JACKSON HEART STUDY (JHS)- COMMUNITY ENGAGEMENT CENTER (CEC) - TASK AREA C CORE STUDIES AND CLOSEOUT ACTIVITIES

杰克逊心脏研究 (JHS) - 社区参与中心 (CEC) - 任务领域 C 核心研究和收尾活动

• 批准号: 10972983
• 负责人: VICTOR SUTTON
• 金额: $ 132.92万
• 依托单位: MISSISSIPPI STATE DEPARTMENT OF HEALTH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-13 至 2025-08-12
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10972983
• 关键词: JACKSON; HEART; STUDY; JHS; COMMUNITY

The Jackson Heart Study (JHS) (https://www.jacksonheartstudy.org/) initiated in 1998 is a longitudinal investigation of genetic and environmental risk factors associated with the disproportionate burden of cardiovascular disease in African Americans. In addition, the JHS conducts community education and outreach activities to promote healthy lifestyles and reduce disease risk burden, undergraduate and graduate level research training programs, and high school science and math enrichment programs to prepare and encourage underrepresented minority students to pursue biomedical careers. The JHS is funded by the National Heart, Lung and Blood Institute (NHLBI) and the National Institute on Minority Health and Health Disparities (NIMHD). The JHS represents an expansion of the Jackson Field Center of the Atherosclerosis Risk in Communities (ARIC) study (http://www2.cscc.unc.edu/aric/) to broaden data collection in an African American population and to increase access to and participation of African American populations and scientists in biomedical research and professions. The JHS recruited 5306 African American residents living in the Jackson, Mississippi, metropolitan area of Hinds, Madison, and Rankin Counties. Participants were enrolled from 4 recruitment pools: random, 17%; volunteer, 30%; currently enrolled in the ARIC Study, 31% and secondary family members, 22%. Recruitment was limited to non-institutionalized adult African American men and women, 35-84 years old, except in a nested family cohort where those 21 to 34 years of age were also eligible. The final cohort of participants enrolled during the baseline exam included 6.6% of all African American men and women residents of the Jackson Mississippi Metropolitan Statistical Area aged 35-84 (N=76,426, US Census 2000). Among these participants, approximately 3400 gave consent that allows genetic research. JHS participants received three back-to-back clinical examinations (Exam 1, 2000-2004; Exam 2, 2005-2008; and Exam 3, 2009-2013) that have generated extensive longitudinal data on traditional and putative cardiovascular disease risk factors and measures of subclinical cardiovascular disease from echocardiography, cardiac magnetic resonance imaging and computed tomography scans. Biological samples (i.e., blood and urine) have been assayed for putative biochemical risk factors and stored for future research. DNA has been extracted and lymphocytes have been cryopreserved for studies of candidate genes, genome-wide scanning, expression, and other –omics investigations. In addition, JHS participants are contacted annually by telephone to update personal and health information including vital status, interim medical events, hospitalizations, functional status and sociocultural information. Ongoing cohort surveillance for cardiovascular events (i.e., coronary heart disease and related procedures, heart failure, and stroke) and deaths also involves data linkage with hospital discharge lists of JHS catchment area hospitals and the National Death Index (NDI). Medical records of cardiovascular disease related hospitalizations and death certificates are abstracted and used for adjudication of cardiovascular events and related deaths. The current JHS contracts (2018-2024) will include a clinical examination (Exam 4, 2/2020-11/2022) and investigation of the link between cardiovascular health and brain health.

杰克逊心脏研究（JHS） （https://www.jacksonheartstudy.org/）于1998年启动，是一项与非裔美国人心血管疾病不成比例负担相关的遗传和环境风险因素的纵向调查。此外，JHS还开展社区教育和外展活动，以促进健康的生活方式，减少疾病风险负担，开展本科生和研究生水平的研究培训计划，以及高中科学和数学丰富计划，以准备和鼓励代表性不足的少数民族学生从事生物医学事业。JHS由国家心脏、肺和血液研究所（NHLBI）和国家少数民族健康和健康差异研究所（NIMHD）资助。JHS是Jackson Field社区动脉粥样硬化风险研究中心（ARIC）研究（http://www2.cscc.unc.edu/aric/）的扩展，旨在扩大非洲裔美国人的数据收集，并增加非洲裔美国人和科学家在生物医学研究和专业领域的参与。JHS招募了5306名居住在密西西比州杰克逊、海因兹、麦迪逊和兰金县大都市区的非裔美国人。参与者从4个招募池中入组：随机，17%；志愿者,30%;目前参加ARIC研究的占31%，第二家庭成员占22%。招募仅限于35-84岁的非机构成年非洲裔美国男性和女性，除了在一个嵌套的家庭队列中，21 - 34岁的人也符合条件。在基线测试期间登记的最后一组参与者包括6.6%的杰克逊密西西比大都会统计区35-84岁的非裔美国男性和女性居民（N=76,426, 2000年美国人口普查）。在这些参与者中，大约有3400人同意进行基因研究。JHS参与者接受了三次连续的临床检查（检查1,2000-2004年；检查2,2005-2008年；检查3,2009-2013年），这些检查产生了关于传统和假定的心血管疾病危险因素以及通过超声心动图、心脏磁共振成像和计算机断层扫描测量亚临床心血管疾病的大量纵向数据。生物样本（即血液和尿液）已被分析推定的生化危险因素，并保存以供将来研究。DNA已被提取，淋巴细胞已被冷冻保存，用于候选基因的研究，全基因组扫描，表达和其他组学研究。此外，每年通过电话联系JHS参与者，以更新个人和健康信息，包括生命状况、临时医疗事件、住院情况、功能状况和社会文化信息。正在进行的心血管事件（即冠心病和相关手术、心力衰竭和中风）和死亡队列监测还涉及与JHS集水区医院出院名单和国家死亡指数（NDI）的数据联系。提取心血管疾病相关住院病历和死亡证明，用于判定心血管事件和相关死亡。目前的JHS合同（2018-2024）将包括临床检查（2020年2月- 2022年11月）和心血管健康与大脑健康之间联系的调查。