Mentored Research (K01) Integrative Spatial Epidemiology Study of Wildlife Rabies Spillover

指导研究（K01）野生动物狂犬病溢出的综合空间流行病学研究

• 批准号: 10591846
• 负责人: Luis E Escobar
• 金额: $ 12.64万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-27 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10591846
• 关键词: Achievement; Address; Americas; Animals; Area; Biodiversity; Bioinformatics; Biology; COVID-19; Cattle; Characteristics; Chiroptera; Classification; Climate; Communicable Diseases; Data; Development; Disease; Doctor of Philosophy; Domestic Animals; Ebola; Ecology; Economics; Environmental Risk Factor; Epidemiology; Evolution; Expenditure; Exposure to; Funding; Genetic Structures; Genomics; Geographic Distribution; Geographic Factor; Geographic Locations; Geography; Goals; Habitats; Health; Human; Incidence; Individual; Industry; Infection; Institution; Knowledge; Laboratories; Latin America; Link; Livestock; Machine Learning; Mammals; Measures; Medical; Mentors; Methods; Mexico; Minnesota; Mission; Modeling; Molecular Epidemiology; Nature; Organism; Pattern; Persons; Phylogenetic Analysis; Prevention; Public Health; Rabies; Rabies virus; Recording of previous events; Report (document); Research; Research Personnel; Research Project Grants; Research Proposals; Risk; Role; Shapes; Signal Transduction; Solid; System; Temperature; Testing; Training; United States; United States National Institutes of Health; Universities; Vaccination; Virginia; Virus; Zoonoses; career; disease diagnostic; epidemiology study; genomic data; improved; innovation; insight; machine learning model; mortality; multiple datasets; novel; pathogen; pathogen spillover; post-doctoral training; prevent; previous epidemic; professor; skills; spatial epidemiology; technological innovation; tenure track; transmission process; viral transmission

SUMMARY Synopsis: This is a K01 application by Dr. Luis Escobar, researcher on zoonotic infectious diseases. Escobar’s project Integrative Spatial Epidemiology Study of Wildlife Rabies Spillover will combine spatial modeling with large epidemiological, genomic, and ecological data to investigate pathogen spillover from wildlife to humans and livestock. Candidate: PI Escobar, DVM/MSc/PhD, is a tenure-track Assistant Professor at Virginia Tech, with prior postdoctoral training at SUNY Upstate Medical University and the University of Minnesota and a strong record of scientific achievements. This application has three training objectives to strengthen Escobar’s research as an independent investigator: (1) Training in bioinformatics; (2) Integrate bioinformatics with spatial epidemiology; and (3) Gaining skills in laboratory management and research proposal development to transition to career independence. Mentors: Prof. X.J. Meng, with a solid history of NIH funding, outstanding expertise in bioinformatics, and at the applicant’s institution, will serve as Primary Mentor. Four additional mentors (Drs. Z. Tu, W. Hopkins, S. VandeWoude, A.T. Peterson) will provide complementary expertise and will assess Escobar’s progress towards career independence. Research: Emergent infectious diseases, such as Ebola, Nipah, and COVID-19, have been linked to pathogen spillover from bats to other species. A gap in knowledge exists in the fundamental ecology of pathogen spillover transmission (i.e., Where does it occur and why?), which limits understanding of previous epidemics and capacities to prevent disease emergence. This project will study pathogen spillover from bats to humans and livestock using rabies from the common vampire bat (Desmodus rotundus), a well-documented system of a virus that frequently spills from D. rotundus bats over to other species. While D. rotundus-rabies is restricted to Latin America, it is rapidly expanding towards the United States (US) for unknown reasons. The central hypothesis is that D. rotundus-rabies spillover does not occur randomly in the geography but follows specific biodiversity and habitat patterns, which can be used to predict where pathogen spillover will occur. Aim 1 will determine the role of habitat and virus lineage on rabies-spillover to humans and livestock across Latin America. Aim 2 will identify effect of biodiversity composition on rabies virus spillover transmission. Aim 3 will investigate genomic, geographic, and environmental factors shaping the spread of rabies virus. This hypothesis-driven project has conceptual and technological innovations and combines the expertise of PI Escobar and mentors to illuminate ecological drivers of rabies spillover. Findings will offer new mechanistic insights to explain and anticipate pathogen spillover. As such, this K01 application will facilitate Escobar’ s transition towards research independence and offers exciting discoveries on the ecology of spillover transmission, aligned with the NIH mission to seek fundamental knowledge about the nature of living systems to enhance human health.

总结 简介：这是一个K 01应用程序由路易斯埃斯科瓦尔博士，研究人畜共患传染病。埃斯科瓦尔的计划 野生动物狂犬病溢出的综合空间流行病学研究将联合收割机空间建模与大型 流行病学、基因组和生态学数据，以调查野生动物对人类和牲畜的病原体溢出。 候选人：PI Escobar，DVM/MSc/PhD，是弗吉尼亚理工大学的终身助理教授，具有博士后经验 在纽约州立大学北部医科大学和明尼苏达大学的培训和良好的科学记录， 成绩该应用程序有三个培训目标，以加强Escobar作为独立调查员的研究： (1)生物信息学培训;（2）将生物信息学与空间流行病学相结合;（3）获得实验室技能 管理和研究建议的发展，过渡到职业独立。 导师：X. J. Meng教授，拥有NIH资助的坚实历史，在生物信息学方面的杰出专业知识， 申请人的机构，将担任主要导师。四个额外的导师（博士Z。图，W。霍普金斯，S.范德沃德， A.T.彼得森）将提供补充专业知识，并将评估埃斯科瓦尔的职业独立的进展。 研究：埃博拉、尼帕和COVID-19等突发传染病与病原体溢出有关 从蝙蝠到其他物种。在病原体溢出传播的基本生态学方面存在知识空白（即， 它发生在哪里，为什么？），这限制了对以前流行病的了解和预防疾病的能力 出现。该项目将研究病原体从蝙蝠蔓延到人类和牲畜使用狂犬病从共同 吸血蝙蝠（Desmodus rotundus），一个有据可查的病毒系统，经常从D。圆形蝙蝠 其他物种。而D.狂犬病仅限于拉丁美洲，它正在迅速向美国扩张 (US)原因不明中心假设是D.狂犬病的传播并不是随机发生的， 地理，但遵循特定的生物多样性和栖息地模式，可用于预测病原体溢出将 发生.目标1将确定栖息地和病毒谱系对狂犬病的作用-在拉丁美洲对人类和牲畜的溢出 美国参考目的2探讨生物多样性组成对狂犬病毒外溢传播的影响。Aim 3将进行调查 基因组、地理和环境因素影响狂犬病病毒的传播。这个假设驱动的项目 概念和技术创新，并结合PI Escobar和导师的专业知识， 狂犬病蔓延的驱动因素这些发现将为解释和预测病原体溢出提供新的机制见解。作为 因此，这个K 01应用程序将促进埃斯科瓦尔向研究独立的过渡，并提供令人兴奋的发现 关于溢出传播的生态学，与NIH的使命一致，寻求关于 生活系统，以提高人类健康。