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Core F: Biomarker Core

核心 F：生物标志物核心

基本信息

批准号：
10591558
负责人：
Arnold Bakker
金额：
$ 108.16万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-15 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10591558
关键词：
Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Amyloid beta-Protein Apolipoprotein E Biological Assay Biological Markers Blood Blood specimen Brain imaging Brain scan Cerebrospinal Fluid Clinical Collaborations Collection Communities DNA Data Databases Education Educational Materials Enrollment Functional Magnetic Resonance Imaging Funding Genotype Goals Grant Hippocampus Image MRI Scans Magnetic Resonance Imaging Maps Measures Mentors Methods Mission Participant Peripheral Blood Mononuclear Cell Phase Plasma Positron-Emission Tomography Predisposition Procedures Process Protocols documentation Qualifying Quality Control Research Research Personnel Resolution Resources Rest Scanning Schedule Specimen Thick Training and Education Universities Work brain magnetic resonance imaging interest member novel novel marker participant enrollment repository senior faculty tau Proteins tau-1 training opportunity white matter

项目摘要

BIOMARKER CORE - CORE F: PROJECT SUMMARY/ABSTRACT The Biomarker Core (Core F) of the Johns Hopkins Alzheimer's Disease Research Center (JHADRC) is responsible for collecting and sharing biofluid and imaging data collected from well-characterized participants in the JHADRC, and for making these resources available to investigators working on ADRD at Johns Hopkins University and elsewhere. To accomplish these goals, the Biomarker Core will focus on the following five tasks: (1) to collect and store biospecimens from subjects enrolled in the JHADRC, including blood and cerebrospinal fluid; (2) to acquire and store magnetic resonance imaging scans (MRI) from subjects enrolled in the JHADRC, and to store MRI scans and positron emission tomography (PET) scans acquired in projects associated with the JHADRC; (3) to complete quality control procedures and scan processing on the MRI scans acquired through the JHADRC; (4) to distribute these scans and specimens to qualified investigators both internally and externally, according to established procedures, and; (5) to provide training and educational materials about these biomarkers and their importance in ADRD to researchers and members of the community.

生物标志物核心-核心F：项目摘要/摘要约翰霍普金斯阿尔茨海默病研究中心(JHADRC)的生物标志物核心(核心F)是负责收集和共享从特征良好的参与者那里收集的生物流体和成像数据在JHADRC，并将这些资源提供给在Johns从事ADRD工作的调查人员霍普金斯大学和其他地方。为了实现这些目标，Biomarker核心将专注于以下几个方面五项任务：(1)从JHADRC登记的受试者收集和储存生物检疫试剂，包括血液和脑脊液；(2)获取和存储受试者的磁共振成像扫描(MRI) 在JHADRC中，并存储在项目中获得的核磁共振扫描和正电子发射断层扫描(PET)扫描与JHADRC合作；(3)完成质量控制程序和MRI扫描处理通过JHADRC获得的扫描；(4)将这些扫描和标本分发给合格的调查人员按照既定程序对内对外；(5)提供培训和向研究人员和成员介绍这些生物标志物及其在ADRD中的重要性的教育材料社区。