The complosome in meningeal health and disease

在感染和多发性硬化症等神经炎性疾病期间，脑膜免疫细胞中的细胞内和/或细胞自主补体的作用完全未被探索。因此，这是我们刚刚开始的一个全新的研究领域。我们现在已经产生了独特的小鼠品系，在特定的脑细胞中特异性地缺失了选择的补体基因，目前正在ms小鼠模型中评估这些。我们特别针对C5系统，因为我们已经产生了一个固定的C5报告小鼠品系。实验还将结合C5靶向肽的体内应用等。

The role of intracellular and/or cell-autonomous complement in immune cells in the meninges during infection and during neuro-inflammatory disease such as multiple sclerosis is completely unexplored. Thus, this is an entirely new research area which we have just started. We have now generated unique mouse strains with specific deletion of selected complement genes in specific brain cells and are currently assessing these in mouse models of MS. We are targeting specifically the C5 system because we have generated a floxed C5 reporter mouse line. Experiments will also be combined in the future with the in vivo application of C5 targeting peptides, etc.