Mechanisms of community MRSA virulence

社区 MRSA 毒力机制

基本信息

项目摘要

In FY2017, we continued to investigate how Staphylococcus aureus causes disease. Although most bacteria are killed readily by PMNs, some strains of S. aureus have evolved mechanisms to circumvent destruction by neutrophils and thereby cause human infections. Notably, Staphylococcus aureus is among the most frequent causes of bloodstream, skin and soft tissue, and lower respiratory tract infections in much of the world, including the United States. In addition, the pathogen has become increasingly resistant to antibiotics over the past several decades and methicillin-resistant S. aureus (MRSA) is a leading cause of healthcare-associated infections. Thus, treatment options are limited. Healthcare-associated MRSA infections are typical of individuals with predisposing risk factors. In contrast, community-associated MRSA (CA-MRSA) cause disease in otherwise healthy individuals, and these infections can be severe or fatal. CA-MRSA emerged in the 1990s and then spread worldwide over the next decade. Although there has been a recent decrease in the number of hospital MRSA infections, the level of CA-MRSA infections has remained relatively constant. The molecular basis for the increased virulence potential and success of CA-MRSA strains is incompletely defined. Thus, a significant component of the Section is directed to address this deficiency in knowledge. Other ongoing studies investigated the interaction of S. aureus with components of the human immune system, and the ability of influenza A virus to alter the response of neutrophils to S. aureus.
于2017财政年度,我们继续研究金黄色葡萄球菌如何致病。尽管大多数细菌很容易被中性粒细胞杀死,但一些S.金黄色葡萄球菌已经进化出机制来避免嗜中性粒细胞的破坏,从而引起人类感染。值得注意的是,金黄色葡萄球菌是包括美国在内的世界大部分地区血液、皮肤和软组织以及下呼吸道感染的最常见原因之一。此外,在过去的几十年里,该病原体对抗生素的耐药性越来越强,耐甲氧西林的S。金黄色葡萄球菌(MRSA)是医疗保健相关感染的主要原因。因此,治疗选择有限。医疗保健相关的MRSA感染是具有易感风险因素的典型个体。相比之下,社区相关MRSA(CA-MRSA)在其他健康个体中引起疾病,这些感染可能是严重的或致命的。CA-MRSA出现于20世纪90年代,然后在接下来的十年中在全球范围内传播。虽然最近医院MRSA感染的数量有所减少,但CA-MRSA感染的水平保持相对稳定。CA-MRSA菌株的毒力潜力增加和成功的分子基础尚未完全确定。 因此,该科的一个重要组成部分是针对解决这一知识不足的问题。 其他正在进行的研究调查了S。金黄色葡萄球菌与人类免疫系统的组分,以及甲型流感病毒改变中性粒细胞对金黄色葡萄球菌的反应的能力。金黄色。

项目成果

期刊论文数量(0)
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Frank DeLeo其他文献

Frank DeLeo的其他文献

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{{ truncateString('Frank DeLeo', 18)}}的其他基金

Interaction of pathogenic bacteria with human phagocytic leukocytes
致病菌与人类吞噬白细胞的相互作用
  • 批准号:
    9161537
  • 财政年份:
  • 资助金额:
    $ 61.29万
  • 项目类别:
Mechanisms of Staphylococcus aureus virulence
金黄色葡萄球菌的毒力机制
  • 批准号:
    10927834
  • 财政年份:
  • 资助金额:
    $ 61.29万
  • 项目类别:
Mechanisms of community MRSA virulence
社区 MRSA 毒力机制
  • 批准号:
    10272151
  • 财政年份:
  • 资助金额:
    $ 61.29万
  • 项目类别:
Interaction of pathogenic bacteria with human phagocytic leukocytes
致病菌与人类吞噬白细胞的相互作用
  • 批准号:
    8745391
  • 财政年份:
  • 资助金额:
    $ 61.29万
  • 项目类别:
Interaction of pathogenic bacteria with human phagocytic leukocytes
致病菌与人类吞噬白细胞的相互作用
  • 批准号:
    8336155
  • 财政年份:
  • 资助金额:
    $ 61.29万
  • 项目类别:
Mechanisms of community MRSA virulence
社区 MRSA 毒力机制
  • 批准号:
    8336290
  • 财政年份:
  • 资助金额:
    $ 61.29万
  • 项目类别:
Mechanisms of community MRSA virulence
社区 MRSA 毒力机制
  • 批准号:
    8555989
  • 财政年份:
  • 资助金额:
    $ 61.29万
  • 项目类别:
Basis for Success of Multidrug-Resistant Enterobacteriaceae
多重耐药肠杆菌科细菌的成功基础
  • 批准号:
    9354929
  • 财政年份:
  • 资助金额:
    $ 61.29万
  • 项目类别:
Mechanisms of community MRSA virulence
社区 MRSA 毒力机制
  • 批准号:
    7732727
  • 财政年份:
  • 资助金额:
    $ 61.29万
  • 项目类别:
Interaction of pathogenic bacteria with human phagocytic leukocytes
致病菌与人类吞噬白细胞的相互作用
  • 批准号:
    10014089
  • 财政年份:
  • 资助金额:
    $ 61.29万
  • 项目类别:

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抗生素耐药性在细菌-质粒网络中的传播
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细菌抗生素抗性基因转移 DNA 加工的分子机制
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任务E13:抗生素耐药性细菌介入制剂的开发
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    10933758
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Southeast Center for Agricultural Health and Injury Prevention: Enteric bacteria, antibiotic resistance and farm worker health on livestock farms
东南部农业健康与伤害预防中心:畜牧场的肠道细菌、抗生素耐药性和农场工人健康
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SBIR 第一阶段:快速检测血源性细菌并确定抗生素耐药性
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