The complosome in meningeal health and disease

脑膜健康和疾病中的复合体

• 批准号: 10929206
• 负责人: Claudia Kemper
• 金额: $ 60.68万
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10929206
• 关键词: Area; Brain; Cells; Complement; Disease; Future; Health; Immune; Infection; LoxP-flanked allele; Meningeal; Meninges; Mouse Strains; Multiple Sclerosis; Mus; Nerve; Peptides; Reporter; Research; Role; System; brain cell; complement system; experimental study; gene complementation; in vivo; mouse model; neuroinflammation; neuron development

The role of intracellular and/or cell-autonomous complement in immune cells in the meninges during infection and during neuro-inflammatory disease such as multiple sclerosis is completely unexplored. Thus, this is an entirely new research area which we have just started. We have now generated unique mouse strains with specific deletion of selected complement genes in specific brain cells and are currently assessing these in mouse models of MS. We are targeting specifically the C5 system because we have generated a floxed C5 reporter mouse line. Experiments will also be combined in the future with the in vivo application of C5 targeting peptides, etc.

细胞内和/或细胞自主补体在脑膜中的免疫细胞在感染期间和在神经炎性疾病如多发性硬化期间的作用是完全未探索的。这是一个全新的研究领域，我们刚刚开始。我们现在已经产生了独特的小鼠品系，在特定的脑细胞中特异性缺失选定的补体基因，目前正在MS小鼠模型中评估这些小鼠品系。我们专门针对C5系统，因为我们已经产生了一个floxed C5报告小鼠品系。未来还将结合C5靶向肽的体内应用等进行实验。