Visual hallucinations and memory impairment in Parkinson's Disease: The role of hippocampal networks
Visual hallucinations and memory impairment in Parkinson's Disease: The role of hippocampal networks
批准号:
10471165
负责人:
Arnold Bakker
金额:
$61.5万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
未结题
起止时间:
2021-09-01 至 2026-06-30
关键词:
AffectAnimalsAnxietyAreaBradykinesiaBrain imagingBrain regionCaregiver BurdenCharacteristicsClinicalClinical assessmentsCognitiveDataDementiaDevelopmentDiagnosisEpisodic memoryEtiologyExecutive DysfunctionFunctional Magnetic Resonance ImagingFunctional disorderFutureGoalsHallucinationsHigh PrevalenceHippocampus (Brain)HumanHyperactivityImpaired cognitionImpairmentIndividualInterventionLightLinkMeasuresMedialMemoryMemory impairmentMental DepressionMethodsNerve DegenerationNeurobehavioral ManifestationsNeuropsychologyNursing HomesParkinson DiseaseParticipantPatientsPlayPredictive ValueProcessPsychosesPsychotic DisordersQuality of lifeReportingResolutionRestRiskRoleStructureSymptomsTaxesTemporal LobeTestingTremorVisual HallucinationWorkadvanced diseasebasebehavior testcognitive impairment in Parkinson&aposscognitive taskcognitive testingcommon symptomdaily functioningdementia riskdentate gyrusdesigndisabilityepisodic memory impairmentexperiencefollow-upfunctional declinefunctional disabilityhippocampal subregionsimaging biomarkerimaging modalityinsightmemory recallmortalitymotor symptomnetwork dysfunctionneuroimagingneuropsychiatric symptomnon-motor symptomnovel therapeutic interventionnovel therapeuticspatient subsetsprognostic valuepsychiatric symptomvisual memory
中文摘要
项目总结
帕金森氏病(PD)的诊断依据是其特有的运动迟缓症状,
僵硬和震颤。越来越多的神经精神症状被认为是神经退行性疾病的一部分。
帕金森病过程。认知障碍和精神病随着帕金森病的进展而增加,并与
照顾者负担、日常功能受损和养老院安置、痴呆症和更高的死亡率。
具体地说,记忆障碍和幻觉发生在帕金森病患者的一部分中,并与
患痴呆症和功能障碍的风险增加。众所周知,海马体是至关重要的
对记忆功能和海马体功能障碍的重要作用已被证明对
许多人类和动物研究中的记忆障碍。同样,现在人们认识到,海马体
在各种精神障碍的幻觉病因中扮演着重要的角色。然而,它的作用是
帕金森病残留物记忆障碍和幻觉平行临床过程中的海马区网络
不清楚。该项目的目标是评估海马网络功能障碍是否提供了一个共享的
帕金森病患者记忆障碍和幻觉的机制,并确定在特定情况下活动增加是否
海马区预示着更大的认知和功能纵向衰退。
目前的项目旨在通过详细的神经心理评估和高
帕金森病伴情节记忆患者的分辨功能磁共振成像方法
有幻觉的帕金森病患者,没有间歇性记忆障碍或幻觉的帕金森病患者,
和健康的对照组。将采用有针对性的fmri激活任务来对海马区征税。
特定的功能。高分辨率静息状态功能磁共振成像将用于评估
海马区和皮层网络。临床和认知评估将在两年的随访中重复进行
为了评估这些功能磁共振标志物在认知和认知功能障碍进展中的纵向变化和预测价值
帕金森病的功能衰退。
总之,这项拟议的研究将深入了解海马体网络在记忆中的作用
帕金森病的损害和幻觉。这一结果将决定海马亚区功能障碍
是帕金森病患者间歇性记忆损害和幻觉的标志,也是风险增加的预测因子
以应对未来这一亚群患者的下降。最后,如果成功,这项工作将另外提供一个目标
针对帕金森病患者记忆障碍和幻觉的新治疗干预措施的开发。
英文摘要
PROJECT SUMMARY
Parkinson's disease (PD) is diagnosed based on its characteristic motor symptoms of bradykinesia,
rigidity, and tremor. Increasingly, neuropsychiatric symptoms are identified as part of the neurodegenerative
process of PD. Cognitive impairment and psychosis increase as PD advances and are associated with increased
caregiver burden, impaired daily functioning and nursing home placement, dementia, and greater mortality.
Specifically, memory impairment and hallucinations occur in a subset of PD patients and are associated with an
increased risk for dementia and functional impairment. It is well established that the hippocampus is critically
important for memory function and hippocampal dysfunction has been shown to significantly contribute to
memory impairment in numerous human and animal studies. Similarly, it is now recognized that the hippocampus
plays an important role in the etiology of hallucinations across various psychotic disorders. However, the role of
hippocampal networks in the parallel clinical course of memory impairment and hallucinations in PD remains
unclear. The goal of this project is to assess whether hippocampal network dysfunction provides a shared
mechanism for memory impairment and hallucinations in PD and determine whether increased activity in specific
hippocampal subregions predicts greater cognitive and functional decline longitudinally.
The current project aims to achieve these goals using detailed neuropsychological assessment and high-
resolution functional magnetic resonance imaging (fMRI) methods in PD patients with episodic memory
impairment, PD patients with hallucinations, PD patients without episodic memory impairment or hallucinations,
and healthy controls. A targeted fMRI activation task will be employed designed to tax hippocampal subregion
specific functioning. High-resolution resting-state fMRI will be used to assess connectivity changes between
hippocampal and cortical networks. Clinical and cognitive assessments will be repeated at a two-year follow up
to assess longitudinal change and predictive value of these fMRI markers in the progression of cognitive and
functional decline in PD.
Together the proposed studies will provide insight into the role of the hippocampal network in memory
impairment and hallucinations in PD. The results will determine whether dysfunction in hippocampal subregions
is a marker of episodic memory impairment and hallucinations in PD patients and a predictor of increased risk
for future decline in this subset of patients. Finally, if successful, this work would additionally provide a target for
the development of new therapeutic interventions for memory impairment and hallucinations in PD.
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会议论文
Visual hallucinations and memory impairment in Parkinson's Disease: The role of hippocampal networks
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批准号:10668429
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项目类别:
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资助金额:$59.29万
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财政年份:2021
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负责人:Arnold Bakker
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依托单位:
Visual hallucinations and memory impairment in Parkinson's Disease: The role of hippocampal networks
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批准号:10025308
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资助金额:$66.96万
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依托单位:
Core F: Biomarker Core
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批准号:10374078
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项目类别:
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资助金额:$96.51万
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财政年份:2020
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负责人:Arnold Bakker
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依托单位:
Imaging the alpha7 nicotinic acetylcholine receptor in mild cognitive impairment
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Advanced MR Imaging of Olfactory Impairment in Prodromal Alzheimer's Disease
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批准号:10611938
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资助金额:$76.84万
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负责人:Arnold Bakker
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依托单位:
Core F: Biomarker Core
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批准号:10591558
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项目类别:
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资助金额:$108.16万
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负责人:Arnold Bakker
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依托单位:
Imaging the alpha7 nicotinic acetylcholine receptor in mild cognitive impairment
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批准号:10356804
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项目类别:
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资助金额:$76.78万
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财政年份:2020
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负责人:Arnold Bakker
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依托单位:
Advanced MR Imaging of Olfactory Impairment in Prodromal Alzheimer's Disease
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批准号:10377495
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项目类别:
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资助金额:$78.3万
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负责人:Arnold Bakker
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Hippocampal and parietal network changes among subjects in the early phases of AD and relationship with CSF biomarkers
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批准号:9263869
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资助金额:$18.51万
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财政年份:--
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负责人:Arnold Bakker
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依托单位:
Core F: Biomarker Core
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批准号:9921620
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项目类别:
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资助金额:$52.11万
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财政年份:--
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负责人:Arnold Bakker
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依托单位:
Hippocampal and parietal network changes among subjects in the early phases of AD and relationship with CSF biomarkers
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资助金额:$18.56万
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依托单位:
海外基金