Relationship between prenatal maternal PFAS exposure and child sleep outcomes

产前母亲 PFAS 暴露与儿童睡眠结果之间的关系

• 批准号: 10591251
• 负责人: Sarah Geiger
• 金额: $ 7.93万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-02 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10591251
• 关键词: 4 year old; Academy; Address; Adolescence; Adult; Affect; Age; American; Area; Behavioral; Birth; Blood; Blood Circulation; Characteristics; Chemical Exposure; Child; Child Behavior Checklist; Childhood; Cognitive; Cohort Studies; Complex; Data; Development; Endocrine Disruptors; Environmental Risk Factor; Exposure to; Fetal Development; Fetus; Health; Healthcare; Hormonal; Illinois; Impairment; Individual; Infant; Information Systems; Link; Literature; Measurable; Measurement; Measures; Modeling; Mothers; Nursery Schools; Outcome; Parents; Patient Outcomes Assessments; Pediatrics; Pharmacologic Substance; Plague; Poly-fluoroalkyl substances; Pregnancy; Pregnant Women; Preschool Child; Process; Prospective cohort; Public Health; Reporting; Risk; Sampling; School-Age Population; Serum; Sleep; Sleep Disorders; Sleep disturbances; Statistical Methods; Syndrome; Time; boys; cost; early childhood; environmental chemical; experience; exposed human population; girls; in utero; maternal serum; neurodevelopment; novel; prenatal; prenatal exposure; prospective; sex; sleep health; sleep quality; virtual

About half of US children experience significant sleep issues, according to the American Academy of Pediatrics. Sleep health is critically important to a child’s overall health, including physical, cognitive, and behavioral development. Further, sleep characteristics in childhood can persist into adolescence and then adulthood. It is possible that sleep health may be affected or programmed by factors experienced in utero. Fetal development is sensitive to common environmental chemicals like perfluoroalkyl substances (PFAS), which are highly prevalent among US mothers. PFAS are endocrine disruptors, meaning they can disrupt the body’s normal hormonal processes, crucial to the healthy development of the fetus. It is clear that chemical exposures in pregnant mothers can lead to health problems for their infants that continue into childhood and adolescence. Further, assessments of PFAS-related health outcomes using a mixtures approach are being called for by regulators, given that typical human exposure involves complex combinations of PFAS. In addition, preliminary IKIDS findings indicate a sex-specific association between certain PFAS and sleep disturbance, where boys’ sleep was more affected by PFAS exposure during pregnancy than girls for two specific PFAS in our current sample. The proposed project would use novel statistical methods to assess associations between PFAS exposure during the prenatal period and child sleep quality longitudinally across early childhood, using multiple measures of sleep. PFAS are measured in maternal blood collected at 16-18 weeks’ gestation, and sleep outcomes in young children are measured with three validated parent-report measures capturing different aspects of sleep—disturbance, impairment and sleep problems. We propose to leverage existing data from a prospective cohort of pregnant women and their children based in central Illinois, known as the Illinois Kids Development Study, or IKIDS. Specifically, we will assess the longitudinal effects of prenatal exposure to 12 perfluoroalkyl substances on sleep problems at ages 2, 3, and 4 (aim 1), as well as PFAS mixtures on sleep disturbance, and impairment at age 4 alone (aim 2). Sleep disturbance and sleep impairment are parent-report Patient-Reported Outcomes Measurement Information System (PROMIS) measures and sleep problems is one of the syndrome scales of the preschool Child Behavior Checklist. Child Prenatal PFAS exposure has been shown to be associated with neurodevelopmental outcomes in children, yet there is no literature pertaining to prenatal PFAS effects on sleep quality during early childhood. Both PFAS and child sleep problems are highly prevalent, and preliminary findings show that PFAS exposure in utero may be responsible for some portion of the attributable risk of sleep problems in children. Yet, the area remains vastly understudied. Given that sleep is so crucial to a child’s overall health and development, identifying prevalent and persistent environmental factors that influence sleep health could have a substantial public health impact.

根据美国学院的说法 儿科。睡眠健康对儿童的整体健康至关重要，包括身体，认知和 行为发展。此外，童年的睡眠特征可以持续到青春期，然后 成年。睡眠健康可能会受到子宫中经历的因素的影响或编程。 胎儿发育对普通环境化学物质（如全氟烷基物质（PFA）， 在我们母亲中非常普遍。 PFA是内分泌破坏者，这意味着它们可以破坏 身体正常的马匹过程，对胎儿的健康发育至关重要。很明显化学 怀孕母亲的暴露会导致持续到童年的婴儿的健康问题 青少年。此外，正在使用混合方法评估与PFA相关的健康结果 鉴于典型的人类暴露涉及PFA的复杂组合，因此由调节剂要求。在 此外，初步的IKID发现表明某些PFA和睡眠之间的性别特定关联 骚乱，男孩的睡眠在怀孕期间比女孩更受PFA的影响，而不是两个女孩 我们当前样本中的特定PFA。拟议的项目将使用新颖的统计方法评估 PFA在产前期间暴露与儿童睡眠质量之间的关联 幼儿期，使用多种睡眠措施。 PFA在收集的16-18的母血中测量 几周的妊娠和幼儿的睡眠结果通过三个经过验证的父母报告测量 捕获睡眠不同方面的措施 - 触及障碍，障碍和睡眠问题。我们建议 利用伊利诺伊州中部的孕妇及其子女的现有数据 被称为伊利诺伊州儿童发展研究或ikids。具体而言，我们将评估 在2、3和4岁的睡眠问题上暴露于12种全氟烷基物质（AIM 1）以及 PFA的睡眠障碍混合物和仅在4岁时就损害（AIM 2）。睡眠障碍和睡眠 损伤是父母报告的患者报告结果测量信息系统（PROMIS） 措施和睡眠问题是学龄前儿童行为清单的综合征量表之一。孩子 已显示产前PFAS暴露与儿童的神经发育结果有关 在童年时期，没有与产前PFA对睡眠质量的影响有关的文献。两个PFA 儿童睡眠问题非常普遍，初步发现表明，子宫内的PFA暴露可能 负责儿童睡眠问题的一部分可归因的风险。然而，该地区仍然存在 非常了解。鉴于睡眠对孩子的整体健康和发展至关重要，因此 影响睡眠健康的普遍和持久的环境因素可能会有大量的公众 健康影响。