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HPV and cancer at multiple anatomic sites

多个解剖部位的 HPV 和癌症

基本信息

批准号：
10919003
负责人：
Aimee Kreimer
金额：
$ 51.24万
依托单位：
DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10919003
关键词：
Address Agreement Anus Biological Cancer Etiology Cervical Cervix Uteri Cutaneous Cytology Data Diagnosis Epidemiology Evaluation Genotype Goals HIV HPV-16/18 Vaccine Head and Neck Cancer Head and Neck Neoplasms Human Human Papilloma Virus-Related Malignant Neoplasm Human Papillomavirus Human papilloma virus infection Human papillomavirus 16 Individual Infection Infection prevention Infectious Agent Larynx Malignant Neoplasms Malignant neoplasm of cervix uteri Multiple Anatomic Sites Natural History Oral Oropharyngeal Population Prevalence Preventive vaccine Recurrent Malignant Neoplasm Research Risk Role Site Skin Specimen Testing Vagina Vulva Work cancer recurrence carcinogenicity cohort conjunctiva efficacy evaluation immunosuppressed malignant mouth neoplasm men oral HPV infection penis prospective sample collection tumor vaccine efficacy vaccine trial

项目摘要

Human papillomaviruses are one of the principal infectious agents known to cause cancers in humans; it is estimated that approximately 5% of cancers worldwide are attributable to HPV infection. HPV-associated cancers occur at particularly high rates among immunosuppressed individuals, especially HIV-infected individuals. While it is well established that HPV is a necessary cause of cervical cancer, world experts agree that for HPV16, the most carcinogenic of the HPV genotypes, data show a causal role in cancers outside the cervix, including the vulva, vagina, penis, and anus, and some head and neck tumors in the oropharynx. Other cancers hypothesized to be related to HPV infection, but for which a causal association has yet to be shown, include cancers of the oral cavity, larynx, conjunctiva, and, for cutaneous HPV types, skin. To that end, considerable research within the IIB focuses on the role of HPV infection in cancer at extra-cervical sites. We have many on-going studies whose aims are to: 1) evaluate the natural history of HPV infections at non-cervical sites 2) determine the prevalence and biologic activity of HPV infection in tumors from these sites 3) assess the prospective association between HPV infection and risk of extra-cervical prevalent, incident, and recurrent cancers 4) evaluate the efficacy of the HPV16/18 prophylactic vaccine against extra-cervical infection

人乳头瘤病毒是已知引起人类癌症的主要传染因子之一;据估计，全世界约5%的癌症可归因于HPV感染。 HPV相关癌症在免疫抑制个体中发生率特别高，尤其是HIV感染个体。虽然HPV是宫颈癌的必要原因，但世界专家一致认为，对于HPV基因型中最致癌的HPV 16，数据显示在宫颈外的癌症中起因果作用，包括外阴，阴道，阴茎和肛门，以及口咽部的一些头颈部肿瘤。其他癌症假设与HPV感染有关，但尚未显示因果关系，包括口腔癌，喉癌，结膜癌，以及皮肤HPV类型的皮肤癌。为此，IIB内部的大量研究集中在HPV感染在宫颈外部位癌症中的作用。我们有许多正在进行的研究，其目的是：1）评估非宫颈部位HPV感染的自然史2）确定这些部位肿瘤中HPV感染的患病率和生物活性3）评估HPV感染与宫颈外流行、事件、4）评估HPV 16/18预防性疫苗对宫颈外感染的有效性

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Proof-of-principle evaluation of the efficacy of fewer than three doses of a bivalent HPV16/18 vaccine.

DOI：
10.1093/jnci/djr319
发表时间：
2011-10-05
期刊：
Journal of the National Cancer Institute
影响因子：
0
作者：
Kreimer AR;Rodriguez AC;Hildesheim A;Herrero R;Porras C;Schiffman M;González P;Solomon D;Jiménez S;Schiller JT;Lowy DR;Quint W;Sherman ME;Schussler J;Wacholder S;CVT Vaccine Group
通讯作者：
CVT Vaccine Group

HPV-associated Oropharyngeal Cancers--Are They Preventable?

HPV相关的口咽癌 - 它们是否可以预防？