Relationship between prenatal maternal PFAS exposure and child sleep outcomes

产前母亲 PFAS 暴露与儿童睡眠结果之间的关系

• 批准号: 10591251
• 负责人: Sarah Geiger
• 金额: $ 7.93万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-02 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10591251
• 关键词: 4 year old; Academy; Address; Adolescence; Adult; Affect; Age; American; Area; Behavioral; Birth; Blood; Blood Circulation; Characteristics; Chemical Exposure; Child; Child Behavior Checklist; Childhood; Cognitive; Cohort Studies; Complex; Data; Development; Endocrine Disruptors; Environmental Risk Factor; Exposure to; Fetal Development; Fetus; Health; Healthcare; Hormonal; Illinois; Impairment; Individual; Infant; Information Systems; Link; Literature; Measurable; Measurement; Measures; Modeling; Mothers; Nursery Schools; Outcome; Parents; Patient Outcomes Assessments; Pediatrics; Pharmacologic Substance; Plague; Poly-fluoroalkyl substances; Pregnancy; Pregnant Women; Preschool Child; Process; Prospective cohort; Public Health; Reporting; Risk; Sampling; School-Age Population; Serum; Sleep; Sleep Disorders; Sleep disturbances; Statistical Methods; Syndrome; Time; boys; cost; early childhood; environmental chemical; experience; exposed human population; girls; in utero; maternal serum; neurodevelopment; novel; prenatal; prenatal exposure; prospective; sex; sleep health; sleep quality; virtual

About half of US children experience significant sleep issues, according to the American Academy of Pediatrics. Sleep health is critically important to a child’s overall health, including physical, cognitive, and behavioral development. Further, sleep characteristics in childhood can persist into adolescence and then adulthood. It is possible that sleep health may be affected or programmed by factors experienced in utero. Fetal development is sensitive to common environmental chemicals like perfluoroalkyl substances (PFAS), which are highly prevalent among US mothers. PFAS are endocrine disruptors, meaning they can disrupt the body’s normal hormonal processes, crucial to the healthy development of the fetus. It is clear that chemical exposures in pregnant mothers can lead to health problems for their infants that continue into childhood and adolescence. Further, assessments of PFAS-related health outcomes using a mixtures approach are being called for by regulators, given that typical human exposure involves complex combinations of PFAS. In addition, preliminary IKIDS findings indicate a sex-specific association between certain PFAS and sleep disturbance, where boys’ sleep was more affected by PFAS exposure during pregnancy than girls for two specific PFAS in our current sample. The proposed project would use novel statistical methods to assess associations between PFAS exposure during the prenatal period and child sleep quality longitudinally across early childhood, using multiple measures of sleep. PFAS are measured in maternal blood collected at 16-18 weeks’ gestation, and sleep outcomes in young children are measured with three validated parent-report measures capturing different aspects of sleep—disturbance, impairment and sleep problems. We propose to leverage existing data from a prospective cohort of pregnant women and their children based in central Illinois, known as the Illinois Kids Development Study, or IKIDS. Specifically, we will assess the longitudinal effects of prenatal exposure to 12 perfluoroalkyl substances on sleep problems at ages 2, 3, and 4 (aim 1), as well as PFAS mixtures on sleep disturbance, and impairment at age 4 alone (aim 2). Sleep disturbance and sleep impairment are parent-report Patient-Reported Outcomes Measurement Information System (PROMIS) measures and sleep problems is one of the syndrome scales of the preschool Child Behavior Checklist. Child Prenatal PFAS exposure has been shown to be associated with neurodevelopmental outcomes in children, yet there is no literature pertaining to prenatal PFAS effects on sleep quality during early childhood. Both PFAS and child sleep problems are highly prevalent, and preliminary findings show that PFAS exposure in utero may be responsible for some portion of the attributable risk of sleep problems in children. Yet, the area remains vastly understudied. Given that sleep is so crucial to a child’s overall health and development, identifying prevalent and persistent environmental factors that influence sleep health could have a substantial public health impact.

根据美国科学院的数据，大约一半的美国儿童经历了严重的睡眠问题 儿科。睡眠健康对儿童的整体健康至关重要，包括身体健康、认知健康和 行为发育。此外，儿童时期的睡眠特征可以持续到青春期，然后 成人期。睡眠健康可能会受到子宫内经历的因素的影响或影响。 胎儿发育对常见的环境化学物质如全氟烷基物质(PFAS)很敏感， 这在美国母亲中非常普遍。全氟辛烷磺酸是内分泌干扰物，这意味着它们可以破坏 身体正常的荷尔蒙过程，对胎儿的健康发育至关重要。很明显，化学物质 孕妇的暴露可能会导致婴儿出现健康问题，并持续到儿童时期和 青春期。此外，正在使用混合办法评估与全氟辛烷磺酸相关的健康结果。 监管机构呼吁，考虑到典型的人体接触涉及复杂的全氟辛烷磺酸组合。在……里面 此外，iKids的初步研究结果表明，某些PFAS与睡眠之间存在特定性别的关联 在怀孕期间，男孩的睡眠受到全氟辛烷磺酸的影响比女孩更大 我们目前样品中的特定全氟辛烷磺酸。拟议的项目将使用新的统计方法来评估 产前接触全氟辛烷磺酸与儿童纵向睡眠质量的关系 儿童早期，使用多种睡眠测量方法。在16-18岁采集的母亲血液中测量全氟辛烷磺酸 用三份有效的父母报告来衡量幼儿的怀孕周和睡眠结果 测量捕捉睡眠障碍、损害和睡眠问题的不同方面。我们建议 利用来自伊利诺伊州中部的一组孕妇及其子女的现有数据， 被称为伊利诺伊州儿童发展研究，或iKids。具体地说，我们将评估 产前暴露于12种全氟烷基物质对2、3和4岁睡眠问题的影响(目标1)，以及 全氟辛烷磺酸混合物治疗睡眠障碍和仅在4岁时的损害(目标2)。睡眠障碍和睡眠 损害是家长报告患者报告结果测量信息系统(PROIS) 措施与睡眠问题是学龄前儿童行为量表的症状量表之一。小孩儿 出生前接触PFAS已被证明与儿童的神经发育结果有关，但 目前还没有关于产前PFAS对儿童早期睡眠质量影响的文献。两个全氟辛烷磺酸 儿童睡眠问题非常普遍，初步研究结果表明，在子宫中接触PFAS可能会 对儿童睡眠问题的某些可归因性风险负有责任。然而，该地区仍然 远远没有得到充分的研究。鉴于睡眠对儿童的整体健康和发展是如此关键，确定 影响睡眠健康的普遍和持久的环境因素可能会有相当大的公众 对健康的影响。