剖腹产新生儿的阴道微生物群播种和健康结果：一项随机对照试验-猫眼课题宝

剖腹产新生儿的阴道微生物群播种和健康结果：一项随机对照试验

批准号：

10927996

负责人：

Suchitra Hourigan

金额：

$167.3万

依托单位：

NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/10927996

关键词：

2 year old 3 year old Adverse event Animal Model Birth Body mass index COVID-19 Cesarean section Child Health Clinical Clinical Research Clinical Trials Data Data Collection Development Disease Electronic Health Record Engraftment Enrollment Exposure to Feces Health Health protection Immune Immune System Diseases Infant Inflammatory Intervention Life Link Mediating Metabolic Metabolic Diseases Methods Microbe Mothers Newborn Infant Obesity Operative Surgical Procedures Oral cavity Outcome Outcome Measure Persons Pilot Projects Procedures Randomized Randomized, Controlled Trials Regulation Research Personnel Safety Site Skin Structure Surveys Swab Testing Vagina Visit arm beneficial microorganism experimental arm follow-up gut microbiota health of the mother high risk immune health insight maternal microbiome microbiome microbiome analysis neonate normal microbiota obesity risk offspring phase 1 study phase 2 study primary outcome restoration sample collection secondary outcome skin microbiota treatment arm vaginal microbiome vaginal microbiota

项目摘要

项目成果

Suchitra Hourigan的其他基金

相似基金

相关文献

中文摘要

翻译

点击翻译按钮获取中文摘要

英文摘要

During the Fiscal Year 2023, the clinical trial continued enrollment after a 2 year pause due to Covid-19. Many mothers have been enrolled and randomized, with infants being followed up to 3 years of age with serial data and sample collection points. Initial early life microbiome data between treatment arms has been analyzed and shows a difference in microbiome structure and composition between treatment arms and that vaginal seeding causes engraftment of the maternal microbiome in multiple infant body sites. Animal models of vaginal seeding to gain further mechanistic insight have commenced.

期刊论文(0)

专著(0)

科研奖励(0)

会议论文