NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED) FOR THE CENTRALIZED OMICS RESOURCE (CORE) - TASK AREAS 2, 3, AND 4

用于集中组学资源（核心）的精准医学 NHLBI 跨组学 (TOPMED) - 任务领域 2、3 和 4

• 批准号: 10974191
• 负责人: ASHLIN BOLTON
• 金额: $ 327.14万
• 依托单位: BROAD INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-28 至 2024-09-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10974191
• 关键词: NHLBI; TRANS; OMICS; PRECISION; MEDICINE

NHLBI's Trans-Omics for Precision Medicine (TOPMed) program started in 2014 as the flagship program supporting the development of precision medicine for heart, lung, blood diseases and sleep disorders. The main goal is to generate a large volume of genomics data that have sufficient statistical power for scientific discovery. The data are generated and processed first in TOPMed before being uploaded to external databases, database of Genotypes and Phenotypes (dbGaP) and BioData Catalyst (BDC) for researchers to access. In 2016, under TOPMed program, NHLBI funded nine (9) Centralized Omics Resource (CORE) centers that have generated approximately 200,000 whole genome sequencing and multi-omics data. As TOPMed enters its next phase TOPMed2.0 focusing on functional genomics and disease mechanism, the CORE needs to be upgraded to CORE 2.0 generating more functional genomics data, including omics data at single-cell resolution. CORE 2.0 needs to generate a large volume of functional genomics data and is in need of contractors that can provide a high capability of generating omics data.

NHLBI 的精准医学跨组学 (TOPMed) 项目于 2014 年启动，是支持心脏、肺、血液疾病和睡眠障碍精准医学开发的旗舰项目。主要目标是生成大量基因组数据，这些数据具有足够的统计能力用于科学发现。数据首先在 TOPMed 中生成和处理，然后上传到外部数据库、基因型和表型数据库 (dbGaP) 和 BioData Catalyst (BDC) 供研究人员访问。 2016 年，根据 TOPMed 计划，NHLBI 资助了九 (9) 个集中组学资源 (CORE) 中心，这些中心已生成约 200,000 个全基因组测序和多组学数据。随着 TOPMed 进入下一阶段 TOPMed2.0，重点关注功能基因组学和疾病机制，CORE 需要升级到 CORE 2.0，生成更多功能基因组学数据，包括单细胞分辨率的组学数据。 CORE 2.0需要生成大量的功能基因组数据，需要能够提供高组学数据生成能力的承包商。