Oversight and Project Management Component

监督和项目管理部分 迫切需要精心设计的研究来检查环境暴露对健康的影响 儿童的成果。为了解决这些知识差距，环境对儿童健康的影响 结果（ECHO）计划承诺利用现有和新的儿科队列来测试以下新假设： 环境暴露如何影响儿科健康。杜克临床研究所（DCRI）建议 作为ECHO协调中心（ECHO CC）， 管理、指导和全面协调欧共体人道处的所有共同活动。DCRI是独一无二的， 领导这一雄心勃勃的计划。作为世界上最大的学术研究机构，DCRI管理着超过30个活跃的 网络和行政协调中心赠款，并已成为儿科临床的领导者 research.为了促进创新，严格的研究协议量身定制的科学假设; 在儿科队列网络中实施方案;并提供研究支持，以确保高质量 研究操作和及时完成，DCRI将建立ECHO CC监督和项目 管理组件。监督和项目管理部分的具体目标， Drs.布莱恩·史密斯和琳达·埃德尔将1）监督标准化ECHO的开发和实施 队列方案2）监测ECHO队列和单个队列研究中心的进展;以及3）协调 在整个ECHO计划中开展多样性、公平性、包容性和无障碍活动。监督和项目 管理部分将包括两个小组：研究开发和实施小组和 现场启动和进度团队。研究开发和实施团队将负责 促进ECHO队列方案的完善、审查和监测，特别是纳入 新的孕前章节和任何后续方案修订。网站激活和进度团队 将负责ECHO队列研究中心合作伙伴关系;研究中心管理和监测;以及 IRB支持。

OVERSIGHT AND PROJECT MANAGEMENT COMPONENT ABSTRACT Well-designed research is urgently needed to examine the impact of environmental exposures on health outcomes in children. To address these knowledge gaps, the Environmental influences on Child Health Outcomes (ECHO) program promises to leverage extant and new pediatric cohorts to test new hypotheses of how environmental exposures impact pediatric health. The Duke Clinical Research Institute (DCRI) proposes to serve as the ECHO Coordinating Center (ECHO CC) to provide the organizational framework for the management, direction, and overall coordination of all common ECHO activities. DCRI is uniquely poised to lead this ambitious initiative. As the world's largest academic research organization, DCRI manages >30 active network and administrative coordinating center grants and has emerged as a leader in pediatric clinical research. In order to facilitate innovative, rigorous study protocols tailored to the scientific hypotheses; implement protocols across a network of pediatric cohorts; and provide study support to ensure high quality study operations and timely completion, the DCRI will establish the ECHO CC Oversight and Project Management Component. The specific aims of the Oversight and Project Management Component, led by Drs. Brian Smith and Linda Adair, are to 1) oversee development and implementation of a standardized ECHO Cohort Protocol 2) monitor progress of the ECHO Cohort and individual Cohort Study Sites; and 3) coordinate diversity, equity, inclusion, and accessibility activities across the ECHO Program. The Oversight and Project Management Component will include two teams: the Study Development and Implementation Team and the Site Activation and Progress Team. The Study Development and Implementation Team will be responsible for facilitating the refinement, review, and monitoring of the ECHO Cohort Protocol, specifically incorporating the new preconception section and any subsequent protocol amendments. The Site Activation and Progress Team will be responsible for ECHO Cohort Study Site partnerships; site management and monitoring; and central IRB support.