STUDY OF PREGNANCY AND NEONATAL HEALTH (SPAN) SPECIMEN REPOSITORY

妊娠和新生儿健康研究（SPAN）样本库

• 批准号: 10927705
• 负责人: BRITTANY MARTIN
• 金额: $ 32.19万
• 依托单位: FISHER BIOSERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-12 至 2026-09-11
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10927705
• 关键词: Acceleration; Affect; African American population; Age; Anthropometry; Attention; Bar Codes; Biological Specimen Banks; Birth; Cardiovascular Diseases; Data; Development; Disease; Ensure; Epigenetic Process; Equipment and supply inventories; Erythrocytes; Fetal Growth; Future; Gene Expression; Genetic; Gestational Age; Hair; Health; Link; Mental disorders; Neonatal; Online Systems; Pathway interactions; Perinatal mortality demographics; Plasma; Pregnant Women; Research; Saliva; Sampling; Seminal fluid; Serum; Services; Specimen; System; Time; Tube; assault; cardiovascular risk factor; delivery complications; father role; fetal; genetic approach; genome wide association study; genomic locus; male; neonatal health; neonatal morbidity; neonatal outcome; neonate; pregnancy health; prenatal; recruit; repository

The timing of delivery (i.e., gestational age) and birth size are important neonatal outcomes for future health, affecting a range of conditions from mental disorders to cardiovascular disease. Research into the Developmental Onset of Health and Disease (DOHaD) evolved upon recognizing that birth size reflects fetal growth. Hence, attention has been paid to the timing of prenatal assaults as well as the type of assault for the resulting birth size, timing of delivery and their intersection (i.e., size for gestational age). More recently, DOHaD and complementary genetic approaches offer opportunities to understand environmental and genetic mechanisms that underpin key pathways important for health and disease. examine critical data gaps motivated by DOHaD, including the father's role, placental determinants, and timing of delivery in relation to neonatal health and development. The SPAN study encompasses three major aims: Aim 1: To determine whether paternal cardiovascular risk factors are associated with fetal growth, neonatal anthropometry, and placental function; and whether semen epigenetic differences explain any of these associations. Aim 2: To conduct a genome-wide association study to identify fetal genetic loci that influence fetal growth and birth anthropometry, and to determine fetal genetic loci associated with placental age acceleration and the functional link between associated genetic loci, placental gene expression and fetal growth in African Americans. Aim 3: To determine the optimal time for GDM complicated deliveries between 37-39 weeks where neonatal morbidity and perinatal mortality is the lowest SPAN will recruit 10,792 pregnant women, their neonates (10,253), and 3825 (~35%) of their male partners.

交付的时间（即，胎龄）和出生大小是新生儿未来健康的重要结果，影响从精神障碍到心血管疾病的一系列疾病。对健康和疾病的发育发作（DOHaD）的研究是在认识到出生大小反映胎儿生长的基础上发展起来的。因此，人们注意到产前攻击的时间以及由此产生的出生大小的攻击类型、分娩时间及其交叉点（即，胎龄大小）。最近，DOHaD和补充遗传方法提供了了解环境和遗传机制的机会，这些机制是关键的 对健康和疾病至关重要的途径。检查由DOHaD驱动的关键数据差距，包括父亲的作用，胎盘决定因素，以及与新生儿健康和发育有关的分娩时间。 SPAN研究包括三个主要目标： 目标1：确定父亲心血管危险因素是否与胎儿生长、新生儿人体测量和胎盘功能相关;以及精液表观遗传差异是否可以解释任何这些关联。 目标二：进行全基因组关联研究，以确定影响胎儿生长和出生人体测量的胎儿遗传基因座，并确定与胎盘年龄加速相关的胎儿遗传基因座以及相关遗传基因座、胎盘基因表达和非裔美国人胎儿生长之间的功能联系。 目标三：为了确定妊娠期糖尿病并发症分娩的最佳时间（37-39周，新生儿发病率和围产期死亡率最低），SPAN将招募10，792名孕妇及其新生儿（10，253）和3，825名（约35%）男性伴侣。