TFH-TARGETING GENETIC ADJUVANTS TO PROMOTE DURABLE ANTI-INFLUENZA STEM ANTIBODIES IN OLDER ADULTS.
靶向 TFH 的基因佐剂可促进老年人产生持久的抗流感干抗体。
基本信息
- 批准号:10933286
- 负责人:
- 金额:$ 60万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-30 至 2025-09-29
- 项目状态:未结题
- 来源:
- 关键词:AddressAdenovirus VectorAdenovirusesAdjuvantAntibodiesAntibody ResponseAntigensCD3 AntigensContractorElderlyEngineeringEpitopesGeneticHemagglutininHumanInfluenzaLeadLicensingMacaca mulattaMessenger RNAMethodsMusNIH Vaccine Research CenterSafetySerotypingStructure of germinal center of lymph nodeTestingTransfer AgreementVaccine AdjuvantVaccine ResearchVaccinesValidationadaptive immune responseagedanti-influenzadata exchangefluimmunogenicityimmunoreactivityinfluenza virus vaccinelipid nanoparticleneutralizing antibodysafety testingstemvaccine candidatevaccine developmentvaccine platformvector
项目摘要
The project is focused on progressing BiTar-s3, a vaccine adjuvant agent. The project will develop a vaccine that targets HA stem epitopes shared across many flu-A strains, thereby addressing the difficulty of eliciting heterosubtypic neutralizing antibodies (nAb) against influenza. Specifically, the project’s aims are constructing immunogens fused to the BiTar-s3 adjuvant, to select a lead vaccine candidate; test safety and immunogenicity of the s3-adjuvanted candidate in mice; and test safety and immunogenicity of the s3-adjuvanted and unadjuvanted vaccine candidate in aged rhesus macaques. Methods will include testing expression and immunoreactivity with anti-HA antibodies of targeted candidate immunogens, engineering the selected immunogen into a high-capacity adenovector, testing the ability of s3 to drive anti-HA stem Tfh and antibody responses, testing safety of the s3-adjuvanted and unadjuvanted vaccines in aged rhesus macaques, evaluating adaptive immune responses, and examining the mechanisms of s3 adjuvant activity in germinal centers.
该项目的重点是开发疫苗佐剂BiTar-s3。该项目将开发一种针对许多甲型流感病毒株共有的HA干细胞表位的疫苗,从而解决引发针对流感的异亚型中和抗体(nAb)的困难。具体而言,该项目的目标是构建与BiTar-s3佐剂融合的免疫原,以选择领先的候选疫苗;在小鼠中测试s3佐剂候选疫苗的安全性和免疫原性;并在老年恒河猴中测试s3佐剂和无佐剂候选疫苗的安全性和免疫原性。方法将包括测试靶向候选免疫原的表达和与抗HA抗体的免疫反应性,将选择的免疫原工程化到高容量腺载体中,测试s3驱动抗HA茎Tfh和抗体应答的能力,测试s3佐剂化和无佐剂化疫苗在老年恒河猴中的安全性,评估适应性免疫应答,并检查S3佐剂活性在生发中心的机制。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KENTNER SINGLETON其他文献
KENTNER SINGLETON的其他文献
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{{ truncateString('KENTNER SINGLETON', 18)}}的其他基金
AUGMENTING THE QUALITY AND DURATION OF THE IMMUNE RESPONSE WITH A NOVEL TLR2 AGONIST-ALUMINUM COMBINATION ADJUVANT
使用新型 TLR2 激动剂-铝组合佐剂增强免疫反应的质量和持续时间
- 批准号:
10933287 - 财政年份:2023
- 资助金额:
$ 60万 - 项目类别:
MULTIVALENT QS-18 PROTEIN NANOPARTICLES FOR A BROADLY PROTECTIVE INFLUENZA VIRUS VACCINE
用于广泛保护性流感病毒疫苗的多价 QS-18 蛋白纳米颗粒
- 批准号:
10933284 - 财政年份:2023
- 资助金额:
$ 60万 - 项目类别:
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