; Phenotype; Physical activity; Post-Traumatic Stress Disorders; Postpartum Depression; Postpartum Period; Pregnancy; Pregnancy Complications; Premature Birth; Process; Protocols documentation; Psychopathology; Psychosocial Stress; Racial Segregation; Reporting; Research; Research Personnel; Risk; Role; Sampling; Science; Site; Sleep; Sleep disturbances; Social Functioning; Social support; Southeastern United States; Stress; Structural Racism; Testing; Variant; Visit; autism spectrum disorder; cognitive function; cohort; community intervention; design; disorder risk; early childhood; epigenome; ethnic minority; experience; follow-up; health disparity; improved; low socioeconomic status; maternal stress; metabolome; metropolitan; microbiome; multidisciplinary; neurodevelopment; novel; participant retention; pediatric health outcomes; perceived discrimination; perinatal health; perinatal outcomes; pregnancy health; prenatal; prenatal experience; prenatal exposure; prenatal health; prenatal stress; prospective; protective factors; protective pathway; psychological distress; psychosocial; racial discrimination; racial disparity; racial minority; racism; sleep quality; social; social cohesion; sociodemographics; stressor; substance use; systematic review

ABSTRACT Black Americans and other racial and ethnic minorities experience higher levels of psychosocial stress and are exposed to unique stressors, such as discrimination and structural racism. Prenatal psychosocial stress increases risk for a range of adverse maternal, perinatal and child neurodevelopmental outcomes. However, nationally representative samples with prospective data on maternal report of prenatal stress and discrimination and verified perinatal and child health outcomes are lacking, as are investigations that consider risk and protective pathways that reflect solution-oriented research. The ECHO Cohort is ideal for advancing solution-oriented science around maternal psychosocial stress exposures, perinatal risk pathways, and child health outcomes as the protocol includes measures of prenatal stress and experiences of discrimination, social support and cohesion, prenatal health behaviors (diet, physical activity, sleep, substance use), pregnancy complications and birth outcomes, and child health outcomes for a socio-demographically heterogenous, national sample. Geocoding efforts also enable the consideration of area level measures of structural racism, allowing for multi-level, multi-domain analyses in line with the NIMHD research framework for investigating health disparities. We seek to extend follow-up of our Atlanta ECHO Cohort participants under the ECHO Protocol and to participate in solution-oriented team science. Enrolled children are now 2 to 7 years old and will be followed with annual visits consistent with the ECHO Protocol, with a focus on child neurodevelopment as a specialized outcome area. The unique contributions of our Cohort Study site include our capacity to follow hard-to-reach racial and ethnic minority families (as our cohort is wholly composed of Black American families, 75% of whom are of lower socioeconomic status); our geographic location in a major metropolitan area in the US Southeast that experiences unique regional and area-level stressors (e.g., racialized segregation); and our multi-disciplinary team of psychosocial, clinical, and omic investigators with expertise in (personalized) exposure assessment, maternal stress, perinatal and birth outcomes, and child neurodevelopment. Given our team’s expertise, and preliminary data that supports an association between stress, omics pathways, and neurodevelopment, we plan to lead test novel hypotheses about how prenatal stress (including racial discrimination) leads to perturbations in the metabolome, epigenome and microbiome, and how these biological perturbations, in turn, predict child neurodevelopment. We will also test the role of racial discrimination experiences in children’s health outcomes in the ECHO cohort, as well as modifiable mediators (maternal prenatal sleep quality and postpartum depression) and moderators (social support) which will inform potential intervention strategies designed to improve children’s health outcomes.

抽象的 美国黑人和其他种族和族裔承受着更高水平的社会心理压力， 面临独特的压力源，例如歧视和结构性种族主义。产前社会心理压力 增加一系列不良孕产妇、围产期和儿童神经发育结果的风险。然而， 具有全国代表性的样本，其中包含关于产妇产前应激报告的前瞻性数据 缺乏歧视和经过验证的围产期和儿童健康结果，也缺乏考虑到的调查 反映以解决方案为导向的研究的风险和保护途径。 ECHO 队列是推进的理想选择 围绕母亲社会心理压力暴露、围产期风险途径和儿童的以解决方案为导向的科学 健康结果，因为该议定书包括产前压力和歧视经历、社会 支持和凝聚力、产前健康行为（饮食、体力活动、睡眠、物质使用）、怀孕 社会人口异质性的并发症和出生结果以及儿童健康结果， 国家样本。地理编码工作还可以考虑结构性种族主义的地区级措施， 允许根据 NIMHD 研究框架进行多层次、多领域分析以进行调查 健康差异。我们寻求在 ECHO 下延长对亚特兰大 ECHO 队列参与者的随访 协议并参与以解决方案为导向的团队科学。报名儿童年龄为2至7岁，将 随后根据 ECHO 协议进行年度访问，重点关注儿童神经发育作为 专门成果领域。我们的队列研究网站的独特贡献包括我们遵循的能力 难以接触到的种族和少数族裔家庭（因为我们的队列完全由美国黑人家庭组成， 其中 75% 的社会经济地位较低）；我们的地理位置位于主要大都市区 美国东南部地区经历着独特的地区和地区层面的压力（例如种族隔离）；和我们的 由具有（个性化）专业知识的社会心理、临床和组学研究人员组成的多学科团队 暴露评估、孕产妇压力、围产期和出生结果以及儿童神经发育。鉴于我们的 团队的专业知识以及支持压力、组学途径和 神经发育，我们计划领导测试关于产前压力（包括种族压力）如何影响神经发育的新假设 歧视）导致代谢组、表观基因组和微生物组的扰动，以及这些扰动如何 反过来，生物扰动可以预测儿童的神经发育。我们还将测试种族的作用 ECHO 队列中儿童健康结果的歧视经历以及可修改的中介因素 （母亲产前睡眠质量和产后抑郁症）和主持人（社会支持）将提供信息 旨在改善儿童健康结果的潜在干预策略。