Mechanisms of Staphylococcus aureus virulence

于2023财政年度，我们继续在金黄色葡萄球菌致病机制方面的长期研究。我们的研究的一个重要组成部分是利用动物感染模型来研究致病机制，和/或研究S。金黄色葡萄球菌与人中性粒细胞。虽然大多数细菌容易被嗜中性粒细胞杀死，但一些S.金黄色葡萄球菌已经进化出机制来避免嗜中性粒细胞的破坏，从而引起人类感染。值得注意的是，金黄色葡萄球菌是包括美国在内的世界大部分地区血液、皮肤和软组织以及下呼吸道感染的最常见原因之一。此外，在过去的几十年里，该病原体对抗生素的耐药性越来越强，耐甲氧西林的S。金黄色葡萄球菌（MRSA）是医疗保健相关感染的主要原因。因此，治疗选择有限。

In FY2023, we continued our long-standing research in the area of Staphylococcus aureus pathogenesis. A significant component of our research utilizes animal infection models to study mechanisms of pathogenesis, and/or investigates interaction of S. aureus with human neutrophils. Although most bacteria are killed readily by neutrophils, some strains of S. aureus have evolved mechanisms to circumvent destruction by neutrophils and thereby cause human infections. Notably, Staphylococcus aureus is among the most frequent causes of bloodstream, skin and soft tissue, and lower respiratory tract infections in much of the world, including the United States. In addition, the pathogen has become increasingly resistant to antibiotics over the past several decades and methicillin-resistant S. aureus (MRSA) is a leading cause of healthcare-associated infections. Thus, treatment options are limited.