A Translational Informatics Framework to Mine Efficacy and Safety of Dietary Supplements

挖掘膳食补充剂功效和安全性的转化信息学框架

• 批准号: 10591302
• 负责人: RUI ZHANG
• 金额: $ 65.53万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2027-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10591302
• 关键词: Adult; Adverse event; Clinic; Clinical; Clinical Research; Complementary Health; Computing Methodologies; Data; Data Set; Data Sources; Disease; Education; Electronic Health Record; Emergency department visit; Food; Foundations; Funding; Goals; Health; Health Personnel; Hospitalization; Informatics; Institution; Integrative Medicine; Knowledge; Link; Literature; Manufacturer; Marketing; Mental Depression; Methods; Mining; National Center for Complementary and Integrative Health; Natural Language Processing; Ontology; Patient risk; Patients; Peer Review; Pharmaceutical Preparations; Publications; Reporting; Research; Resources; Safety; Semantics; Site; Strategic Planning; Surveys; System; Terminology; Translational Research; Treatment Failure; Unified Medical Language System; United States Food and Drug Administration; Work; cohort; data modeling; data repository; dietary supplements; efficacy testing; evidence base; experience; improved; individual patient; informatics tool; innovation; knowledge base; knowledge graph; lexical; multimodal data; novel; nutrition; online resource; open source; post-market; social media; tool

PROJECT SUMMARY Most U.S. adults (77%) take dietary supplements (DS) and 87% of them express overall confidence in the safety, quality and efficacy of DS. However, DS are not always safe. DS information is scattered in biomedical literature, social media, and FDA spontaneous reporting system. Thus, to optimize the proper and safe use of DS, there remains a critical need to develop informatics framework with innovative tools and resources to enable us better understand efficacy and safety of DS through multimodal data sources. Built upon our prior project, the objective of this renewal application is to create an enriched DS knowledge base (eDISK) and to develop a translational informatics framework (iDISK-Mine) with innovative informatics approaches to facility DS research using real-world, multi-site EHR data and. We will expand our prior work in two major aspects: (1) Expand our scope to both efficacy and safety (focus of the prior project) of DS using multimodal data sources to enrich our current DS knowledge base (i.e., eDISK); and (2) Develop and evaluate a translational informatics framework to facilitate DS research using multi-site real world EHR data. We propose the following Specific Aims: (1) Create eDISK by integrating DS efficacy and safety from multimodal data sources; (2) Develop a translational informatics framework (iDISK-Mine) to facilitate EHR-based observational DS research; and (3) Evaluate the generalizability and utility of iDISK-Mine on the multi-site EHR data of depression patients. This is the first project to develop a translational informatics framework to advance our DS knowledge using multimodal data sources and enable us to understand how patients (e.g., depression patients) use DS using the real-world EHR data. The successful accomplishment of this project will deliver a novel framework with valuable tools and resources for DS clinical and translational research.

项目概要 大多数美国成年人 (77%) 服用膳食补充剂 (DS)，其中 87% 的人对膳食补充剂 (DS) 表示总体信心 DS 的安全性、质量和功效。然而，DS 并不总是安全的。 DS信息分散在生物医学领域 文献、社交媒体和 FDA 自发报告系统。因此，为了优化正确和安全的使用 DS，仍然迫切需要开发具有创新工具和资源的信息学框架，以实现 通过多模式数据源，我们更好地了解 DS 的有效性和安全性。基于我们之前的项目， 此更新应用程序的目标是创建丰富的 DS 知识库 (eDISK) 并开发 转化信息学框架 (iDISK-Mine) 具有创新的信息学方法来促进 DS 研究 使用真实世界的多站点 EHR 数据和。我们将从两个主要方面拓展前期工作：（一）拓展我们的前期工作。 使用多模式数据源来丰富 DS 的功效和安全性范围（之前项目的重点） 当前的 DS 知识库（即 eDISK）； (2) 开发和评估翻译信息学框架 使用多站点真实世界 EHR 数据促进 DS 研究。我们提出以下具体目标： (1) 创建 eDISK 通过整合来自多模式数据源的 DS 功效和安全性； (2) 开发翻译 信息学框架（iDISK-Mine），以促进基于 EHR 的观察性 DS 研究； (3) 评估 iDISK-Mine 对抑郁症患者多站点 EHR 数据的普遍性和实用性。这是第一个项目 开发翻译信息学框架，利用多模式数据源提升我们的 DS 知识 并使我们能够利用真实世界的 EHR 数据了解患者（例如抑郁症患者）如何使用 DS。 该项目的成功完成将提供一个具有宝贵工具和资源的新颖框架 用于 DS 临床和转化研究。