Mechanisms of Staphylococcus aureus virulence

金黄色葡萄球菌的毒力机制

• 批准号: 10927834
• 负责人: Frank DeLeo
• 金额: $ 70.61万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10927834
• 关键词: Animals; Antibiotic Resistance; Area; Bacteria; Blood Circulation; Development; Diagnostic; Disease; Goals; Human; Infection; Innate Immune Response; Lower Respiratory Tract Infection; Modeling; Multi-Drug Resistance; Pathogenesis; Predisposition; Research; Skin Tissue; Staphylococcus aureus; Staphylococcus aureus infection; Testing; United States; Vancomycin; Virulence; healthcare-associated infections; human disease; methicillin resistant Staphylococcus aureus; neutrophil; pathogen; pathogenic bacteria; prophylactic; soft tissue

In FY2023, we continued our long-standing research in the area of Staphylococcus aureus pathogenesis. A significant component of our research utilizes animal infection models to study mechanisms of pathogenesis, and/or investigates interaction of S. aureus with human neutrophils. Although most bacteria are killed readily by neutrophils, some strains of S. aureus have evolved mechanisms to circumvent destruction by neutrophils and thereby cause human infections. Notably, Staphylococcus aureus is among the most frequent causes of bloodstream, skin and soft tissue, and lower respiratory tract infections in much of the world, including the United States. In addition, the pathogen has become increasingly resistant to antibiotics over the past several decades and methicillin-resistant S. aureus (MRSA) is a leading cause of healthcare-associated infections. Thus, treatment options are limited.

2023 财年，我们继续在金黄色葡萄球菌发病机制领域进行长期研究。我们研究的一个重要组成部分是利用动物感染模型来研究发病机制，和/或研究金黄色葡萄球菌与人类中性粒细胞的相互作用。尽管大多数细菌很容易被中性粒细胞杀死，但一些金黄色葡萄球菌菌株已经进化出机制来规避中性粒细胞的破坏，从而引起人类感染。值得注意的是，在包括美国在内的世界大部分地区，金黄色葡萄球菌是导致血液、皮肤和软组织以及下呼吸道感染的最常见原因之一。此外，在过去的几十年里，病原体对抗生素的耐药性越来越强，耐甲氧西林金黄色葡萄球菌 (MRSA) 是医疗保健相关感染的主要原因。因此，治疗选择是有限的。

项目成果

Community-associated methicillin-resistant Staphylococcus aureus and athletes.

社区相关的耐甲氧西林金黄色葡萄球菌和运动员。

• DOI: 10.3810/psm.2012.05.1960
• 发表时间: 2012
• 期刊: The Physician and sportsmedicine
• 作者: Malachowa,Natalia;Kobayashi,ScottD;DeLeo,FrankR
• 通讯作者: DeLeo,FrankR

Staphylococcus aureus protein A promotes immune suppression.

• DOI: 10.1128/mbio.00764-13
• 发表时间: 2013-10-01
• 期刊: mBio
• 影响因子: 6.4
• 作者: Kobayashi SD;DeLeo FR
• 通讯作者: DeLeo FR

Staphylococcus aureus leukotoxin GH promotes formation of neutrophil extracellular traps.

• DOI: 10.4049/jimmunol.1301821
• 发表时间: 2013-12-15
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Malachowa N;Kobayashi SD;Freedman B;Dorward DW;DeLeo FR
• 通讯作者: DeLeo FR

Insights into the Staphylococcus aureus-host interface: global changes in host and pathogen gene expression in a rabbit skin infection model.

• DOI: 10.1371/journal.pone.0117713
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Malachowa N;Kobayashi SD;Sturdevant DE;Scott DP;DeLeo FR
• 通讯作者: DeLeo FR

Inflammation in 3D.

3D 炎症。

• DOI: 10.1016/j.chom.2012.05.006
• 发表时间: 2012
• 期刊: Cell host & microbe
• 影响因子: 30.3
• 作者: Kobayashi,ScottD;DeLeo,FrankR
• 通讯作者: DeLeo,FrankR