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NATIONAL FERRET RESOURCE AND RESEARCH CENTER ON LUNG DISEASE

国家雪貂肺病资源与研究中心

基本信息

批准号：
10929919
负责人：
JESSICA BOYLE
金额：
$ 113.19万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-23 至 2024-09-22
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10929919
关键词：
Advisory Committees Age Alveolar Cell Animal Model Animals Anti-Inflammatory Agents Antibodies Biological Biology Body Fluids Catalogs Cell Therapy Cells Communities Complementary DNA Contracts Cystic Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator Data Databases Decision Making Deposition Development Disease Disease model Educational workshop Enzyme-Linked Immunosorbent Assay Farm Ferrets Fluorescence-Activated Cell Sorting Foundations Funding Gene Expression Genes Genetic Genetic Engineering Genetically Modified Animals Genotype Gland Goals Grant Human Human Resources Immunoprecipitation In Situ Hybridization Industrialization International Knock-in Knock-out Leadership Left Lung Lung diseases Maps Messenger RNA Methods Modeling Mus National Heart, Lung, and Blood Institute Phenotype Preparation Protocols documentation Pulmonary function tests RNA Reagent Records Research Research Contracts Research Personnel Resources Sampling Site Source Specimen Submucosa Technology Testing Therapeutic Agents Tissue Model Tissue Sample Tissues Trachea Training Transgenic Organisms United States Department of Agriculture United States National Institutes of Health Western Blotting Work Xenograft procedure cell type experimental study material transfer agreement member pharmacologic programs recombinant virus repository sample collection single-cell RNA sequencing stem cell biology stem cell therapy stem cells symposium therapeutic evaluation web site

项目摘要

During the proposed funding period, the NFLRRC seeks to facilitate the utilization of ferret models for lung disease by generating genetically modified animals, biological specimens, reagents, and data easily accessible, and by expanding the genetic toolbox for ferret-based research on lung biology. Our work will focus on three objectives: 1) Distribute ferrets, and biologic specimens from ferrets, for the study of lung disease and lung biology and for the testing of therapeutics; 2) Generate additional genetic ferret models relevant to lung disease and lung biology; and 3) Maintain and build a repository of reagents and information needed for ferret research. The expected accomplishments of establishing the proposed NFLRRC are facilitation (at both the technical and fiscal levels) of the utilization of ferret models in the study of lung disease, for which other animal models are not well suited. This undertaking has had, and will continue to have, a broad impact on our understanding of diseases for which other animal models have failed to accurately recapitulate the human phenotypes.

在建议的资助期内，NFLRRC寻求促进使用雪貂模型进行肺通过容易地产生转基因动物、生物标本、试剂和数据，并通过扩大基于雪貂的肺部生物学研究的遗传工具箱。我们的工作将集中在有三个目标：1）分发雪貂和雪貂的生物标本，用于肺部疾病和肺部疾病的研究。这些研究包括：（1）建立雪貂研究所需的基因库，用于研究雪貂的肺部疾病和肺部生物学以及治疗方法的测试;（2）生成与肺部疾病和肺部生物学相关的其他雪貂遗传模型;以及（3）维护和建立雪貂研究所需的试剂和信息库。建立拟议的国家森林资源恢复和复原中心的预期成果是促进（技术和和财政水平）的雪貂模型在肺部疾病的研究中的利用，其他动物模型并不适合。这项工作已经并将继续对我们的理解产生广泛影响其他动物模型无法准确再现人类表型的疾病。