NATIONAL FERRET RESOURCE AND RESEARCH CENTER ON LUNG DISEASE

在建议的资助期内，NFLRRC寻求促进使用雪貂模型进行肺 通过容易地产生转基因动物、生物标本、试剂和数据， 并通过扩大基于雪貂的肺部生物学研究的遗传工具箱。我们的工作将集中在 有三个目标：1）分发雪貂和雪貂的生物标本，用于肺部疾病和肺部疾病的研究。 这些研究包括：（1）建立雪貂研究所需的基因库，用于研究雪貂的肺部疾病和肺部生物学以及治疗方法的测试;（2）生成与肺部疾病和肺部生物学相关的其他雪貂遗传模型;以及（3）维护和建立雪貂研究所需的试剂和信息库。建立拟议的国家森林资源恢复和复原中心的预期成果是促进（技术和 和财政水平）的雪貂模型在肺部疾病的研究中的利用，其他动物模型 并不适合。这项工作已经并将继续对我们的理解产生广泛影响 其他动物模型无法准确再现人类表型的疾病。

During the proposed funding period, the NFLRRC seeks to facilitate the utilization of ferret models for lung disease by generating genetically modified animals, biological specimens, reagents, and data easily accessible, and by expanding the genetic toolbox for ferret-based research on lung biology. Our work will focus on three objectives: 1) Distribute ferrets, and biologic specimens from ferrets, for the study of lung disease and lung biology and for the testing of therapeutics; 2) Generate additional genetic ferret models relevant to lung disease and lung biology; and 3) Maintain and build a repository of reagents and information needed for ferret research. The expected accomplishments of establishing the proposed NFLRRC are facilitation (at both the technical and fiscal levels) of the utilization of ferret models in the study of lung disease, for which other animal models are not well suited. This undertaking has had, and will continue to have, a broad impact on our understanding of diseases for which other animal models have failed to accurately recapitulate the human phenotypes.