Relationship between prenatal maternal PFAS exposure and child sleep outcomes

产前母亲 PFAS 暴露与儿童睡眠结果之间的关系

• 批准号: 10591251
• 负责人: Sarah Geiger
• 金额: $ 7.93万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-02 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10591251
• 关键词: 4 year old; Academy; Address; Adolescence; Adult; Affect; Age; American; Area; Behavioral; Birth; Blood; Blood Circulation; Characteristics; Chemical Exposure; Child; Child Behavior Checklist; Childhood; Cognitive; Cohort Studies; Complex; Data; Development; Endocrine Disruptors; Environmental Risk Factor; Exposure to; Fetal Development; Fetus; Health; Healthcare; Hormonal; Illinois; Impairment; Individual; Infant; Information Systems; Link; Literature; Measurable; Measurement; Measures; Modeling; Mothers; Nursery Schools; Outcome; Parents; Patient Outcomes Assessments; Pediatrics; Pharmacologic Substance; Plague; Poly-fluoroalkyl substances; Pregnancy; Pregnant Women; Preschool Child; Process; Prospective cohort; Public Health; Reporting; Risk; Sampling; School-Age Population; Serum; Sleep; Sleep Disorders; Sleep disturbances; Statistical Methods; Syndrome; Time; boys; cost; early childhood; environmental chemical; experience; exposed human population; girls; in utero; maternal serum; neurodevelopment; novel; prenatal; prenatal exposure; prospective; sex; sleep health; sleep quality; virtual

About half of US children experience significant sleep issues, according to the American Academy of Pediatrics. Sleep health is critically important to a child’s overall health, including physical, cognitive, and behavioral development. Further, sleep characteristics in childhood can persist into adolescence and then adulthood. It is possible that sleep health may be affected or programmed by factors experienced in utero. Fetal development is sensitive to common environmental chemicals like perfluoroalkyl substances (PFAS), which are highly prevalent among US mothers. PFAS are endocrine disruptors, meaning they can disrupt the body’s normal hormonal processes, crucial to the healthy development of the fetus. It is clear that chemical exposures in pregnant mothers can lead to health problems for their infants that continue into childhood and adolescence. Further, assessments of PFAS-related health outcomes using a mixtures approach are being called for by regulators, given that typical human exposure involves complex combinations of PFAS. In addition, preliminary IKIDS findings indicate a sex-specific association between certain PFAS and sleep disturbance, where boys’ sleep was more affected by PFAS exposure during pregnancy than girls for two specific PFAS in our current sample. The proposed project would use novel statistical methods to assess associations between PFAS exposure during the prenatal period and child sleep quality longitudinally across early childhood, using multiple measures of sleep. PFAS are measured in maternal blood collected at 16-18 weeks’ gestation, and sleep outcomes in young children are measured with three validated parent-report measures capturing different aspects of sleep—disturbance, impairment and sleep problems. We propose to leverage existing data from a prospective cohort of pregnant women and their children based in central Illinois, known as the Illinois Kids Development Study, or IKIDS. Specifically, we will assess the longitudinal effects of prenatal exposure to 12 perfluoroalkyl substances on sleep problems at ages 2, 3, and 4 (aim 1), as well as PFAS mixtures on sleep disturbance, and impairment at age 4 alone (aim 2). Sleep disturbance and sleep impairment are parent-report Patient-Reported Outcomes Measurement Information System (PROMIS) measures and sleep problems is one of the syndrome scales of the preschool Child Behavior Checklist. Child Prenatal PFAS exposure has been shown to be associated with neurodevelopmental outcomes in children, yet there is no literature pertaining to prenatal PFAS effects on sleep quality during early childhood. Both PFAS and child sleep problems are highly prevalent, and preliminary findings show that PFAS exposure in utero may be responsible for some portion of the attributable risk of sleep problems in children. Yet, the area remains vastly understudied. Given that sleep is so crucial to a child’s overall health and development, identifying prevalent and persistent environmental factors that influence sleep health could have a substantial public health impact.

根据美国儿童学会的数据，大约一半的美国儿童有严重的睡眠问题。 儿科.睡眠健康对儿童的整体健康至关重要，包括身体，认知和心理健康。 行为发展此外，儿童时期的睡眠特征可以持续到青春期， 成年睡眠健康可能会受到子宫内经历的因素的影响或编程。 胎儿的发育对常见的环境化学品很敏感，如全氟烷基物质（PFAS）， 这在美国母亲中非常普遍。PFAS是内分泌干扰物，这意味着它们可以破坏 人体正常的荷尔蒙过程，对胎儿的健康发育至关重要。很明显，化学 怀孕母亲的暴露可导致其婴儿的健康问题，并持续到儿童期， 青春期此外，正在使用混合方法评估PFAS相关的健康结果， 这是监管机构要求的，因为典型的人类接触涉及PFAS的复杂组合。在 此外，IKIDS的初步研究结果表明，某些PFAS和睡眠之间存在性别特异性联系 干扰，其中男孩的睡眠在怀孕期间受到PFAS暴露的影响比女孩大两个月。 在我们目前的样本中有特定的PFAS。拟议的项目将使用新的统计方法来评估 产前期间PFAS暴露与儿童睡眠质量之间的相关性 早期儿童，使用多种睡眠测量。在16-18岁时收集的母体血液中测量PFAS 周的怀孕，和睡眠结果在幼儿测量与三个有效的家长报告 测量捕捉睡眠障碍、损害和睡眠问题的不同方面。我们建议 利用来自伊利诺伊州中部孕妇及其子女的前瞻性队列的现有数据， 伊利诺伊州儿童发展研究，简称IKIDS。具体而言，我们将评估以下因素的纵向影响： 产前接触12种全氟烷基物质对2岁、3岁和4岁儿童睡眠问题的影响（目标1），以及 PFAS混合物对睡眠障碍和4岁时的单独损害（目的2）。睡眠障碍与睡眠 损害是父母报告的患者报告结局测量信息系统（PROMIS） 测量和睡眠问题是学龄前儿童行为量表的症状量表之一。孩子 产前PFAS暴露已被证明与儿童的神经发育结果相关，但 目前还没有关于产前PFAS对儿童早期睡眠质量影响的文献。两个PFAS 和儿童睡眠问题非常普遍，初步研究结果表明，在子宫内暴露于PFAS可能 对儿童睡眠问题的部分归因风险负责。然而，该地区仍然 被大大低估了鉴于睡眠对儿童的整体健康和发育至关重要， 影响睡眠健康的普遍和持续的环境因素可能会有大量的公众 健康影响。