Epitope-directed monoclonal antibody production for mosquito immune cells (for malaria)

针对蚊子免疫细胞（针对疟疾）的表位定向单克隆抗体生产

• 批准号: 10933280
• 负责人: YANG YU
• 金额: $ 60万
• 依托单位: LUNA LABS USA, LLC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10933280
• 关键词: Antibodies; Antigens; Cells; Cellular Immunity; Culicidae; Epitopes; Hemocytes; Human; Humoral Immunities; Immune; Immune response; Immunoassay; Malaria; Mediating; Monoclonal Antibodies; Proteins; Research; Surface Plasmon Resonance; Validation; Vector-transmitted infectious disease; biomarker identification; disease transmission; monoclonal antibody production; pathogen

Luna Labs proposes to develop monoclonal antibodies (mAbs) for use in the identification and characterization of mosquito immune cells for immune responses and validation through various immunoassays and surface plasmon resonance (SRP). Since the project focuses on target proteins expressed in mosquito hemocytes that mediate innate cellular and humoral immunity to pathogens, and the antibodies produced will promote the research on human vector-borne diseases transmitted by mosquitoes.

Luna Labs提出开发单克隆抗体（mAb），用于识别和表征蚊子免疫细胞，通过各种免疫测定和表面等离子体共振（SRP）进行免疫应答和验证。由于该项目的重点是蚊子血细胞中表达的介导对病原体的先天性细胞和体液免疫的靶蛋白，所产生的抗体将促进对蚊子传播的人类媒介传播疾病的研究。