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Multi-racial genetic analysis of hidradenitis suppurativa

化脓性汗腺炎的多种族遗传分析

基本信息

批准号：
10930260
负责人：
Wilson Liao
金额：
$ 9.34万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-16 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10930260
关键词：
Abscess Academia Acceleration Address Affect African American African American population African ancestry American Architecture Asian Asian ancestry Asian population Atopic Dermatitis Bioinformatics Biological Biological Assay Buttocks Cell Communication Cells Chinese Clinical Data Collaborations Cytometry DNA Data Data Set Deposition Development Disease Emotional Ethnic Origin Europe European European ancestry Exhibits FDA approved Foundations Future Genetic Genetic Risk Genetic study Genotype Grant Hidradenitis Suppurativa Immune Immunobiology Immunologist Individual Inflammatory Inguinal region International Knowledge Latino Population Link Luciferases Lupus Mediating Meta-Analysis Methods Minority Morbidity - disease rate Nodule North America Outcome Pathogenesis Pathway interactions Patients Phenotype Population Predisposition Prevalence Proteomics Psoriasis Publications Publishing Race Registries Reporter Research Personnel Resources Risk Sampling Sarcoidosis Severities Sinus Skin Suspensions Taiwan Untranslated RNA Variant Work admixture mapping case control cell type cohort comorbidity database of Genotypes and Phenotypes deep sequencing effective therapy genetic analysis genetic architecture genetic risk factor genetic variant genome wide association study genome-wide genomic locus immunopathology innovation insight meetings multi-racial novel novel therapeutics racial difference racial disparity racial diversity racial population single-cell RNA sequencing skin barrier skin disorder therapeutic target transcriptome transcriptomics treatment response

项目摘要

Project summary Hidradenitis suppurativa (HS) is an underrecognized common, immune-mediated skin disease characterized by inflammatory nodules, abscesses, and sinus tracts in the groin, buttocks, and axillae leading to devasting physical and emotional morbidity. HS significantly affects European Americans and minorities such as African-Americans, Asians, and Latinos. Treatments for HS are poor, with only a single FDA-approved therapy available. The paucity of treatments is driven by a profound lack of understanding of HS pathogenesis, particularly with respect to the genetic pathways involved. In this application, we utilize a variety of innovative approaches to address this significant gap. First, we perform a genome-wide association study (GWAS) in European, African American, and Asian HS cases and healthy controls. Second, we perform trans-ethnic genome wide meta-analysis to identify shared and distinct genetic risk factors. Third, we will perform multi-racial spatial transcriptomics and proteomics of HS skin to elucidate cell-cell interactions, and further identify causal GWAS variants through luciferase reporter assays. Together, these studies will advance our knowledge of the genetic architecture and immunobiology of HS in different racial populations and identify new biologic pathways that can be therapeutically targeted.

项目总结