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Behavioral and physiological consequences of auditory nerve loss

听神经丧失的行为和生理后果

基本信息

批准号：
10933061
负责人：
Kenneth Stuart Henry
金额：
$ 2.53万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10933061
关键词：
Acoustic Nerve Affect Age Animals Auditory Perception Auditory Threshold Auditory system Behavioral Biological Models Birds Central Nervous System Clinical Cochlea Code Complex Computer Models Data Detection Discrimination Fiber Frequencies Glutamates Goals Hair Cells Health Hearing Hearing Tests Human Impairment Individual Kainic Acid Knowledge Learning Mammals Masks Melopsittacus Methods Midbrain structure Modeling Nerve Fibers Neural Inhibition Neurons Noise Operant Conditioning Pathology Pathway interactions Pattern Perception Performance Periodicals Persons Physiological Play Population Procedures Process Property Public Health Recording of previous events Research Research Project Grants Role Sensorineural Hearing Loss Signal Detection Analysis Signal Transduction Speech Speech Discrimination Speech Perception Stimulus Stream Structure Task Performances Technology Testing Training Work analog auditory pathway auditory processing awake base behavioral impairment behavioral study cell injury cochlear lesion combat experience experimental study extracellular improved innovation insight mouse model nerve damage nerve injury neural neurophysiology response segregation sensory input signal processing sound spiral ganglion therapy development

项目摘要

Permanent loss of auditory-nerve (AN) spiral ganglion neurons is a prevalent cochlear pathology in humans that does not impact clinical audiometric thresholds in quiet. Reduced sensory input to the auditory pathway could potentially degrade speech-perception abilities in affected individuals, but support for this hypothesis is unclear. The goal of the proposed study is to pinpoint aspects of auditory perception impacted by AN damage and characterize the physiological changes underlying perceptual impairment. Many natural signals, including speech, contain complex patterns of amplitude modulation (hereafter, ‘modulation’) that are processed by modulation-tuned neurons in the central nervous system. Modulation tuning emerges in the midbrain due to inhibition, and can play a key processing role in noise by segregating competing sounds into discrete processing streams based on differences in modulation frequency. Building upon prior findings of diminished inhibitory signaling following AN injury, the proposed research will test the hypothesis that AN damage selectively impairs complex-signal perception in noise while sparing audiometric thresholds due to a deficit in neural modulation tuning. Behavioral and neurophysiological studies will be conducted in the budgerigar, an avian model species capable of mimicking speech. Strengths of the budgerigar model system include human- like behavioral performance on complex-listening tasks and midbrain processing mechanisms shared with mammals, including many neurons with prominent modulation tuning. Furthermore, selective AN damage can be induced in budgerigars using the glutamate analog kainic acid. New behavioral and neurophysiological experiments will investigate the impact of kainic-acid induced AN damage on auditory processing. Aim 1 will use operant-conditioning procedures in behaviorally trained animals to identify aspects of auditory perception impacted by AN damage. Preliminary data support our hypothesis that AN damage has no effect on audiometric thresholds in quiet yet can impair performance of tasks that rely on modulation tuning. Aim 2 will use extracellular midbrain recordings in awake animals to quantify effects of AN damage on neural inhibition, modulation tuning, and encoding of complex speech-like signals in competing noise. We hypothesize that AN damage will reduce the strength of modulation tuning due to diminished inhibition, and consequently degrade encoding of synthetic vowels and consonants in noise. Aim 3 will use single-fiber AN recordings to test the hypothesis that AN response properties in budgerigars are similar to those found in mammals and other avian species, with higher-threshold fibers lost following kainic-acid exposure. New physiological results will be used to refine a computational model of subcortical auditory processing. Completion of these aims will provide crucial insight into the impact of AN damage on auditory perception of simple and complex sounds and the changes in neural processing associated with perceptual impairment. Understanding these effects is an essential step toward developing an informed public health strategy to treat this common cochlear pathology.

听觉神经（AN）螺旋神经节神经元的永久性损失是一种普遍的人类耳蜗病理

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Effects of selective auditory-nerve damage on the behavioral audiogram and temporal integration in the budgerigar.

选择性听觉神经损伤对虎皮鹦鹉行为听力图和时间整合的影响。

DOI：
10.1016/j.heares.2019.01.019
发表时间：
2019
期刊：
Hearing research
影响因子：
2.8
作者：
Wong,StephanieJ;Abrams,KristinaS;Amburgey,KassidyN;Wang,Yingxuan;Henry,KennethS
通讯作者：
Henry,KennethS

Normal behavioral discrimination of envelope statistics in budgerigars with kainate-induced cochlear synaptopathy.

具有红藻氨酸诱导的耳蜗突触病的虎皮鹦鹉包膜统计的正常行为辨别。