An automated portable system for detecting and treating opioid induced respiratory depression

用于检测和治疗阿片类药物引起的呼吸抑制的自动化便携式系统

基本信息

  • 批准号:
    10592367
  • 负责人:
  • 金额:
    $ 127.81万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-04-01 至 2025-02-28
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Opioid overdoses caused almost 70,000 deaths in the US in the year ending in November 2020. Many of these occur during the therapeutic use of prescription opioids, particularly when consumption is erratic or among workers from certain professions. Despite the promotion of naloxone for opioid overdose, the effective rescue of an individual from an overdose during the therapeutic use of opioids is still very challenging for several reasons: (1) the onset of an opioid overdose may be very difficult for the patient or their associates to rapidly recognize; (2) the time between the onset of respiratory depression and irreversible brain damage or death is brief; leaving a brief time window to seek medical help and intervene; and (3) methods employed by self- or bystanders to treat an opioid overdose may not be available or are complicated for lay individuals to use. Thus, there is an urgent and unmet need for real-time detection and automated treatment of opioid overdose, even during the therapeutic use of opioids. The overall objective of this U01 application is to develop an automated portable system to detect and treat an opioid overdose in real time. The research team pursues engineering advances in developing wearable sensors for real-time tracking of multiple physiological parameters and therapeutic patches for precise transdermal delivery of naloxone, respectively. The proposed project will further develop wearable sensors to track the variation of physiological parameters (e.g., breathing pattern, blood oxygen level, and heart rate) for the real-time detection of an opioid overdose. The proposed project also aims to optimize novel acoustic patches to deliver naloxone for treating an opioid overdose. A closed-loop system will be established through integration of a wearable sensor, a therapeutic patch, a machine learning-based controller driven by a cell phone. The proposed system will be validated using a mouse model of opioid overdose well developed in the PI’s lab, and adapted for the potential translational applications in human patients. The ultimate product of this study is to construct a prototype system for real-time detection and automated treatment of an opioid overdose.
项目总结

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
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Feng Guo其他文献

Feng Guo的其他文献

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{{ truncateString('Feng Guo', 18)}}的其他基金

An automated portable system for detecting and treating opioid induced respiratory depression
用于检测和治疗阿片类药物引起的呼吸抑制的自动化便携式系统
  • 批准号:
    10478481
  • 财政年份:
    2022
  • 资助金额:
    $ 127.81万
  • 项目类别:
Developing three-dimensional antisense oligonucleotide drugs against COVID-19
开发针对COVID-19的三维反义寡核苷酸药物
  • 批准号:
    10645137
  • 财政年份:
    2021
  • 资助金额:
    $ 127.81万
  • 项目类别:
Developing three-dimensional antisense oligonucleotide drugs against COVID-19
开发针对COVID-19的三维反义寡核苷酸药物
  • 批准号:
    10453620
  • 财政年份:
    2021
  • 资助金额:
    $ 127.81万
  • 项目类别:
Developing three-dimensional antisense oligonucleotide drugs against COVID-19
开发针对COVID-19的三维反义寡核苷酸药物
  • 批准号:
    10280762
  • 财政年份:
    2021
  • 资助金额:
    $ 127.81万
  • 项目类别:
An acoustofluidic avidity cytometer for massive parallel profiling single autoreactive T cell in autoimmune disease
用于大规模平行分析自身免疫性疾病中单个自身反应性 T 细胞的声流控亲和细胞仪
  • 批准号:
    10002377
  • 财政年份:
    2020
  • 资助金额:
    $ 127.81万
  • 项目类别:
Acoustic assembly of patient tumor organoids for modeling cancer immunity
用于模拟癌症免疫的患者肿瘤类器官的声学组装
  • 批准号:
    10187568
  • 财政年份:
    2020
  • 资助金额:
    $ 127.81万
  • 项目类别:
Acoustic assembly of patient tumor organoids for modeling cancer immunity
用于模拟癌症免疫的患者肿瘤类器官的声学组装
  • 批准号:
    10041819
  • 财政年份:
    2020
  • 资助金额:
    $ 127.81万
  • 项目类别:
STRUCTURE OF THE DIMERIZATION DOMAIN OF DIGEORGE CRITICAL REGION 8
DIGEORGE关键区8的二聚化结构域的结构
  • 批准号:
    8361692
  • 财政年份:
    2011
  • 资助金额:
    $ 127.81万
  • 项目类别:
Molecular recognition and regulation in microRNA processing by the DGCR8 protein
DGCR8 蛋白对 microRNA 加工的分子识别和调控
  • 批准号:
    7826938
  • 财政年份:
    2007
  • 资助金额:
    $ 127.81万
  • 项目类别:
Molecular recognition and regulation in microRNA processing by the DGCR8 protein
DGCR8 蛋白对 microRNA 加工的分子识别和调控
  • 批准号:
    7628447
  • 财政年份:
    2007
  • 资助金额:
    $ 127.81万
  • 项目类别:

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