The contribution of antibiotic exposure in the prenatal, peripartum and infancy period to intestinal microbiome perturbations and association with early childhood obesity.

产前、围产期和婴儿期抗生素暴露对肠道微生物群扰动的影响以及与儿童早期肥胖的关系。

基本信息

  • 批准号:
    10188584
  • 负责人:
  • 金额:
    $ 15.88万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-07-23 至 2021-08-29
  • 项目状态:
    已结题

项目摘要

The research program proposed herein is to support the development of Suchitra Hourigan, MD, into an independent investigator aiming to conduct novel and transformative research into the role of gut microbiome development in early childhood health and disease, with a focus on obesity. She seeks a K23 award in order to obtain the skill set, knowledge, formalized training and mentored research experience critical for her transition from an early career physician-scientist with a solid foundation in the basics of trial design, recruitment, epidemiology and microbiome analysis to an independent scientist who conducts trials designed to intervene on microbial communities that contribute to childhood disease. Two essential components of her transition into research independence are hands-on mentored training in 1) the conduct and design of trials and translational microbiome studies and 2) the interpretation of longitudinal microbiome analysis combined with rich epidemiological data. The proposed K23 Career Development plan will accomplish these goals. Obesity is a worldwide epidemic. There is a critical window in very early life that is conjectured to be predictive of later obesity risk, in part due to the establishment of the gut microbiome and metabolic programming that occur. Epidemiological studies have indicated that early exposure to antibiotics increases the risk of childhood obesity. It is hypothesized that early antibiotic exposure causes detrimental gut microbiota perturbations that ‘program’ the host to an obesity-prone metabolic phenotype which persists after discontinuation of antibiotics; however this has never been shown in humans. To test this hypothesis, prospective longitudinal studies with microbiome analysis are needed. The overall goal of this project is to determine the relative contributions of antibiotic exposure in the prenatal, peripartum and infancy period to intestinal microbiome perturbations and association with early childhood obesity. This will be achieved by leveraging the infrastructure of the unique established longitudinal cohort study at Inova (NIH-NICHD ECHO 4UH3OD023337-03). Dr. Hourigan will carry out this proposal in the rich research environment of the Inova Translational Medicine Institute with additional training at the Johns Hopkins School of Medicine where she remains a faculty member. Under the collaborative and supportive mentorship of her primary mentor Dr. John Niederhuber, MD (Executive Vice President of the Inova Health System and CEO of the Genomics and Bioinformatics Research Institute at Inova), co-mentor Dr. Cynthia Sears, MD (Professor of Medicine in the Division of Infectious Disease and Gastroenterology, Johns Hopkins) and advisors, she is well positioned to complete the proposed activities. In addition to leading this research, Dr. Hourigan will attend courses, workshops, scientific meetings and participate in weekly study activities with her mentors. This mentored training will enable Dr. Hourigan to grow into an independent researcher, with expertise in the design, conduct and analysis of longitudinal microbiome studies, focused on understanding role of the developing gut microbiome in childhood health outcomes.
本文提出的研究计划旨在支持Suchitra Hourigan医学博士的发展

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
An ambient-temperature storage and stabilization device performs comparably to flash-frozen collection for stool metabolomics in infants.
  • DOI:
    10.1186/s12866-021-02104-6
  • 发表时间:
    2021-02-22
  • 期刊:
  • 影响因子:
    4.2
  • 作者:
    Ramamoorthy S;Levy S;Mohamed M;Abdelghani A;Evans AM;Miller LAD;Mehta L;Moore S;Freinkman E;Hourigan SK
  • 通讯作者:
    Hourigan SK
Epidemiological and microbiome associations of Clostridioides difficile carriage in infancy and early childhood.
  • DOI:
    10.1080/19490976.2023.2203969
  • 发表时间:
    2023-01
  • 期刊:
  • 影响因子:
    12.2
  • 作者:
  • 通讯作者:
Differences in maternal gene expression in Cesarean section delivery compared with vaginal delivery.
  • DOI:
    10.1038/s41598-020-74989-8
  • 发表时间:
    2020-10-20
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Kothiyal P;Schulkers K;Liu X;Hazrati S;Vilboux T;Gomez LM;Huddleston K;Wong WSW;Niederhuber JE;Conrads TP;Maxwell GL;Hourigan SK
  • 通讯作者:
    Hourigan SK
Updates and Challenges in Fecal Microbiota Transplantation for Clostridioides difficile Infection in Children.
Gut microbial composition difference between pediatric ALL survivors and siblings.
  • DOI:
    10.1080/08880018.2020.1759740
  • 发表时间:
    2020-09
  • 期刊:
  • 影响因子:
    1.7
  • 作者:
    Thomas R;Wong WSW;Saadon R;Vilboux T;Deeken J;Niederhuber J;Hourigan SK;Yang E
  • 通讯作者:
    Yang E
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Suchitra Hourigan其他文献

Suchitra Hourigan的其他文献

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{{ truncateString('Suchitra Hourigan', 18)}}的其他基金

The contribution of antibiotic exposure in the prenatal, peripartum and infancy period to intestinal microbiome perturbations and association with early childhood obesity.
产前、围产期和婴儿期抗生素暴露对肠道微生物群扰动的影响以及与儿童早期肥胖的关系。
  • 批准号:
    9804986
  • 财政年份:
    2019
  • 资助金额:
    $ 15.88万
  • 项目类别:
The contribution of antibiotic exposure in the prenatal, peripartum and infancy period to intestinal microbiome perturbations and association with early childhood obesity.
产前、围产期和婴儿期抗生素暴露对肠道微生物群扰动的影响以及与儿童早期肥胖的关系。
  • 批准号:
    9982366
  • 财政年份:
    2019
  • 资助金额:
    $ 15.88万
  • 项目类别:
A pilot study of fecal microbiota transplantation for Chronic Granulomatous Disorder Associated Colitis (CGD-AC)
粪便微生物群移植治疗慢性肉芽肿性疾病相关结肠炎 (CGD-AC) 的初步研究
  • 批准号:
    10927992
  • 财政年份:
  • 资助金额:
    $ 15.88万
  • 项目类别:
Vaginal microbiome seeding and health outcomes in Cesarean-delivered neonates: a randomized controlled trial
剖腹产新生儿的阴道微生物群播种和健康结果:一项随机对照试验
  • 批准号:
    10927996
  • 财政年份:
  • 资助金额:
    $ 15.88万
  • 项目类别:
The role of the microbiome in childhood disease
微生物组在儿童疾病中的作用
  • 批准号:
    10927997
  • 财政年份:
  • 资助金额:
    $ 15.88万
  • 项目类别:

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