Nonalcoholic fatty liver disease, associated lipidomic changes, and preeclampsia risk
非酒精性脂肪肝、相关脂质组学变化和先兆子痫风险
基本信息
- 批准号:10591257
- 负责人:
- 金额:$ 19.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-01 至 2027-07-31
- 项目状态:未结题
- 来源:
- 关键词:Active LearningAffectBiological MarkersBiometryBlack raceBlood VesselsBody mass indexCardiovascular DiseasesCardiovascular systemCaringClinicalClinical InvestigatorDataDevelopmentDevelopment PlansDiabetes MellitusDiscipline of obstetricsEicosanoidsEndothelial CellsEnvironmentEnzymesEpidemiologyEthnic OriginEthnic PopulationFunctional disorderFundingFutureGestational DiabetesGoalsHealthHealth systemHepaticHepatologyHigh PrevalenceHispanicHypertensionImpairmentIncidenceInfantInflammationInfrastructureInstitutionInterventionKnowledgeLipidsLiverLiver diseasesLongitudinal cohortMaternal HealthMaternal MortalityMeasuresMedicaidMentorshipMetabolicMetabolic syndromeMinority WomenObesityOutcomeOverweightPathogenesisPatientsPhysiciansPolyunsaturated Fatty AcidsPopulationPositioning AttributePostpartum PeriodPostpartum WomenPre-EclampsiaPregnancyPregnant WomenPremature BirthProspective StudiesProspective cohortRecording of previous eventsRegulationResearchResearch DesignResearch PersonnelRetrospective StudiesRiskRisk FactorsRisk ReductionRoleSyndromeSystemTestingTrainingTranslational ResearchUnderserved PopulationUnited StatesVascular Cell Adhesion Molecule-1Womanadvanced maternal ageadverse pregnancy outcomeagedbiobankcardiovascular disorder riskcareer developmentendothelial dysfunctionepidemiology studyethnic minority populationhigh riskimprovedlipid metabolismlipidomicsliver injurymalematernal morbiditymaternal outcomemulti-ethnicnewborn adipositynon-alcoholic fatty liver diseasepatient orientedpatient populationpregnancy disorderprepregnancypreventprospectiveracial minority populationreproductiveresearch and developmentsexsystemic inflammatory response
项目摘要
PROJECT SUMMARY
Preeclampsia (PE) is a leading cause of maternal morbidity and mortality in the United States which has led to
an urgent need to accurately predict its risk. It is not known how nonalcoholic fatty liver disease (NAFLD), the
liver manifestation of metabolic syndrome and the most prevalent liver disease among women, contributes to
PE risk. The long-term objective of this proposal is to define the relationship between NAFLD and PE, to
identify strategies to reduce the risk of PE, and to improve short- and long-term maternal outcomes in this
population. This project will evaluate the independent association of NAFLD with PE among overweight and
obese women. It will also study relevant lipid alterations in women with NAFLD in pregnancy which are
associated with endothelial dysfunction that leads to the clinical syndrome of PE, among NAFLD (compared to
non-NAFLD) patients during pregnancy. The Specific Aims of this proposal are: (1) To prospectively assess
whether NAFLD is an independent risk factor for: i) PE among overweight/obese women and ii) PE with liver
injury; (2) To determine whether women with NAFLD in pregnancy have altered levels of bioactive lipids
associated with endothelial cell dysfunction, compared with women without NAFLD in pregnancy. This study
will be performed in the Mount Sinai Health System, which provides care to a diverse and multiethnic patient
population disproportionately affected by both NAFLD and PE. This application will support the candidate's
career development into an independent patient-oriented investigator focused on the influence of liver disease
in pregnancy on preeclampsia risk and future maternal cardiovascular and liver health, a significant unmet
need. The proposed career development plan integrates advanced coursework in translational epidemiology,
lipidomics assessment, prospective study design/ analysis, and biostatistics, and experiential learning through
the conduct of the proposed research plan, all within a highly supportive research environment. The
mentorship team which includes senior investigators with expertise in epidemiologic and translational research
in hepatology (Friedman and Terrault), preeclampsia (Roberts), and prospective study design and advanced
biostatistical analysis (Sigel), will guide the candidate's research and career development. The superb
institutional infrastructure for developing successful clinical investigators and the substantial institutional
commitment to the candidate greatly strengthen this application. At the conclusion of this proposal's funding
period, Dr. Kushner will be optimally positioned as an independent physician-investigator studying the
intersection of liver disease and PE, and their implications on future maternal health.
项目总结
项目成果
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