Remote Exposome Monitoring for Skin Diseases through Digital Health Devices and Home-Based Multiomics

通过数字健康设备和家庭多组学对皮肤病进行远程暴露监测

• 批准号: 10871108
• 负责人: Wilson Liao
• 金额: $ 44.41万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10871108
• 关键词: Academic Medical Centers; Acceleration; Adverse event; Air; Air Pollution; Allergens; Ambrosia; Apple watch; Atopic Dermatitis; Autoimmune; Biological; Biological Assay; Biological Markers; Biometry; Blood; Blood capillaries; Blood specimen; California; Cells; Clinical Research; Collaborations; Collection; Consumption; Data; Data Collection; Dermatology; Devices; Disease; Enrollment; Environmental Exposure; Environmental Monitoring; Environmental Risk Factor; Epigenetic Process; Exercise; Exposure to; Flare; Future; Generations; Genetic; Geography; Grant; HIV Infections; Health; Heart Rate; Home; Human; Humidity; Immune; Individual; Inflammatory; Measurement; Measures; Mediating; Medicine; Methods; Molds; Monitor; National Institute of Arthritis, and Musculoskeletal, and Skin Diseases; Needles; Office Visits; Painless; Participant; Patients; Persons; Pharmaceutical Preparations; Phenotype; Play; Poaceae; Procedures; Proteomics; Psoriasis; Publishing; Quality of life; Race; Recommendation; Research; Research Personnel; Resources; Role; Sampling; Severities; Skin; Sleep; Smoking; Soil; Staphylococcus aureus; Streptococcal Infections; Stress; Study Subject; Symptoms; Temperature; Time; Travel; Trees; Ultraviolet Rays; Venipunctures; Visit; Wildfire; Work; acceptability and feasibility; analytical method; biomarker identification; cohort; digital health; indexing; innovation; microbiome research; mobile application; multiple omics; new technology; novel; patient engagement; peripheral blood; quality assurance; remote monitoring; response; single-cell RNA sequencing; skin disorder; socioeconomics; temporal measurement; tool; transcriptomics; translational study; wearable device

Project Summary The exposome, defined as the measure of all exposures for an individual and how those exposures relate to an individual's health, plays a key role in many immune-mediated inflammatory skin diseases. Measuring the exposome over time and understanding its effect on human health using sophisticated readouts such as - omics assays is a key priority for future clinical and translational studies. However, one of the major barriers to conducting such longitudinal exposome studies is their frequent reliance on in-person clinical research visits. In-person research visits, often requiring time-consuming travel to an academic medical center and absence from work, can significantly limit the geographic, racial, and socioeconomic representation of research participants. These in-person visits also typically occur every few months, limiting the temporal resolution of exposome data that can be measured. This proposal focuses on the implementation of innovative strategies for remote, home-based exposome monitoring and -omics measurements. Successful completion of this work will provide valuable resources for a future collaborative network studying the exposome.

项目摘要 曝光组，定义为衡量个人的所有曝光量以及这些曝光量如何与 一个人的健康，在许多免疫介导的炎症性皮肤病中起着关键作用。测量 使用复杂的读数，如： 组学分析是未来临床和翻译研究的关键优先事项。然而，主要的障碍之一是 进行这样的纵向暴露研究是他们经常依赖于面对面的临床研究访问。 面对面的研究访问，通常需要到学术医疗中心进行耗时的旅行和缺席 在工作中，可能会显著限制研究的地理、种族和社会经济代表性 参与者。这些面对面的访问通常每隔几个月进行一次，限制了 曝光可以测量的数据。这项建议侧重于实施创新战略 用于远程、基于家庭的曝光组监测和组学测量。圆满完成这项工作 将为未来研究曝光组的协作网络提供宝贵的资源。